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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Toxicological information

Acute Toxicity: oral

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Administrative data

Endpoint:
acute toxicity: oral
Type of information:
experimental study
Adequacy of study:
key study
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
other: Non-GLP study.

Data source

Reference
Reference Type:
study report
Title:
Unnamed
Report date:
1976

Materials and methods

Test guidelineopen allclose all
Qualifier:
equivalent or similar to guideline
Guideline:
EU Method B.1 (Acute Toxicity (Oral))
Qualifier:
equivalent or similar to guideline
Guideline:
OECD Guideline 401 (Acute Oral Toxicity)
GLP compliance:
no
Test type:
standard acute method
Limit test:
no

Test material

Constituent 1
Chemical structure
Reference substance name:
Chlorosulphonyl isocyanate
EC Number:
214-715-2
EC Name:
Chlorosulphonyl isocyanate
Cas Number:
1189-71-5
Molecular formula:
CClNO3S
IUPAC Name:
[(chlorosulfonyl)imino]methanone
Test material form:
gas under pressure: refrigerated liquefied gas
Details on test material:
- Name of test material: Chlorosulfonyl isocyanate

Test animals

Species:
rat
Sex:
male/female

Administration / exposure

Route of administration:
oral: gavage
Vehicle:
corn oil
Doses:
125, 200, 250, 500, 630, 800, 1000 mg/kg bw
No. of animals per sex per dose:
5 animals per sex and dose
Control animals:
no

Results and discussion

Effect levelsopen allclose all
Sex:
male
Dose descriptor:
LD0
Effect level:
500 mg/kg bw
Based on:
test mat.
Sex:
male
Dose descriptor:
LD50
Effect level:
630 mL/kg bw
Based on:
test mat.
95% CL:
580 - 720
Sex:
male
Dose descriptor:
LD100
Effect level:
800 mg/kg bw
Based on:
test mat.
Sex:
female
Dose descriptor:
LD0
Effect level:
500 mg/kg bw
Based on:
test mat.
Sex:
female
Dose descriptor:
LD50
Effect level:
680 mg/kg bw
Based on:
test mat.
95% CL:
620 - 740
Sex:
female
Dose descriptor:
LD100
Effect level:
800 mg/kg bw
Based on:
test mat.

Any other information on results incl. tables

- Fasted male albino rats, 200-300 grams: The animals dosed at levels ranging from 125 mg/kg bw to 250 mg/kg bw were languid for 8-12 hours. Lethargy was noted at 500 mg/kg bw. Nasal hemorrhage accompanied unkempt coats wetness in the hind quarters diarrhea and lethargy at 630 mg/kg bw and 800 mg/kg bw. Following intubation at 1000 mg/kg bw all animals became extremely lethargic and mortality was observed within 15 minutes.

- Fasted female albino rats, weights 200-300 grams: The animals dosed at levels ranging from 125 mg/kg bw to 250 mg/kg bw were languid for 8-12 hours. Lethargy was noted at 500 mg/kg bw. Nasal hemorrhage accompanied unkempt coats wetness in the hind quarters, diarrhea and lethargy at 630 mg/kg bw and 800 mg/kg bw. Following intubation at 1000 mg/kg bw all animals became extremely lethargic and mortality was observed within 15 minutes.

Applicant's summary and conclusion

Interpretation of results:
harmful
Remarks:
Migrated information Criteria used for interpretation of results: EU
Conclusions:
The LD50 was determined to be 630 mg/kg bw and 680 mg/kg bw for males and females, respectively.
Executive summary:

A study similar or equivalent to EU Method B.1 and OECD Guideline 401 (Acute Oral Toxicity) was carried out. Male and female rats were orally dosed with test item. The LD50 was determined to be 630 mg/kg bw and 680 mg/kg bw for males and females, respectively.