Registration Dossier
Registration Dossier
Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.
The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 209-132-5 | CAS number: 556-61-6
Acute Toxicity: other routes
Administrative data
- Endpoint:
- acute toxicity: other routes
- Type of information:
- experimental study
- Adequacy of study:
- other information
- Reliability:
- 4 (not assignable)
- Rationale for reliability incl. deficiencies:
- other: Secondary literature
Data source
Reference
- Reference Type:
- publication
- Title:
- Summary of toxicity data on methyl isothiocyanate (MITC)
- Author:
- Anonymous
- Year:
- 1 990
- Bibliographic source:
- Nippon Noyaku Gakkai (J. Pesticide Sci.), 15(2), 297-304.
Materials and methods
- Principles of method if other than guideline:
- no data
- GLP compliance:
- not specified
Test material
- Reference substance name:
- Methyl isothiocyanate
- EC Number:
- 209-132-5
- EC Name:
- Methyl isothiocyanate
- Cas Number:
- 556-61-6
- Molecular formula:
- C2H3NS
- IUPAC Name:
- isothiocyanatomethane
- Details on test material:
- no data
Constituent 1
Test animals
- Species:
- other: rat and mouse
- Strain:
- not specified
- Sex:
- male/female
- Details on test animals or test system and environmental conditions:
- no data
Administration / exposure
- Route of administration:
- subcutaneous
- Vehicle:
- not specified
- Details on exposure:
- no
- Doses:
- no data
- No. of animals per sex per dose:
- no data
- Control animals:
- not specified
- Details on study design:
- no
- Statistics:
- no data
Results and discussion
Effect levelsopen allclose all
- Sex:
- male
- Dose descriptor:
- LC50
- Effect level:
- 60 mg/kg bw
- Remarks on result:
- other: RATS
- Sex:
- female
- Dose descriptor:
- LC50
- Effect level:
- 59 mg/kg bw
- Remarks on result:
- other: RATS
- Sex:
- male
- Dose descriptor:
- LC50
- Effect level:
- 75 mg/kg bw
- Remarks on result:
- other: MICE
- Sex:
- female
- Dose descriptor:
- LC50
- Effect level:
- 89 mg/kg bw
- Remarks on result:
- other: MICE
- Mortality:
- LD50 were determined.
- Clinical signs:
- no data
- Body weight:
- no data
- Gross pathology:
- no data
- Other findings:
- no data
Applicant's summary and conclusion
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
