Tetrahydro-1,3-dimethyl-1H-pyrimidin-2-one

Acute Toxicity: other routes

Administrative data

Endpoint:

acute toxicity: other routes

Type of information:

experimental study

Adequacy of study:

other information

Reliability:

4 (not assignable)

Rationale for reliability incl. deficiencies:

other: Documentation insufficient for assessment

Data source

Reference

Reference 1

Reference Type:

publication

Title:

Dipole Moments and Pharmacological Activity of Cyclic Ureas, Cyclic Thioureas, and the N,N'-Dimethylated Compounds

Author:

Lien, E.J. & Kumler, W.D.

Year:

1968

Bibliographic source:

J. Med. Chem. 11: 214-219

Reference 2

Reference Type:

publication

Title:

Structural Requirements for CNS Activities and Toxicities of Cyclic Ureas and Thioureas

Author:

Lien et al.

Year:

1982

Bibliographic source:

J. Taiwan Pharm. Assoc. 34(1), 46-52

Reference 3

Reference Type:

publication

Title:

No information

Author:

Miller, L.C. & Tainter, M.L.

Year:

1944

Bibliographic source:

Proc. Soc. Exptl. Biol. Med. 57, 261

Materials and methods

GLP compliance:

no

Test material

Test material information

Constituent 1

Reference substance name:

Tetrahydro-1,3-dimethyl-1H-pyrimidin-2-one

EC Number:

230-625-6

EC Name:

Tetrahydro-1,3-dimethyl-1H-pyrimidin-2-one

Cas Number:

7226-23-5

Molecular formula:

C6H12N2O

IUPAC Name:

tetrahydro-1,3-dimethyl-1H-pyrimidin-2-one

Test animals

Species:

mouse

Administration / exposure

Route of administration:

intraperitoneal

Vehicle:

other: 0.2% water solution was used for dosage <= 100 mg/kg; 2% solution was used for dosage of 300 and 1000 mg/kg. For dosage > 1000 mg/kg, higher concentration and only two mice were used (limited amount of test substance)

Results and discussion

Effect levels

Dose descriptor:

LD50

Effect level:

1 300 mg/kg bw

Remarks on result:

other: LD50 was obtained by the graphic calculation of Miller and Tainter