Registration Dossier
Registration Dossier
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EC number: 203-016-8 | CAS number: 102-24-9
Endpoint summary
Administrative data
Key value for chemical safety assessment
Additional information
Justification for classification or non-classification
Triboron trimethyl hexaoxide is expected to hydrolyse in contact with water to form methanol (CAS 67-56-1) and boric acid (CAS 10043-35-3) (Steinberg and Hunter, 1957). For both hydrolysis products relevant genetic toxicity data was gathered from the ECHA dissemination dossier (d.d. 2014 -04 -25) and tabulated below. The classification of the parent substance is based on the worst case classification of both hydrolysis products.
Genetic toxicity data for methanol:
Study |
Species |
Type of method |
Result |
Gene mutation (Ames test) |
S. typhimurium and E.coli |
In vitro |
Negative |
Gene mutation |
Chinese hamster lung fibroblasts (V79) |
In vitro |
Negative |
Chromosome aberration |
Chinese hamster lung fibroblasts (V79) |
In vitro |
Negative |
Chromosome aberration |
Mouse |
In vivo |
Negative |
Genetic toxicity data for boric acid:
Study |
Species |
Type of method |
Result |
Gene mutation (Ames test) |
S. typhimurium |
In vitro |
Negative |
Gene mutation |
Mouse lymphoma L5178Y cells |
In vitro |
Negative |
DNA damage and/or repair |
Chinese hamster Ovary (CHO) |
In vitro |
Negative |
Chromosome aberration |
Mouse |
In vivo |
Negative |
In accordance with Regulation EC/1272/2008 and Directive 67/548/EEC, methanol and boric acid are not considered to be classified for genetic toxicity.
Triboron trimethyl hexaoxide does not need to be classified for genetic toxicity in accordance with Regulation EC/1272/2008 and Directive 67/548/EEC.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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