Dibenzo[d,f][1,3,2]dioxaphosphepin, 6,6'-[[3,3',5,5'-tetrakis(1,1-dimethylethyl)[1,1'-biphenyl]-2,2'-diyl]bis(oxy)]bis-

Acute Toxicity: dermal

Administrative data

Endpoint:

acute toxicity: dermal

Type of information:

experimental study

Adequacy of study:

key study

Reliability:

2 (reliable with restrictions)

Rationale for reliability incl. deficiencies:

other: Comparable to guideline study with acceptable restrictions

Data source

Reference

Reference Type:

study report

Title:

Unnamed

Year:

1987

Report date:

1987

Materials and methods

Test guideline

Qualifier:

equivalent or similar to guideline

Guideline:

OECD Guideline 434 (Acute Dermal Toxicity - Fixed Dose Procedure)

GLP compliance:

not specified

Test type:

standard acute method

Limit test:

no

Test material

Test material information

Constituent 1

Reference substance name:

-

EC Number:

482-400-9

EC Name:

-

Cas Number:

138776-88-2

Molecular formula:

C52H56O6P2

IUPAC Name:

9-[(3,3',5,5'-tetra-tert-butyl-2'-{8,10-dioxa-9-phosphatricyclo[9.4.0.0²,⁷]pentadeca-1(11),2(7),3,5,12,14-hexaen-9-yloxy}-[1,1'-biphenyl]-2-yl)oxy]-8,10-dioxa-9-phosphatricyclo[9.4.0.0²,⁷]pentadeca-1(11),2,4,6,12,14-hexaene

Test animals

Species:

rabbit

Strain:

New Zealand White

Sex:

male/female

Administration / exposure

Type of coverage:

occlusive

Vehicle:

corn oil

Duration of exposure:

24h

Doses:

4 and 8 g/kg bw

No. of animals per sex per dose:

5

Control animals:

no

Results and discussion

Effect levels

Effect levels 1

Sex:

male

Dose descriptor:

LD50

Effect level:

7 100 mg/kg bw

Based on:

test mat.

Effect levels 2

Sex:

female

Dose descriptor:

LD50

Effect level:

> 8 000 mg/kg bw

Based on:

test mat.

Any other information on results incl. tables

females: no deaths amongst 5 animals @ 8000 mg/kg bw.

males: 3 deaths amongts 5 animals @ 8000 mg/kg bw. No deaths amongst 5 animals @ 4000 mg/kg bw.

There were no local cutaneous effects. No signs of systemic toxicity preceded the death of 3 males and no signs were evident in survivors. Time to death ranged from one to seven days. Gross pathologic findings included pink to red lungs, gas-filled stomach and intestines (in one) and enlarged gall bladders (in2).

Applicant's summary and conclusion

Interpretation of results:

GHS criteria not met

Conclusions:

The acute dermal LD50 for male rabbits was 7100 mg/kg. For females, 8000 mg/kg did not produce deaths.

Executive summary:

The dermal LD50 for male rabbits was 7100 mg/kg bw. For females, the largest dose possible with the available sample, 8000 mg/kg bw did not produce death. There were no local cutaneous effects. No signs of systemic toxicity preceded the death of 3 males and no signs were evident in survivors. Time to death ranged from one to seven days. Gross pathologic findings included pink to red lungs, gas-filled stomach and intestines (in one) and enlarged gall bladders (in2).