Registration Dossier
Registration Dossier
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EC number: 604-138-8 | CAS number: 139481-59-7
Additional information on environmental fate and behaviour
Administrative data
- Endpoint:
- additional information on environmental fate and behaviour
- Type of information:
- calculation (if not (Q)SAR)
- Remarks:
- Migrated phrase: estimated by calculation
- Adequacy of study:
- other information
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: see 'Remark'
- Remarks:
- A reliable secondary source, summarising Candesartan properties, was used. However the primary sources were not revisited in order to verify their contents; for this reason reliability score 2 was used; it covers the most updated literature on the substance.
Cross-reference
- Reason / purpose for cross-reference:
- reference to same study
Data source
Reference
- Reference Type:
- secondary source
- Title:
- Candesartan - DB00796 (APRD00420)
- Bibliographic source:
- DrugBank
Materials and methods
- Principles of method if other than guideline:
- no data
- GLP compliance:
- not specified
- Type of study / information:
- Biodegradation
Test material
- Reference substance name:
- 2-ethoxy-1-{[2'-(1H-1,2,3,4-tetrazol-5-yl)-[1,1'-biphenyl]-4-yl]methyl}-1H-1,3-benzodiazole-7-carboxylic acid
- EC Number:
- 604-138-8
- Cas Number:
- 139481-59-7
- Molecular formula:
- C24H20N6O3
- IUPAC Name:
- 2-ethoxy-1-{[2'-(1H-1,2,3,4-tetrazol-5-yl)-[1,1'-biphenyl]-4-yl]methyl}-1H-1,3-benzodiazole-7-carboxylic acid
- Test material form:
- not specified
- Details on test material:
- no data
Constituent 1
Results and discussion
Any other information on results incl. tables
Not ready biodegradable
Applicant's summary and conclusion
- Conclusions:
- ADMET features of Candesartan were predicted; the substance was judged as not ready biodegradable (probability: 0.9972).
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