Benzeneacetic acid, 2-(chloromethyl)-.alpha.-(methoxymethylene)-, methyl ester

Acute Toxicity: dermal

Administrative data

Endpoint:

acute toxicity: dermal

Type of information:

experimental study

Adequacy of study:

supporting study

Reliability:

2 (reliable with restrictions)

Rationale for reliability incl. deficiencies:

study well documented, meets generally accepted scientific principles, acceptable for assessment

Data source

Reference

Reference Type:

study report

Title:

Unnamed

Year:

1998

Report date:

1998

Materials and methods

Principles of method if other than guideline:

A group of 2 male and 2 female rats received a single dermal application of 2000 mg/kg test substance. The animals were assessed daily for 7 days for signs of toxicity, skin irritation and body weight. At the end of the study the animals were killed and subjected to a macroscopic examination post mortem.

GLP compliance:

yes

Test type:

standard acute method

Limit test:

yes

Test material

Test material information

Constituent 1

Reference substance name:

-

EC Number:

473-070-7

EC Name:

-

Cas Number:

117428-95-2

Molecular formula:

C12 H13 Cl O3

IUPAC Name:

methyl (2E)-2-[2-(chloromethyl)phenyl]-3-methoxyprop-2-enoate

Details on test material:

-Purity: not reported

Specific details on test material used for the study:

Test substance: ZA1963 Stage 5 EW
Purity: Not reported

Test animals

Species:

rat

Strain:

not specified

Sex:

male/female

Administration / exposure

Type of coverage:

not specified

Vehicle:

unchanged (no vehicle)

Duration of exposure:

7 days

Doses:

2000 mg/kg

No. of animals per sex per dose:

2

Control animals:

no

Results and discussion

Effect levels

Key result

Sex:

male/female

Dose descriptor:

LD50

Effect level:

> 2 000 mg/kg bw

Based on:

test mat.

Mortality:

None of the animals died

Clinical signs:

other:

Body weight:

other body weight observations

Remarks:

Both the males gained weight during the study. The bodyweight of both females was essentially the same at the start and end of the study.

Gross pathology:

There were no macroscopic abnormalities

Other findings:

Signs of slight skin irritation (including erythema, edema and desquamation) were seen in two males and one female.

All signs of skin irritation had fully regressed by day 7.

Applicant's summary and conclusion

Interpretation of results:

GHS criteria not met

Conclusions:

LD50 (Rat) > 2000 mg/kg

Executive summary:

A group of 2 male and 2 female rats received a single dermal application of 2000 mg/kg test substance. The animals were assessed daily for 7 days for signs of toxicity, skin irritation and body weight. At the end of the study the animals were killed and subjected to a macroscopic examination post mortem.

None of the animals died and there were no significant signs of systemic toxicity. Both the males gained weight during the study. The bodyweight of both females was essentially the same at the start and end of the study. Signs of slight skin irritation (including erythema, edema and desquamation) were seen in two males and one female. All signs of skin irritation had fully regressed by day 7. There were no macroscopic abnormalities. The acute dermal median lethal dose was in excess of 2000 mg/kg to male and female rats.