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Toxicological information

Acute Toxicity: oral

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Administrative data

Endpoint:
acute toxicity: oral
Adequacy of study:
disregarded due to major methodological deficiencies
Reliability:
3 (not reliable)
Rationale for reliability incl. deficiencies:
other: ZrCl4 is administered via the drinking water and under this condition, ZrCl4 is directly decomposed into ZrOCl2 and HCl. So during the experiment, the degradation products of ZrCl4 are ingested but not ZrCl4 itself.
Cross-reference
Reason / purpose:
reference to other study

Data source

Reference
Reference Type:
publication
Title:
Toxicité et pharmacocinétique de l'oxychlorure de zirconium chez la souris et chez le rat
Author:
Delongeas J.L, Burnel D, Netter P, Grignon M, Mur J.M, Royer R.-J, Grignon G
Year:
1983
Bibliographic source:
J.Pharmacol., 1983, 14, 4, 437-447

Materials and methods

Principles of method if other than guideline:
Single oral dose administration
GLP compliance:
no
Test type:
other: Single oral dose administration
Limit test:
no

Test material

Reference
Name:
Unnamed
Type:
Constituent
Details on test material:
Name of test material: Zirconium Chloride from Prolabo

Test animals

Species:
mouse
Strain:
Swiss
Sex:
female
Details on test animals and environmental conditions:
Weight at study initiation: 20g +/-1 g

Administration / exposure

Route of administration:
oral: unspecified
Vehicle:
water
Doses:
No information but doses follow a geometric progression of 1.1.
No. of animals per sex per dose:
24 total animals were used.
Control animals:
not specified

Results and discussion

Effect levels
Sex:
female
Dose descriptor:
LD50
Effect level:
ca. 438 mg/kg bw
Based on:
test mat.
95% CL:
> 412 - < 489
Remarks on result:
other: On the basis of the Bliss method

Any other information on results incl. tables

The rats died during the first 24 hours showed convulsions. The rats died after the first day and before the last day of observation showed inappetance, weight loss and prostration.

At certain concentrations, cerebral and pulmonary disorders are observed.

Post-mortem examination showed often intestinal necrosis and sometimes pulmonary necrosis.

Applicant's summary and conclusion

Conclusions:
Under the conditon of this study, the LD50 of ZrCl4 is 438 mg/kg bw. But ZrCl4 is administered via the drinking water and ZrCl4 is decomposed into ZrOCl2 and HCl. So during the experiment, the degradation products of ZrCl4 are ingested but not ZrCl4. This study is not relevant for ZrCl4.