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EC number: 209-132-5 | CAS number: 556-61-6
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data

Skin irritation / corrosion
Administrative data
- Endpoint:
- skin irritation: in vivo
- Type of information:
- experimental study
- Adequacy of study:
- supporting study
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- other: GLP Guideline study (OECD 404)
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 985
- Report date:
- 1985
Materials and methods
Test guidelineopen allclose all
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 404 (Acute Dermal Irritation / Corrosion)
- Deviations:
- no
- Qualifier:
- according to guideline
- Guideline:
- other: EPA - Pesticide assessment guidelines
- Deviations:
- not specified
- GLP compliance:
- yes
Test material
- Reference substance name:
- Methyl isothiocyanate
- EC Number:
- 209-132-5
- EC Name:
- Methyl isothiocyanate
- Cas Number:
- 556-61-6
- Molecular formula:
- C2H3NS
- IUPAC Name:
- isothiocyanatomethane
- Details on test material:
- Test article name : METHYLSENFOEL (MITC)
Source: DEGUSSA AG
Purity: technical
Constituent 1
Test animals
- Species:
- rabbit
- Strain:
- New Zealand White
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
- Source: Kleintierfarm madoerin AG (CH 4414 Fuellinsdorf, Switzerland)
- Age at study initiation: 15-16 week-old
- Weight at study initiation: 2.4/2.6 kg
- Housing: individually in stainless steel cages equipped with an automatic cleaning and drinking system.
- Diet (e.g. ad libitum): pelleted standard kliba 341, ad libitum
- Water (e.g. ad libitum):Tap water, ad libitum
- Acclimation period: 4 days
ENVIRONMENTAL CONDITIONS
- Temperature (°C): 22+/-2
- Humidity (%): 55+/-10%
- Air changes (per hr): 10-15
- Photoperiod (hrs dark / hrs light):12/12 (8h music/light period)
Test system
- Type of coverage:
- occlusive
- Preparation of test site:
- shaved
- Vehicle:
- unchanged (no vehicle)
- Controls:
- no
- Amount / concentration applied:
- TEST MATERIAL
- Amount(s) applied (volume or weight with unit): 0.5 ml
- Concentration (if solution): no data
no VEHICLE - Duration of treatment / exposure:
- 4 hours
- Observation period:
- 4 hours
- Number of animals:
- 3 = 1 male + 2 females
- Details on study design:
- TEST SITE
- Area of exposure: the dorsal
- % coverage: patch = 3x3cm
- Type of wrap if used: Skin was recovered with a patch of surgical gauze. The gauze was covered with aluminium foil and then covered with an occlusive dressing. The dressing was wrapped around the abdomen and anchored with an elastic bandage.
REMOVAL OF TEST SUBSTANCE :
Just after the animals death (approximately 1 hour after treatment), the dressing was removed.
SCORING SYSTEM: idem in guideline of OECD 404
Results and discussion
In vivo
Results
- Remarks on result:
- other: All animals died within the 4-hour treatment phase, therefore no irritation index could be determined
- Irritant / corrosive response data:
- All animals died within the 4-hour treatment phase, therefore no irritation index could be determined. The index given below was determined just after removing the occlusive bandage, when the animals were already dead. After 1 hour: for each animal, erythema score = 4 and edema score = 2. After 4 hours: all animals died.
- Other effects:
- Toxic symptoms/mortality: Between one and four hours after application start all animals showed sedation, crying, spasms, dyspnea and curved body position.
Applicant's summary and conclusion
- Interpretation of results:
- other: unconclusive
- Conclusions:
- All animals died within the 4 -hour treatment phase, therefore no irritation index could be determined.
- Executive summary:
The purpose of this primary study skin irritation study was to assess possible irritation potential when single doses of MITC are placed on the skin on rabbits. All animals died within the 4 -hour treatment phase, therefore no irritation index could be determined.
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