Registration Dossier
Registration Dossier
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EC number: 231-869-6 | CAS number: 7773-01-5
Additional toxicological data
Administrative data
- Endpoint:
- additional toxicological information
- Type of information:
- experimental study
- Adequacy of study:
- supporting study
- Reliability:
- 3 (not reliable)
- Rationale for reliability incl. deficiencies:
- other: Not to GLP, not to guideline. Insufficient methodology is provided.
Data source
Reference
- Reference Type:
- publication
- Title:
- Experimental investigation of manganese chloride toxicity
- Author:
- Pashinskii VG, Tuzlukov AP, Rasskhin VM, Arefe'eva AK, Sedova KS, Motovilova VG and Fil'sanova GA
- Year:
- 1 975
- Bibliographic source:
- Russian Pharmacology and Toxicology , 38(5): 221-224
Materials and methods
- Type of study / information:
- Toxicological tests
Test guideline
- Qualifier:
- no guideline followed
- Principles of method if other than guideline:
- The study investigates the toxicity of MnCl2.
- GLP compliance:
- no
Test material
- Reference substance name:
- Manganese dichloride
- EC Number:
- 231-869-6
- EC Name:
- Manganese dichloride
- Cas Number:
- 7773-01-5
- Molecular formula:
- Cl2Mn
- IUPAC Name:
- manganese(2+) dichloride
Constituent 1
Results and discussion
Any other information on results incl. tables
The LD50 of MnCl2 to mice was found to be 255 mg/kg and in rats was 700 mg/kg. The animals died within 3 -5 days of administration of the toxic doses.
Administration of MnCl2 to rabbits at daily doses of 0.5 and 5 mg/kg for 2 months produced no changes in the animals behaviour or condition. No animal died during this experiment.
The blood levels of manganese after administration of 0.5 mg/kg MnCl2 were identical to those in control group animals. When the higher dose of MnCl2 was used the Mn blood level rose.
Rabbits treated with MnCl2 for 2 months showed no variations in the macro- and microexaminations of various body organs and tissues, the weight and histological structure of internal secretory glands and blood sugar levels compared to the controls.
The local irritant action in response to administration of MnCl2 disappears spontaneously following its withdrawal on completion of a course of therapy.
Applicant's summary and conclusion
- Conclusions:
- The LD50 of MnCl2 to mice was found to be 255 mg/kg and in rats was 700 mg/kg.
Administration of MnCl2 to rabbits at daily doses of 0.5 and 5 mg/kg for 2 months produced no changes in the animals behaviour or condition.
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