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Toxicological information

Skin irritation / corrosion

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Administrative data

Endpoint:
skin irritation: in vivo
Type of information:
migrated information: read-across from supporting substance (structural analogue or surrogate)
Adequacy of study:
key study
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
other: well documented and scientifically acceptable

Data source

Reference
Reference Type:
study report
Title:
Unnamed
Year:
1980
Report date:
1980

Materials and methods

Test guideline
Qualifier:
according to guideline
Guideline:
other: Code of Federal Regulations, Title 16, Section 16, Section 1500.41
Principles of method if other than guideline:
500 µl of the m-tolylisocyanate was applied on a 2.5 x 2.5 cm² area at the shaved (one side) and sacrificed (other side) trunk of 6 rabbits and fixed for 24 h. Reading was carried out 24 and 72 h after start of application.
GLP compliance:
no

Test material

Constituent 1
Chemical structure
Reference substance name:
m-tolyl isocyanate
EC Number:
210-676-0
EC Name:
m-tolyl isocyanate
Cas Number:
621-29-4
Molecular formula:
C8H7NO
IUPAC Name:
1-isocyanato-3-methylbenzene

Test animals

Species:
rabbit
Strain:
New Zealand White

Test system

Type of coverage:
occlusive
Preparation of test site:
shaved
Vehicle:
unchanged (no vehicle)
Controls:
not required
Duration of treatment / exposure:
24 hours
Observation period:
8 days
Number of animals:
6 animals

Results and discussion

In vivo

Results
Irritation parameter:
primary dermal irritation index (PDII)
Basis:
mean
Time point:
other: 24, 72 h
Score:
>= 3.8
Max. score:
8
Reversibility:
not fully reversible within: 8 d
Other effects:
White discoloration of the skin within 24 hours. Dryness, folding and red-brownish discoloration of the skin after 72 hours. dry eschar formation after 8 days and beginning of ablation. Beginning of reparation and cicatrisation

Any other information on results incl. tables

m-tolylisocyanate is corrosive to the skin

Applicant's summary and conclusion

Interpretation of results:
corrosive
Remarks:
Migrated information
Executive summary:

500 µl of the m-tolylisocyanate was applied on a 2.5 x 2.5 cm² area at the shaved (one side) and sacrificed (other side) trunk of 6 rabbits and fixed for 24 h. Reading was carried out 24 and 72 h after start of application.

Within 24 hours a white discoloration of the skin occurs, followed by dryness, folding and red-brownish discoloration of the skin after 72 hours. A dry eschar formation after 8 days and beginning of ablation was observed, with a beginning of reparation and scarring.

The primary irritation index was > 3.8. m-tolylisocyanate was regarded as corrosive to the skin.