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Toxicity to terrestrial arthropods

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Description of key information

The expected NOEC for cetrimonium bromide on terrestrial arthropods are estimated to be >308 mg/kg extrapolated from data on toxicity of dodecyltrimethylammonium bromide to terrestrial arthropods.

In the experiment with dodecyltrimethylammonium chloride and the surfactant spiked sediment, exposure up to 3084 mg/kg sediment gave no significant effect on larval emergence of the species Chironomus riparius (midge). Read across to cetrimonium bromide from the results obtained for the sediment spiked with dodecyltrimethylammonium chloride are done based on the observations from other studies including C12-C18 mono alkyl quaternary ammonium compounds, showing that the toxicity of cetrimonium bromide (C16) is higher than the toxicity of the structurally alike halides of shorter alkyl chain. It is anticipated from the results from other studies that the toxicity of cetrimonium bromide to terrestrial arthropods is 10 times higher than the toxicity of dodecyltrimethyl ammonium bromide. The expected NOEC for cetrimonium bromide on terrestrial arthropods are therefore estimated to be >308 mg/kg.

Key value for chemical safety assessment

Long-term EC10, LC10 or NOEC for soil dwelling arthropods:
308 mg/kg soil dw

Additional information

In the experiment with dodecyltrimethylammonium chloride and the surfactant spiked sediment, exposure up to 3084 mg/kg sediment gave no significant effect on larval emergence of the species Chironomus riparius (midge). Read across to cetrimonium bromide from the results obtained for the sediment spiked with dodecyltrimethylammonium chloride are done based on the observations from other studies including C12-C18 mono alkyl quaternary ammonium compounds, showing that the toxicity of cetrimonium bromide (C16) is higher than the toxicity of the structurally alike halides of shorter alkyl chain. It is anticipated from the results from other studies that the toxicity of cetrimonium bromide to invetebrates is 10 times higher than the toxicity of dodecyltrimethyl ammonium bromide. The expected NOEC for cetrimonium bromide on terrestrial arthropods are therefore estimated to be >308 mg/kg.