Registration Dossier
Registration Dossier
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EC number: 205-533-4 | CAS number: 142-30-3
Eye irritation
Administrative data
- Endpoint:
- eye irritation: in vivo
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Non-GLP non-guideline study, available as unpublished report, limitations in design and/or reporting (no data on 48 and 72 hours time point) but otherwise adequate for assessment
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 973
- Report date:
- 1973
Materials and methods
Test guideline
- Qualifier:
- no guideline followed
- Principles of method if other than guideline:
- Two white Vienna rabbits were used and 50 mg of the test substance were applied to the conjunctival sac of the eye. Talcum powder was used as a control. The animals were observed for 8 days and findings were recorded.
- GLP compliance:
- no
Test material
- Reference substance name:
- 2,5-dimethylhexyne-2,5-diol
- EC Number:
- 205-533-4
- EC Name:
- 2,5-dimethylhexyne-2,5-diol
- Cas Number:
- 142-30-3
- Molecular formula:
- C8H14O2
- IUPAC Name:
- 2,5-dimethylhex-3-yne-2,5-diol
- Details on test material:
- - Name of test material (as cited in study report): Dimethylhexindiol
Constituent 1
Test animals / tissue source
- Species:
- rabbit
- Strain:
- not specified
Test system
- Vehicle:
- unchanged (no vehicle)
- Controls:
- other: talcum powder
- Amount / concentration applied:
- 1 x 50 mm3 (comparable to 50 mg)
- Observation period (in vivo):
- 8 days
- Details on study design:
- The test substance was not washed out.
Results and discussion
In vivo
Resultsopen allclose all
- Irritation parameter:
- cornea opacity score
- Basis:
- mean
- Time point:
- other: 24 hours
- Score:
- 1
- Max. score:
- 3
- Reversibility:
- fully reversible within: 8 days
- Irritation parameter:
- conjunctivae score
- Basis:
- mean
- Time point:
- other: 24 hours
- Score:
- 2
- Max. score:
- 3
- Reversibility:
- fully reversible within: 8 days
- Irritation parameter:
- chemosis score
- Basis:
- mean
- Time point:
- other: 24 hours
- Score:
- 1
- Max. score:
- 3
- Reversibility:
- fully reversible within: 8 days
- Irritant / corrosive response data:
- - Slight redness, marked oedema, slight corneal opacity, and a fatty layer on the eye were observed in animals exposed to the test substance 1 hour after exposure.
- Marked redness, slight oedema and slight corneal opacity were observed in animals exposed to the test substance 24 hours after exposure.
- No effects observed in animals exposed to the test substance 8 days after exposure.
- Slight redness was observed in animals exposed to talcum powder 1 hour and 24 hours after exposure.
Applicant's summary and conclusion
- Interpretation of results:
- irritating
- Remarks:
- Migrated information
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