p-tolyl isocyanate

Skin irritation / corrosion

Administrative data

Endpoint:

skin irritation: in vivo

Type of information:

migrated information: read-across from supporting substance (structural analogue or surrogate)

Adequacy of study:

key study

Reliability:

2 (reliable with restrictions)

Rationale for reliability incl. deficiencies:

other: well documented and scientifically acceptable

Data source

Reference

Reference Type:

study report

Title:

Unnamed

Year:

1980

Report date:

1980

Materials and methods

Test guideline

Qualifier:

according to guideline

Guideline:

other: Code of Federal Regulations, Title 16, Section 16, Section 1500.41

Principles of method if other than guideline:

500 µl of the m-tolylisocyanate was applied on a 2.5 x 2.5 cm² area at the shaved (one side) and sacrificed (other side) trunk of 6 rabbits and fixed for 24 h. Reading was carried out 24 and 72 h after start of application.

GLP compliance:

no

Test material

Test material information

Constituent 1

Reference substance name:

m-tolyl isocyanate

EC Number:

210-676-0

EC Name:

m-tolyl isocyanate

Cas Number:

621-29-4

Molecular formula:

C8H7NO

IUPAC Name:

1-isocyanato-3-methylbenzene

Test animals

Species:

rabbit

Strain:

New Zealand White

Test system

Type of coverage:

occlusive

Preparation of test site:

shaved

Vehicle:

unchanged (no vehicle)

Controls:

not required

Duration of treatment / exposure:

24 hours

Observation period:

8 days

Number of animals:

6 animals

Results and discussion

In vivo

Results

Irritation parameter:

primary dermal irritation index (PDII)

Basis:

mean

Time point:

other: 24, 72 h

Score:

>= 3.8

Max. score:

8

Reversibility:

not fully reversible within: 8 d

Other effects:

White discoloration of the skin within 24 hours. Dryness, folding and red-brownish discoloration of the skin after 72 hours. dry eschar formation after 8 days and beginning of ablation. Beginning of reparation and cicatrisation

Any other information on results incl. tables

m-tolylisocyanate is corrosive to the skin

Applicant's summary and conclusion

Interpretation of results:

corrosive

Remarks:

Migrated information

Executive summary:

500 µl of the m-tolylisocyanate was applied on a 2.5 x 2.5 cm² area at the shaved (one side) and sacrificed (other side) trunk of 6 rabbits and fixed for 24 h. Reading was carried out 24 and 72 h after start of application.

Within 24 hours a white discoloration of the skin occurs, followed by dryness, folding and red-brownish discoloration of the skin after 72 hours. A dry eschar formation after 8 days and beginning of ablation was observed, with a beginning of reparation and scarring.

The primary irritation index was > 3.8. m-tolylisocyanate was regarded as corrosive to the skin.