Registration Dossier
Registration Dossier
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EC number: 445-680-3 | CAS number: 24088-77-5
Acute Toxicity: oral
Administrative data
- Endpoint:
- acute toxicity: oral
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 1 (reliable without restriction)
Data source
Reference
- Reference Type:
- other: Body responsible for the test
- Title:
- Unnamed
- Year:
- 2 003
- Report date:
- 2003
Materials and methods
Test guidelineopen allclose all
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 423 (Acute Oral toxicity - Acute Toxic Class Method)
- Qualifier:
- according to guideline
- Guideline:
- EU Method B.1 tris (Acute Oral Toxicity - Acute Toxic Class Method)
- Qualifier:
- according to guideline
- Guideline:
- EPA OPPTS 870.1100 (Acute Oral Toxicity)
- GLP compliance:
- yes (incl. QA statement)
- Test type:
- acute toxic class method
- Limit test:
- no
Test material
Constituent 1
Test animals
- Species:
- rat
- Strain:
- Wistar
- Sex:
- male/female
Administration / exposure
- Route of administration:
- oral: gavage
- Vehicle:
- other: 1% aqueous carboxymethyl cellulose.
Results and discussion
Effect levelsopen allclose all
- Sex:
- female
- Dose descriptor:
- other: mortality
- Effect level:
- 2 000 mg/kg bw
- Based on:
- test mat.
- Sex:
- male/female
- Dose descriptor:
- other: clinical signs
- Effect level:
- 200 mg/kg bw
- Based on:
- test mat.
- Mortality:
- Male: 200 mg/kg bw; Number of animals: 3; Number of deaths: 0
Female: 200 mg/kg bw; Number of animals: 3; Number of deaths: 0
Female: 2000 mg/kg bw; Number of animals: 3; Number of deaths: 2 - Clinical signs:
- other: - 2000 mg/kg: restlessness, lethargy, tremor, hunched and flat posture, uncoordinated movements, laboured respiration, squeaking - 200 mg/kg: hunched posture, uncoordinated movements The surviving animals had recovered from the symptoms between da
- Gross pathology:
- No abnormalities were found at macroscopic post mortem examination of the animals. Watery fluid in the uterus, found in one female, is related to a stage in the oestrous cycle and is a normal finding.
Applicant's summary and conclusion
- Interpretation of results:
- harmful
- Remarks:
- Migrated information Criteria used for interpretation of results: EU
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