Triboron trimethyl hexaoxide

Acute Toxicity: inhalation

Administrative data

Endpoint:

acute toxicity: inhalation

Type of information:

experimental study

Adequacy of study:

key study

Reliability:

2 (reliable with restrictions)

Rationale for reliability incl. deficiencies:

other: Non-GLP study, no guideline followed; not single exposure but 9

Data source

Reference

Reference Type:

publication

Title:

The subacute inhalation toxicity of 109 industrial chemicals

Author:

Gage

Year:

1970

Bibliographic source:

Brlt . J. industr . Med., 1970, 27, 1-1 8

Materials and methods

Test guideline

Qualifier:

no guideline followed

Principles of method if other than guideline:

Rats were exposed to the test substance for 6h/d nine times; in this study the effect of several chemicals following inhalation was tested

GLP compliance:

no

Test type:

other: repeated inhalation

Test material

Test material information

Constituent 1

Reference substance name:

Triboron trimethyl hexaoxide

EC Number:

203-016-8

EC Name:

Triboron trimethyl hexaoxide

Cas Number:

102-24-9

Molecular formula:

C3H9B3O6

IUPAC Name:

trimethoxy-1,3,5,2,4,6-trioxatriborinane

Details on test material:

The samples submitted by ICI Divisions were prepared in either the Research Department or an experimental plant, or were taken from full-scale production

Test animals

Species:

rat

Strain:

other: Alderley Park specific-pathogen-free rats

Sex:

male/female

Details on test animals or test system and environmental conditions:

No details in environmental condictions given

Administration / exposure

Route of administration:

inhalation: vapour

Type of inhalation exposure:

whole body

Details on inhalation exposure:

Atmospheres were continuously generated and passed through the exposure chamber. The air used fot the atmospheres was filtered, dried to a
relative humidity of less than 10%, and supplied at a line pressure of 1 atm. A nearly saturated vapour obtained by passing air through a liquid contained in a bubbler with a sintered glass air-distributor disc . The volume of the liquid was usually 10-20 ml and, if the size of the sample available permitted, it was replaced daily . Unless otherwise stated, the bubbler was maintained in a water-bath at room temperature, about 20°C.
The nearly saturated concentration was estimated by weighing the sample before and after the day's run, and relating the weight loss to the volume of air passing . This concentration, expressed in milligrammes per litre, was converted to parts per million on the assumption that the sample was pure .

Analytical verification of test atmosphere concentrations:

not specified

Duration of exposure:

6 h

Remarks on duration:

9 exposures

Concentrations:

Saturated atmosphere

No. of animals per sex per dose:

3 M/ 4F

Details on study design:

Rats were weighed each morning, and their conditions and behaviour were recorded throughout the exposure period . Urine was collected overnight after the last exposure day for biochemical tests . The animals were left overnight with food and drink . On the following day the rats were anaesthetized with halothane and partially exsanguinated by heart puncture for haematological tests . After a gross examination of the organs, the lungs were inflated with formol-saline and immersed in the same fixative . The following organs were also taken for microscopical examination after fixation
in formol-corrosive : lungs, liver, kidneys, spleen, and adrenals ; and occasionally heart, jejunum, ileum, and thymus.

Results and discussion

Effect levels

Sex:

male/female

Dose descriptor:

LC50

Effect level:

> 3 mg/L air

Mortality:

no mortalities described

Clinical signs:

other: slight lethargy

Body weight:

no data

Gross pathology:

Organs normal