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EC number: 210-743-4 | CAS number: 622-58-2
Specific investigations: other studies
Administrative data
- Endpoint:
- mechanistic studies
- Type of information:
- experimental study
- Adequacy of study:
- supporting study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: special investigation
Data source
Reference
- Reference Type:
- publication
- Title:
- Experimental study on Skin sensitization with tolylene diisocyanate
- Author:
- Ohsawa T, Ishizu S
- Year:
- 1 983
- Bibliographic source:
- Tokyo Joshi Ika Daigaku Zasshi 53, 273-277, 1983
Materials and methods
- Principles of method if other than guideline:
- The present study compared the skin-sensitizing ability of three (o-, m-, p-) tolylisocyanate (TI) isomers with TDI in mice, in order to investigate whether the 2 isocyanate groups are both necessary or one of them plays the dominant part in skin sensitization with TDI.
- GLP compliance:
- not specified
- Type of method:
- in vivo
- Endpoint addressed:
- skin sensitisation
Test material
- Reference substance name:
- o-tolyl isocyanate
- EC Number:
- 210-389-0
- EC Name:
- o-tolyl isocyanate
- Cas Number:
- 614-68-6
- Molecular formula:
- C8H7NO
- IUPAC Name:
- 1-isocyanato-2-methylbenzene
- Reference substance name:
- m-tolyl isocyanate
- EC Number:
- 210-676-0
- EC Name:
- m-tolyl isocyanate
- Cas Number:
- 621-29-4
- Molecular formula:
- C8H7NO
- IUPAC Name:
- 1-isocyanato-3-methylbenzene
- Reference substance name:
- p-tolyl isocyanate
- EC Number:
- 210-743-4
- EC Name:
- p-tolyl isocyanate
- Cas Number:
- 622-58-2
- Molecular formula:
- C8H7NO
- IUPAC Name:
- 1-isocyanato-4-methylbenzene
Constituent 1
Constituent 2
Constituent 3
Test animals
- Species:
- mouse
- Strain:
- not specified
- Sex:
- not specified
Administration / exposure
- Route of administration:
- other: no data
- Vehicle:
- other: no data
- Duration of treatment / exposure:
- no data
- Frequency of treatment:
- no data
- Post exposure period:
- no data
- No. of animals per sex per dose:
- no data
Results and discussion
- Details on results:
- All 3 TI isomers resulted to have skin-sensitising ability, though a weaker degree compared to that of TDI. However, there was no significant difference among the 3 isomers.
Any other information on results incl. tables
All 3 TI isomers resulted to have skin-sensitising ability, though a weaker degree compared to that of TDI. However, there was no significant difference among the 3 isomers.
Applicant's summary and conclusion
- Executive summary:
All 3 TI isomers resulted to have skin-sensitising ability, though a weaker degree compared to that of TDI. However, there was no significant difference among the 3 isomers.
These results suggest that the presence of one isocyanate group is enough to cause skin sensitisation, despite of its position on the benzene ring.
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