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EC number: 278-575-4 | CAS number: 76918-62-2
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Toxicity to microorganisms
Administrative data
- Endpoint:
- activated sludge respiration inhibition testing
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- other: Study according to OECD Guideline 209
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 994
- Report date:
- 1995
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 209 (Activated Sludge, Respiration Inhibition Test
- Deviations:
- no
- GLP compliance:
- yes
Test material
- Reference substance name:
- Sodium N-(2,3-dihydro-2-oxo-1H-benzimidazol-5-yl)-3-hydroxynaphthalene-2-carboxamidate
- EC Number:
- 278-575-4
- EC Name:
- Sodium N-(2,3-dihydro-2-oxo-1H-benzimidazol-5-yl)-3-hydroxynaphthalene-2-carboxamidate
- Cas Number:
- 76918-62-2
- Molecular formula:
- C18H13N3O3.Na
Constituent 1
Sampling and analysis
- Analytical monitoring:
- no
Test solutions
- Vehicle:
- no
- Details on test solutions:
- PREPARATION OF TEST SOLUTION
Preparation of the saturated solution: The test item was weighed out (500 and 1000 mg/L ) directly into the test vessels.
Test organisms
- Test organisms (species):
- activated sludge of a predominantly domestic sewage
- Details on inoculum:
- - Origin: Municipal sewage treatment plant of Sindlingen (Frankfurt)
- non-adapted activated sludge, receives predominantly municipal sewage and hardly industrial chemical waste
Study design
- Test type:
- static
- Limit test:
- yes
- Total exposure duration:
- 3 h
Test conditions
- Test temperature:
- 19,2 - 20,6°C
- pH:
- 7,0 - 7,1
- Nominal and measured concentrations:
- Nominal concentration: 500 mg/L , 1000 mg/L
- Details on test conditions:
- TEST SYSTEM
- Test vessel:
- glass flasks, diameter 60 mm, height 170 mm
- fill volume: appr. 480 mL
- Aeration: permanent
- No. of vessels per concentration (replicates): 2
- No. of vessels per control (replicates): 3
TEST MEDIUM
- according to Directive 88/302/EEC, Part C and OECD guideline 209
EFFECT PARAMETERS MEASURED (with observation intervals if applicable) :
- the pH-value of the activated sludge was measured prior to testing
- the temperature in the measuring cell was determined once durcing the measurement
TEST CONCENTRATIONS
- Test concentrations: 500 mg/L, 1000 mg/L
- 3 control replicates without test item were included. - Reference substance (positive control):
- yes
- Remarks:
- 3,5-dichlorophenol
Results and discussion
Effect concentrationsopen allclose all
- Duration:
- 3 h
- Dose descriptor:
- EC50
- Effect conc.:
- > 1 000 mg/L
- Nominal / measured:
- nominal
- Conc. based on:
- test mat.
- Basis for effect:
- inhibition of total respiration
- Remarks:
- respiration rate
- Duration:
- 3 h
- Dose descriptor:
- other: EC20
- Effect conc.:
- > 1 000 mg/L
- Nominal / measured:
- nominal
- Conc. based on:
- test mat.
- Basis for effect:
- inhibition of total respiration
- Remarks:
- respiration rate
- Duration:
- 3 h
- Dose descriptor:
- other: EC80
- Effect conc.:
- > 1 000 mg/L
- Nominal / measured:
- nominal
- Conc. based on:
- test mat.
- Basis for effect:
- inhibition of total respiration
- Remarks:
- respiration rate
Any other information on results incl. tables
Table 1: Respiration rates and inhibition of respiration of test and reference item concentrations
|
Respiration Rate [mg O2/L x h] |
Inhibition [%] |
Mean |
Control 1 |
52.8 |
- |
54.4 mg O2/L x h |
Control 2 |
55.2 |
- |
|
Control 3 |
55.2 |
- |
|
DCP* 5 mg/L |
42.0 |
22.8 |
- |
DCP 20 mg/L |
18.0 |
66.9 |
- |
DCP 30 mg/L |
15.6 |
71.3 |
- |
Test item 500 mg/L |
50.4 |
7.4 |
6.2 % |
Test item 500 mg/L |
51.6 |
5.1 |
|
Test item 1000 mg/L |
55.2 |
-1.5 |
-1.5 % |
Test item 1000 mg/L |
55.2 |
-1.5 |
DCP = 3,5 -dichlorophenol
Applicant's summary and conclusion
- Conclusions:
- The test item is not toxic at concentration = 1000 mg/L to activated sludge of a municipal sewage treatment plant.
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