Registration Dossier
Registration Dossier
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EC number: 482-400-9 | CAS number: 138776-88-2
Acute Toxicity: inhalation
Administrative data
- Endpoint:
- acute toxicity: inhalation
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Comparable to guideline study with acceptable restrictions
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 987
- Report date:
- 1987
Materials and methods
Test guideline
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- OECD Guideline 403 (Acute Inhalation Toxicity)
- GLP compliance:
- not specified
- Test type:
- fixed concentration procedure
- Limit test:
- yes
Test material
- Reference substance name:
- -
- EC Number:
- 482-400-9
- EC Name:
- -
- Cas Number:
- 138776-88-2
- Molecular formula:
- C52H56O6P2
- IUPAC Name:
- 9-[(3,3',5,5'-tetra-tert-butyl-2'-{8,10-dioxa-9-phosphatricyclo[9.4.0.0²,⁷]pentadeca-1(11),2(7),3,5,12,14-hexaen-9-yloxy}-[1,1'-biphenyl]-2-yl)oxy]-8,10-dioxa-9-phosphatricyclo[9.4.0.0²,⁷]pentadeca-1(11),2,4,6,12,14-hexaene
- Details on test material:
- Physical form of substance: Solid
Mass median aerodynamic diameter (for liq.+solid aerosol): 4.1 microns
Constituent 1
Test animals
- Species:
- rat
- Strain:
- Sprague-Dawley
- Sex:
- male/female
Administration / exposure
- Route of administration:
- inhalation
- Type of inhalation exposure:
- whole body
- Vehicle:
- other: unchanged (no vehicle)
- Analytical verification of test atmosphere concentrations:
- yes
- Duration of exposure:
- 4 h
- Concentrations:
- Comments: Dose concentrations ranged from 4.34 to 5.56 mg/l. 4.74 mg/l was the highest practical mean concentration that could be achieved in the chamber air.
- No. of animals per sex per dose:
- 5
- Control animals:
- no
Results and discussion
Effect levels
- Sex:
- male/female
- Dose descriptor:
- other: no deaths
- Effect level:
- 4.74 mg/L air
- Based on:
- test mat.
Applicant's summary and conclusion
- Interpretation of results:
- GHS criteria not met
- Conclusions:
- Inhalation exposure of male and female rats for 4 hours at a mean concentration of 4.74 mg/l resulted in no deaths or other significant signs of inhalation toxicity during the 14-day observation period.
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