(S)-p-mentha-1,8-diene

Partition coefficient

Link to relevant study record(s)

Reference

Endpoint:

partition coefficient

Type of information:

experimental study

Adequacy of study:

key study

Study period:

1999

Reliability:

2 (reliable with restrictions)

Rationale for reliability incl. deficiencies:

comparable to guideline study with acceptable restrictions

Remarks:

Study conducted similarly to OECD guideline 117 with minor deviations: no certificate of analysis of the test substance

Reason / purpose for cross-reference:

reference to same study

Qualifier:

equivalent or similar to guideline

Guideline:

OECD Guideline 117 (Partition Coefficient (n-octanol / water), HPLC Method)

Deviations:

yes

Remarks:

no certificate of analysis of the test substance

Principles of method if other than guideline:

Not applicable

GLP compliance:

not specified

Type of method:

HPLC method

Partition coefficient type:

octanol-water

Analytical method:

high-performance liquid chromatography

Key result

Type:

log Pow

Partition coefficient:

4.38

Temp.:

37 °C

pH:

7.2

Remarks on result:

other: standard error: 0.05

Details on results:

- Experimental log Kow (RP-HPLC) = 4.38 (S.E.: 0.05) at 37 °C
- Calculated log Kow = 4.36 (fragment method), 4.83 (atom /fragment contribution method) and 2.94 (atomistic method)

None

Conclusions:

Under the test conditions, the partition coefficient, log Kow, of (-)-limonene was determined to be 4.38 (S.E. = 0.05) at 37 °C. The calculated log Kow values of (-)-limonene were 4.36 (fragment method), 4.83 (atom /fragment contribution method) and 2.94 (atomistic method).

Executive summary:

A valid study was conducted to determine the partition coefficient of (-)-limonene by Reverse Phase High Performance Liquid Chromatographic method similarly to OECD Guideline 117.

 

Under the test conditions, the partition coefficient, log Kow, of (-)-limonene was determined to be 4.38 (S.E. = 0.05) at 37 °C. The calculated log Kow values of (-)-limonene were 4.36 (fragment method), 4.83 (atom /fragment contribution method) and 2.94 (atomistic method).

Description of key information

Key study: Test method similar to OECD 117: Log Kow determined using HPLC method : 4.38 at 37°C.

Key value for chemical safety assessment

Log Kow (Log Pow):

4.38

at the temperature of:

37 °C

Additional information

The key value for log Kow of l-limonene (4.38) was experimentally determined by an HPLC method similar to OECD 117 guideline.

The result is supported by other experimental values on l-limonene and on d-limonene, by read-across, its enantiomer which have the same physical properties.