Sodium 3-morpholin-4-ylpropane-1-sulfonate

Flammability

Link to relevant study record(s)

Reference

Reference 1

Endpoint:

flammable gases

Data waiving:

study technically not feasible

Justification for data waiving:

the study does not need to be conducted because the substance is a solid

Reference 2

Endpoint:

flammable solids

Type of information:

experimental study

Adequacy of study:

key study

Reliability:

1 (reliable without restriction)

Rationale for reliability incl. deficiencies:

guideline study

Qualifier:

according to guideline

Guideline:

EU Method A.10 (Flammability (Solids))

Version / remarks:

1992

Deviations:

no

GLP compliance:

yes

Key result

Test procedure:

other: Test procedure not reported in SNIF.

Remarks on result:

other: The test item is not highly flammable.

Interpretation of results:

GHS criteria not met

Conclusions:

The test substance is not classified as flammable

Executive summary:

The flammability of the substance was determined in an experimental study  according to EU Methods A.10. The test substance is not classified as flammable according to Regulation (EC) No 1272/2008.

Reference 3

Endpoint:

pyrophoric liquids

Data waiving:

study technically not feasible

Justification for data waiving:

the study does not need to be conducted because the substance is a solid

Reference 4

Endpoint:

pyrophoric solids

Data waiving:

study scientifically not necessary / other information available

Justification for data waiving:

the study does not need to be conducted because the substance is known to be stable in contact with air at room temperature for prolonged periods of time (days) and hence, the classification procedure does not need to be applied

Reference 5

Endpoint:

self-heating substances / mixtures

Type of information:

experimental study

Adequacy of study:

key study

Study period:

from 2020-10-01 to 2020-10-27

Reliability:

1 (reliable without restriction)

Rationale for reliability incl. deficiencies:

guideline study

Qualifier:

according to guideline

Guideline:

other: VDI 2263 Sheet 1 Grewer Oven

Version / remarks:

1990

Deviations:

no

Qualifier:

according to guideline

Guideline:

UN Manual of Tests and Criteria: Test N.4 (Test method for self-heating substances)

Version / remarks:

2019

Deviations:

no

GLP compliance:

yes (incl. QA statement)

Key result

Test procedure:

100 mm sample cube at 140°C

Result:

negative outcome (no effect observed)

ln the investigation of self-ignition in the Grewer Oven for the pure test item first a small endothermic effect could be observed at a temperature of 40 °C and a second endothermic effect at approx. 220 °C which results into an exothermic effect starting at approx. 230 °C. This effect leads to a temperature increase up to 260 °C (corresponding temperature of the reference material 244 °C). A black residue remained in the wire basket after the test.

For the test item in mixture with Kieselguhr a weak endothermic effect could be observed starting at a temperature of approx. 40 °C and an exothermic effect starting at a temperature of approx. 220 °C which led to a temperature increase up to 650 °C (corresponding temperature of the reference material 238 °C). A grey residue remained in the wire basket after the test.

The table below summarizes the results of the Grewer Oven experiment.

Experiment	Onset self- ignition / °C	Maximum temperature / °C
Pure test item	approx. 230	260
Test item in mixture with Kieselguhr (1:1)	approx. 220	650

The test item indicated a self-ignition at atmospheric pressure starting at a temperature of approx. 230 °C. As the onset temperature of the exothermic effect is above 220 °C, it can be assumed that the test item would not indicate a self-heating up to a temperature of 140 °C in a 1 L wire basket.

Interpretation of results:

GHS criteria not met

Conclusions:

The test item does not have to be classified as self-heating substance.

Executive summary:

A study was conducted to determine the self-ignition of the test item according to VDI 2263 Sheet 1 Grewer Oven (1990). The test item indicated a self-ignition at atmospheric pressure starting at a temperature of approx. 230 °C. As the onset temperature of the exothermic effect is above 220 °C, it can be assumed that the test item would not indicate a self-heating up to a temperature of 140 °C in a 1 L wire basket. Therefore, the test item does not have to be classified as self-heating substance.

Reference 6

Endpoint:

substances / mixtures which in contact with water emit flammable gases

Data waiving:

study scientifically not necessary / other information available

Justification for data waiving:

the study does not need to be conducted because the experience in production or handling shows that the substance does not react with water, e.g. the substance is manufactured with water or washed with water

Description of key information

The substance has not to be classified as flammable gas, flammable liquid, flammable solid, flammable in contact with water, flammable aerosol, pyrophoric solid, pyrophoric liquid or self-heating substance.

Key value for chemical safety assessment

Flammability:

not classified

Additional information

 

Flammable gases (reference 4.13-1)

The test item is a solid at ambient conditions. This hazard class is only applicable for gases. Thus, the substance was not considered for classification as flammable gas.

 

Flammable liquid (reference 4.11-1)

The test item is a solid at ambient conditions. This hazard class is only applicable for liquids. Thus, the substance was not considered for classification as flammable liquid.

 

Flammable solids (reference 4.13-2)

The flammability of the substance was determined in an experimental study  according to EU Methods A.10. The test substance is not classified as flammable according to Regulation (EC) No 1272/2008.

Pyrophoric liquids (reference 4.13-3)

The test item is a solid at ambient conditions. This hazard class is only applicable for liquids. Thus, the substance was not considered for classification as flammable liquid.

 

Pyrophoric solids (reference 4.13-4)

In accordance with section 2.10.4 Annex I of Regulation (EC) No 1272/2008 and ECHA guidance on the application of CLP Criteria section 2.10.4.1 the classification procedure for pyrophoric solids need not to be applied when experience in manufacture or handling shows that the solid does not ignite spontaneously on coming into contact with air at normal temperatures (i.e. the solid is known to be stable at room temperature for prolonged periods of time (days)). Based on the experience in handling and use the substance is not known to ignite spontaneously when coming into contact with air at normal temperatures. Thus, no study was conducted and the substance was not considered for classification as pyrophoric solid.

 

Self-heating substances and mixtures (reference 4.13-5)

A study was conducted to determine the self-ignition of the test item according to VDI 2263 Sheet 1 Grewer Oven (1990). The test item indicated a self-ignition at atmospheric pressure starting at a temperature of approx. 230 °C. As the onset temperature of the exothermic effect is above 220 °C, it can be assumed that the test item would not indicate a self-heating up to a temperature of 140 °C in a 1 L wire basket. Therefore, the test item does not have to be classified as self-heating substance.

 

Substances which, in contact with water, emit flammable gases (reference 4.13-6)

In accordance with column 2 of REACH Annex VI and with Regulation (EC) No 1272/2008 Annex I section 2.12.4 and ECHA guidance on the application of CLP Criteria section 2.12.4.2 the classification procedure for this hazard class need not to be applied. Based on the experience in handling and use the substance does not react with water and in addition the test substance is not pyrophoric. Thus, no study was conducted and the substance was not considered for classification.

 

Flammable Aerosols

Section 2.4.2 of Guidance on the application on the CLP Criteria state as follows: “Aerosols, this means aerosol dispensers, are any non-refillable receptacles made of metal, glass or plastics and containing a gas compressed, liquefied or dissolved under pressure, with or without a liquid, paste or powder, and fitted with a release device allowing the contents to be ejected as solid or liquid particles in suspension in a gas, as a foam, paste or powder or in a liquid state or in a gaseous state." Thus, as the substance does not meet the definition for aerosol, the test for aerosols was waived. Consequently the substance has not to be considered for classification for this hazard class.

 

In conclusion, the substance have not to be considered as flammable gas, flammable liquid, flammable solid, flammable in contact with water, flammable aerosol, pyrophoric solid, pyrophoric liquid or self-heating substance.

Justification for classification or non-classification

Classification, Labelling, and Packaging Regulation (EC) No. 1272/2008

In accordance with Annex I Section 2.2, Section 2.3, Section 2.7, Section 2.9, Section 2.10 Section 2.11, Section 2.12 of Regulation (EC) No 1272/2008, as amended for the fifteenth time in Regulation (EU) 2020/1182, and UN GHS Rev 8 (2019) the test item has not to be classified as, readily combustible solid in class 4 Division 4.1, flammable liquid, self-heating substance in Class 4 Division 4.2, substances which in contact with water emit flammable gases in Class 4 Division 4.3, pyrophoric liquid, pyrophoric solid in class 4 Division 4.2, flammable gases in class 2 or as aerosol in class 2.