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EC number: 278-575-4 | CAS number: 76918-62-2
Partition coefficient
Administrative data
- Endpoint:
- partition coefficient
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- other: According to OECD 107
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 2 010
- Report date:
- 2010
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 107 (Partition Coefficient (n-octanol / water), Shake Flask Method)
- Type of method:
- shake-flask method to: flask method
- Partition coefficient type:
- octanol-water
Test material
- Reference substance name:
- Sodium N-(2,3-dihydro-2-oxo-1H-benzimidazol-5-yl)-3-hydroxynaphthalene-2-carboxamidate
- EC Number:
- 278-575-4
- EC Name:
- Sodium N-(2,3-dihydro-2-oxo-1H-benzimidazol-5-yl)-3-hydroxynaphthalene-2-carboxamidate
- Cas Number:
- 76918-62-2
- Molecular formula:
- C18H13N3O3.Na
Constituent 1
Study design
- Analytical method:
- photometric method
Results and discussion
Partition coefficient
- Type:
- log Pow
- Partition coefficient:
- 2.02
- Temp.:
- 23 °C
- pH:
- ca. 7
- Remarks on result:
- other: mean
Any other information on results incl. tables
Table 1: Results
no. |
stock solution [ml] |
n-octanol [ml] |
conc. in water phase [mg/l] |
conc. in n-octanol phase [mg/l] |
log pow |
A1 |
5 |
10 |
10,5 |
29,4 |
0,45 |
A2 |
5 |
10 |
11,9 |
28,9 |
0,38 |
B1 |
10 |
10 |
28,7 |
40,4 |
0,15 |
B2 |
10 |
10 |
28,3 |
40,3 |
0,15 |
C1 |
20 |
10 |
40,9 |
53,1 |
0,11 |
C2 |
20 |
10 |
42,1 |
54,4 |
0,11 |
mean |
- |
- |
- |
- |
0,23 |
Table 2: Recovery rate
no. |
test substance stock solution [mg] |
test substance in water phase [mg] |
test substance in n-octanol phase [mg] |
sum [mg] |
recovery rate [%] |
A1 |
0,35 |
0,05 |
0,29 |
0,35 |
98 |
A2 |
0,35 |
0,06 |
0,29 |
0,35 |
98 |
B1 |
0,71 |
0,29 |
0,40 |
0,69 |
97 |
B2 |
0,71 |
0,28 |
0,40 |
0,69 |
97 |
C1 |
1,42 |
0,82 |
0,53 |
1,35 |
95 |
C2 |
1,42 |
0,84 |
0,54 |
1,38 |
98 |
Applicant's summary and conclusion
- Executive summary:
The partition coefficient (log pow) of the test substance was determined according to OECD Guideline 107.
Result log pow = 0.23 (mean of 6 measurements).
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