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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

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Environmental fate & pathways

Bioaccumulation: aquatic / sediment

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Description of key information

Calculation with BCFBAFWIN v3.00 (EPIWIN software by US-EPA), Bioconcentration Factor (BCF): 14.2 (regression-based estimate) 

Key value for chemical safety assessment

BCF (aquatic species):
14.2 L/kg ww

Additional information

The prediction for the bioconcentration factor (BCF) of the test substance was determined by the computer program BCFBAFWIN v3.00 (EPIWIN software) by US-EPA (Chemservice S.A., 2011). Furthermore the whole body primary biotransformation rate estimation for fish was calculated with the notation that the bio half-life normalized to 10 g fish at 15 °C. It is possible to predict the apparent metabolism half-life in fish for three different trophic levels (lower, mid and upper). Using the regression-based estimate (traditional method) a Bioconcentration Factor (BCF) of 14.2 L/kg wet-wt was calculated. Using the Arnot-Gobas method, which is based on mechanistic first principles, an aquatic BCF of 19.9 L/kg wet-wt is the result. The experimentally determined logPow of 2.25 was taken into account for these predictions (White and Mullee, 2001, shake flask method, at 30 °C). The whole body primary biotransformation rate estimate for fish results in a half-life of 0.24 days, whereby the bio half-life is normalized to 10 g fish at 15 °C. The rate constant (kM) for 10 g fish is 2.91/day. This is taken into account to predict the apparent metabolism half-life in fish of the test substance. With the Arnot-Gobas method it is possible to differentiate between three trophic levels. For the lower trophic level the BCF results in 10.54 L/kg wet-wt, for a mid trophic level the result is 11.65 L/kg wet-wt and for the higher trophic level 15.62 L/kg wet-wt. No correction factors were applied.

No GLP criteria are applicable for the usage of this tool, but due to the fact that it is a scientifically accepted calculation method the estimations performed are reliable with restrictions and can be used for the chemical safety assessment.