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EC number: 230-625-6 | CAS number: 7226-23-5
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data

Endpoint summary
Administrative data
Link to relevant study record(s)
Description of key information
There are no specific experimental data available concerning toxicokinetics, metabolism and distribution. Based on the physicochemical properties of the substance and available ecotoxicological and toxicological information it is concluded that the substance is systemically bioavailable after oral administration. In contrast, bioavailability via the dermal route is estimated to be very low. Due to the relatively low vapour pressure of the test substance (0.02 hPa at 25°C), the volatility of the substance is rather low and inhalation exposure to vapors is hence considered to be low. The substance has a low potential for bioaccumulation (Log Pow <3).
Key value for chemical safety assessment
- Bioaccumulation potential:
- low bioaccumulation potential
Additional information
Assessment of the Toxicokinetic Behaviour
Since no toxicokinetic studies are available for N,N'-DIMETHYLPROPYLENE UREA, the following assessment is based on the available physicochemical properties and results from other toxicological studies:
N,N'-DIMETHYLPROPYLENE UREA is a liquid, organic, colourless substance with a small molecular weight of 128.18 g/mol, indicative for a favourable absorbance of the test item.
The test item is miscible with water at room temperature (T = 23°C) and at T = 20.0°C ± 0.5°C in any ratio. Due to this high water solubility, it is predicted that the test item is readily dissolved into the gastrointestinal fluids.
Due to the relatively low calculated vapour pressure of the test substance (0.02 hPa at 20°C), the volatility of the substance is rather low and inhalation exposure to vapors is hence considered to be low.
The partition coefficient of the test substance (Log Pow) is 0.05 at 25°C at pH 7. Based on this rather low partition coefficient the test substance is unlikely to bioaccumulate with the repeated intermittent exposure patterns normally encountered. However, this moderate log Pow value indicates that the substance might be favourable for passive diffusion. In line with this, in an acute oral toxicity study, 4/5 males and females and 1/5 females died after administration of 2000 and 1470 mg/kg bw, respectively, whereas animals receiving 681 mg/kg did not show any signs of mortality (-> LD50 = 1770 mg/kg). Furthermore, animals receiving high and intermediate doses showed clinical signs and symptoms, inlcuding dyspnea, apathy, staggering, twitching, piloerection, cyanosis and a poor general state. These observations are in line with the moderate log Pow value, showing that the substance is systemically bioavailable when administered orally.
In contrast, bioavailability via the dermal route is less likely since the LD50 was estimated to be > 2000 mg/kg. In line with this, a low partition coefficient below 1 predicts low dermal absorbtion. Furthermore, the substance is neither irritating (BASF SE 1989) nor sensitising to the skin (LLNA, Harlan/BASF SE 2012), further supporting the notion that there is a limited bioavailability of the substance via the dermal route.
Studies assessing genotoxicity (Ames-Test; BASF 1989, HPRT test in vitro; BASF 2012, Chromosome aberration in vitro; RCC/BASF 1998, Micronucleus Test in vivo; Sandoz 1985) were negative, i.e. there is no indication of a reactivity of the test substance or its metabolites with macromolecules under the chosen test conditions.
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