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EC number: 231-869-6 | CAS number: 7773-01-5
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Endpoint summary
Administrative data
Description of key information
Extensive acute oral data is available on the manganese dichloride, allowing selection of an oral LD50 on which to base classification. Inhalation LC50 data is available for a surrogate material (manganese sulphate), and an estimate of the classification is made for the dermal route using dermal and oral absorption, and acute oral toxicity.
Key value for chemical safety assessment
Acute toxicity: via oral route
Link to relevant study records
- Endpoint:
- acute toxicity: oral
- Type of information:
- experimental study
- Adequacy of study:
- weight of evidence
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Study not conducted according to GLP or a current guideline, for example non-standard dose levels have been used. However, study meets generally accepted scientific standards, is well documented and acceptable for assessment.
- Qualifier:
- no guideline followed
- Principles of method if other than guideline:
- Female rats were exposed to manganese chloride, either by a single oral dose or by three subsequent doses at 3-hour intervals. Six dose levels were used and each dose level was tested on 6 animals.
- GLP compliance:
- not specified
- Test type:
- standard acute method
- Limit test:
- no
- Species:
- rat
- Strain:
- not specified
- Sex:
- female
- Details on test animals or test system and environmental conditions:
- No data
- Route of administration:
- oral: gavage
- Vehicle:
- water
- Details on oral exposure:
- Animals were split into two groups with one group receiving a single oral dose and the other receiving 3 subsequent doses at 3 hourly intervals.
- Doses:
- single dose group: 156, 196, 247, 312, 392, 495 mg Mn / kg bw
three dose group: 94, 118, 149, 187, 236, 296 mg Mn / kg bw (total daily dose for each dose group: 279, 352, 443, 558, 703, 886 mg Mn / kg bw) - No. of animals per sex per dose:
- 6 females per dose
- Control animals:
- not specified
- Sex:
- female
- Dose descriptor:
- LD50
- Effect level:
- 236 mg/kg bw
- 95% CL:
- 210 - 265
- Remarks on result:
- other: single dose group
- Sex:
- female
- Dose descriptor:
- LD50
- Effect level:
- 702 mg/kg bw
- 95% CL:
- 598 - 825
- Remarks on result:
- other: 3 subsequent doses
- Mortality:
- please see table 1 below.
- Clinical signs:
- other: No data
- Gross pathology:
- No data
- Other findings:
- No data
- Conclusions:
- Results suggest that as a single dose MnCl2 is more harmful than 3 subsequent doses.
Reference
Mortality rate after single or fractioned administration of MnCl2:
Dosing schedule |
mg Mn / kg bw |
Mortality Rate ( / 6 ) |
||||||
total daily dose |
single dose |
Days after exposure |
||||||
1 |
2 |
3 |
4 |
5 |
6 |
|||
Single dose |
156 |
156 |
0/6 |
0/6 |
0/6 |
0/6 |
0/6 |
0/6 |
196 |
196 |
0/6 |
0/6 |
0/6 |
0/6 |
0/6 |
0/6 |
|
247 |
247 |
2/6 |
5/6 |
5/6 |
5/6 |
5/6 |
5/6 |
|
312 |
312 |
3/6 |
4/6 |
4/6 |
4/6 |
4/6 |
4/6 |
|
392 |
392 |
6/6 |
6/6 |
6/6 |
6/6 |
6/6 |
6/6 |
|
495 |
495 |
6/6 |
6/6 |
6/6 |
6/6 |
6/6 |
6/6 |
|
Three subsequent doses |
279 |
94 |
0/6 |
0/6 |
0/6 |
0/6 |
0/6 |
0/6 |
352 |
118 |
0/6 |
0/6 |
0/6 |
0/6 |
0/6 |
0/6 |
|
443 |
149 |
0/6 |
0/6 |
0/6 |
0/6 |
0/6 |
0/6 |
|
558 |
187 |
1/6 |
1/6 |
1/6 |
1/6 |
1/6 |
1/6 |
|
703 |
236 |
2/6 |
3/6 |
3/6 |
3/6 |
3/6 |
3/6 |
|
886 |
297 |
5/6 |
5/6 |
5/6 |
5/6 |
5/6 |
5/6 |
Endpoint conclusion
- Endpoint conclusion:
- adverse effect observed
- Dose descriptor:
- LD50
- Value:
- 236 mg/kg bw
- Quality of whole database:
- The key study was not conducted according to GLP or a current guideline, for example non-standard dose levels have been used. However, the study meets generally accepted scientific standards, is well documented and acceptable for assessment.
Acute toxicity: via inhalation route
Link to relevant study records
- Endpoint:
- acute toxicity: inhalation
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 26 March 2010 to 20 April 2010.
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- other: Study conducted in compliance with agreed protocols, with no or minor deviations from standard test guidelines and/or minor methodological deficiencies, which do not affect the quality of the relevant results.
- Justification for type of information:
- See the read-across report attached in Section 13.
- Reason / purpose for cross-reference:
- other: read-across target
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 403 (Acute Inhalation Toxicity)
- Deviations:
- no
- Qualifier:
- according to guideline
- Guideline:
- EU Method B.2 (Acute Toxicity (Inhalation))
- Deviations:
- no
- GLP compliance:
- yes (incl. QA statement)
- Remarks:
- Date of GLP inspection: 15/09/2009. Date of signature on GLP certificate: 26/11/2009
- Test type:
- standard acute method
- Limit test:
- yes
- Species:
- rat
- Strain:
- Wistar
- Sex:
- male/female
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
- Source: Male and female HsdHan : WIST strain rats were supplied by Harlan UK Ltd, Oxon, UK.
- Age at study initiation: Approximately eight to twelve weeks old.
- Weight at study initiation: Within the weight range of 200g to 350g.
- Housing: The animals were housed in groups of five by sex in solid-floor polypropylene cages with stainless steel lids, furnished with softwood flakes (Datesand Ltd., Cheshire, UK) and provided with environmental enrichment items: wooden chew blocks and cardboard “fun tunnels” (Datesand Ltd., Cheshire, UK).
- Diet (e.g. ad libitum): With the exception of the exposure period, free access to food (Harlan 2014 Rodent Diet, Harlan UK Ltd, Oxon, UK) was allowed throughout the study.
- Water (e.g. ad libitum): With the exception of the exposure period, free access to mains drinking water was allowed throughout the study.
- Acclimation period: At least five days.
ENVIRONMENTAL CONDITIONS
- Temperature (°C): The environmental controls were set to achieve values of 19 - 25°C
- Humidity (%): The environmental controls were set to achieve values of 30 - 70% relative humidity.
- Air changes (per hr): At least fifteen changes per hour.
- Photoperiod (hrs dark / hrs light): Lighting was controlled to give twelve hours continuous light and twelve hours darkness. - Route of administration:
- inhalation: dust
- Type of inhalation exposure:
- nose only
- Vehicle:
- other: no vehicle
- Details on inhalation exposure:
- GENERATION OF TEST ATMOSPHERE / CHAMBER DESCRIPTION
- Exposure apparatus:
A dust atmosphere was produced from the test material using a SAG 410 Solid Aerosol Generator (TOPAS GmbH, Dresden, Germany) located adjacent to the exposure chamber. The SAG 410 was connected to a metered compressed air supply. The cylindrical exposure chamber had a volume of approximately 30 litres (dimensions: 28 cm diameter x 50 cm high). The concentration within the chamber was controlled by adjusting the test material feed rate from the SAG 410. The extract from the exposure chamber passed through a ‘scrubber’ trap and was connected with a high efficiency filter to a metered exhaust system. The chamber was maintained under negative pressure.
- Exposure chamber volume:
Approximately 30 litres (dimensions: 28 cm diameter x 50 cm high).
- Method of holding animals in test chamber:
Each rat was individually held in a tapered, polycarbonate restraining tube fitted onto a single tier of the exposure chamber and sealed by means of a rubber ‘O’ ring. Only the nose of each animal was exposed to the test atmosphere.
- Source and rate of air:
Compressed air was supplied by means of an oil free compressor and passed through a water trap and respiratory quality filters before it was introduced to the SAG 410.
- Method of conditioning air:
Compressed air passed through a water trap and respiratory quality filters.
- System of generating particulates/aerosols:
A dust atmosphere was produced from the test material using a SAG 410 Solid Aerosol Generator (TOPAS GmbH, Dresden, Germany) located adjacent to the exposure chamber. The SAG 410 was connected to a metered compressed air supply.
- Method of particle size determination:
The particle size of the generated atmosphere inside the exposure chamber was determined three times during the exposure period using a Marple Personal Cascade Impactor (Westech IS Ltd, Beds., UK).
- Treatment of exhaust air:
Filtered.
- Temperature, humidity, pressure in air chamber:
The temperature and relative humidity inside the exposure chamber were measured by an electronic thermometer/humidity meter (Hanna Instruments Ltd, Beds., UK) located in a vacant port in the animals’ breathing zone of the chamber and recorded every thirty minutes throughout the four-hour exposure period.
TEST ATMOSPHERE
- Brief description of analytical method used:
The actual chamber concentration was measured at regular intervals during the exposure period. The gravimetric method used glass fibre filters placed in a filter holder. The holder was temporarily sealed in a vacant port in the exposure chamber in the animals’ breathing zone and a suitable, known volume of exposure chamber air was drawn through the filter using a vacuum pump.
Each filter was weighed before and after sampling in order to calculate the weight of collected test material. The difference in the two weights, divided by the volume of atmosphere sampled, gave the actual chamber concentration.
The nominal chamber concentration was calculated by dividing the mass of test material used by the total volume of air passed through the chamber.
- Samples taken from breathing zone: yes
VEHICLE
Not applicable.
TEST ATMOSPHERE (if not tabulated)
- Particle size distribution: Inhalable fraction (% < 4 µm): 53.8%
- MMAD (Mass median aerodynamic diameter): 3.64 µm - Analytical verification of test atmosphere concentrations:
- yes
- Duration of exposure:
- 4 h
- Concentrations:
- Mean achieved atmosphere concentration (mg/L): 4.98
Mean Mass Median Aerodynamic Diameter (MMAD) = 3.64 µm
Geometric Standard Deviation (GSD) = 2.74
Predicted amount less than 4 µm = 53.8% - No. of animals per sex per dose:
- 5 per sex per dose
- Control animals:
- no
- Details on study design:
- - Duration of observation period following administration: 14 days
- Frequency of observations and weighing: All animals were observed for clinical signs at hourly intervals during exposure, immediately on removal from the restraining tubes at the end of exposure, one hour after termination of exposure and subsequently once daily for fourteen days. Any evidence of overt toxicity was recorded at each observation.
Individual bodyweights were recorded prior to treatment on the day of exposure and on Days 7 and 14.
- Necropsy of survivors performed: At the end of the fourteen day observation period the animals were killed by intravenous overdose of sodium pentobarbitone. All animals were subjected to a full external and internal examination, and any macroscopic abnormalities were recorded. The respiratory tract was subjected to a detailed macroscopic examination for signs of irritancy or local toxicity. - Statistics:
- Data evaluations included the relationship, if any, between the animals’ exposure to the test material and the incidence and severity of all abnormalities including behavioural and clinical observations, necropsy findings, bodyweight changes, mortality and any other toxicological effects.
Using the mortality data obtained, an estimate of the acute inhalation median lethal concentration (LC50) of the test material was made. - Preliminary study:
- Not applicable
- Sex:
- male/female
- Dose descriptor:
- LC50
- Effect level:
- > 4.45 mg/L air
- Based on:
- other: MnSO4 (as anhydrous)
- Exp. duration:
- 4 h
- Mortality:
- No deaths occurred in a group of ten rats exposed to a mean achieved atmosphere concentration of 4.98 mg MnSO4.H2O/L for four hours.
- Clinical signs:
- other: Signs of hunched posture and pilo-erection are commonly seen in animals for short periods on removal from the chamber following 4-hour inhalation studies. Wet fur is commonly recorded both during and for a short period after exposure. These observations a
- Body weight:
- Variations in bodyweight gain are frequently seen for female animals of this strain and age during this type of study and, in isolation, are considered not to be significant.
All males and four female animals exhibited a slight bodyweight loss or reduced bodyweight gain during Week 1. With the exception of one female animal which exhibited a loss during Week 2 (this animal exhibited normal development during Week 1) animals recovered to exhibit normal development. - Gross pathology:
- With the exception of one instance of dark patches on the lungs, no macroscopic abnormalities were detected at necropsy.
- Interpretation of results:
- not classified
- Remarks:
- Criteria used for interpretation of results: EU
- Conclusions:
- No deaths occurred in a group of ten rats exposed to a mean achieved atmosphere concentration of 4.98 mg/L for four hours. It was therefore considered that the acute inhalation median lethal concentration (4 hr LC50) of MnSO4.H2O, in the HsdHan : WIST strain rat, was greater than 4.98 mg/L. The equivalent LC50 value for the anhydrous form of this material is considered to be >4.45 mg/L.
On the basis of this result, MnSO4 does not meet the criteria for classification in the EU in accordance with both Council Directive 67/548/EEC as amended and Regulation (EC) No 1272/2008 and will not require labelling for inhalation toxicity. - Executive summary:
Introduction. A study was performed to assess the acute inhalation toxicity of the test material. The method used followed that described in the OECD Guidelines for Testing of Chemicals (1981) No. 403 “Acute Inhalation Toxicity” referenced as Method B2 (Inhalation) of Commission Regulation (EC) No. 440/2008.
Methods. A group of ten HsdHan: WIST strain rats (five males and five females) was exposed to a dust atmosphere. The animals were exposed for four hours using a nose only exposure system, followed by a fourteen day observation period.
Results. The mean achieved atmosphere concentration was as follows:
Atmosphere Concentration
Mean Achieved (mg/L)
Standard Deviation
Nominal (mg/L)
4.98
0.88
57.2
The characteristics of the achieved atmosphere were as follows:
Mean Achieved Atmosphere Concentration (mg/L)
Mean Mass Median Aerodynamic Diameter (µm)
Inhalable Fraction
(% <4 µm)
Geometric Standard Deviation
4.98
3.64
53.8
2.74
The mortality data were summarised as follows:
Mean Achieved Atmosphere Concentration (mg/L)
Deaths
Male
Female
Total
4.98
0/5
0/5
0/10
Clinical Observations. Common abnormalities noted during the study included increased respiratory rate, hunched posture, pilo-erection and wet fur. Animals recovered quickly to appear normal from Day 3 post-exposure.
Bodyweight. All males and four female animals exhibited a slight bodyweight loss or reduced bodyweight gain during Week 1. With the exception of one female animal which exhibited a loss during Week 2 (this animal exhibited normal development during Week 1) animals recovered to exhibit normal development.
Necropsy. With the exception of one instance of dark patches on the lungs, no macroscopic abnormalities were detected at necropsy.
Conclusion. No deaths occurred in a group of ten rats exposed to a mean achieved atmosphere concentration of4.98mg/L for four hours. It was therefore considered that the acute inhalation median lethal concentration (4 hr LC50) of MnSO4, in the HsdHan: WIST strain rat, was greater than 4.98mg/L. The equivalent LC50 value for the anhydrous form of this material is considered to be >4.45mg/L.
On the basis of this result, MnSO4does not meet the criteria for classification in the EU in accordance with both Council Directive 67/548/EEC as amended and Regulation (EC) No 1272/2008 and will not require labelling for inhalation toxicity.
Reference
Mortality Data
Mean Achieved Atmosphere Concentration (mg/L) |
Sex |
Deaths During Exposure |
Deaths Post Exposure (1 Hour) |
Deaths During Day of Observation |
Total Deaths |
|||||||
1 |
2 |
3 |
4 |
5 |
6 |
7 |
8-14 |
|||||
4.98 |
Male |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
0/10 |
Female |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
KEY TO CLINICAL OBSERVATIONS
H |
= |
hunched posture |
P |
= |
pilo-erection |
Ri |
= |
increased respiratory rate |
Wf |
= |
wet fur |
0 |
= |
no abnormalities detected |
Individual Clinical Observations (Day of Exposure)
Mean Achieved Atmosphere Concentration (mg/L) |
Animal Number and Sex |
Hours During Exposure |
On Removal From Chamber |
One Hour Post-Exposure |
||
1 |
2 |
3 |
||||
4.98 |
1 Male |
Wf |
Wf |
Wf |
Wf H P Ri |
Wf H P Ri |
2 Male |
Wf |
Wf |
Wf |
Wf H P Ri |
Wf H P Ri |
|
3 Male |
Wf |
Wf |
Wf |
Wf H P Ri |
Wf H P Ri |
|
4 Male |
Wf |
Wf |
Wf |
Wf H P Ri |
Wf H P Ri |
|
5 Male |
Wf |
Wf |
Wf |
Wf H P Ri |
Wf H P Ri |
|
6 Female |
Wf |
Wf |
Wf |
Wf H P Ri |
Wf H P Ri |
|
7 Female |
Wf |
Wf |
Wf |
Wf H P Ri |
Wf H P Ri |
|
8 Female |
Wf |
Wf |
Wf |
Wf H P Ri |
Wf H P Ri |
|
9 Female |
Wf |
Wf |
Wf |
Wf H P Ri |
Wf H P Ri |
|
10 Female |
Wf |
Wf |
Wf |
Wf H P Ri |
Wf H P Ri |
Individual Clinical Observations (Recovery Period)
Mean Achieved Atmosphere Concentration (mg/L) |
Animal Number and Sex |
Days Post Exposure |
|||||||
1 |
2 |
3 |
4 |
5 |
6 |
7 |
8-14 |
||
4.98 |
1 Male |
H Ri |
H |
0 |
0 |
0 |
0 |
0 |
0 |
2 Male |
H Ri |
H |
0 |
0 |
0 |
0 |
0 |
0 |
|
3 Male |
H P Ri |
H |
0 |
0 |
0 |
0 |
0 |
0 |
|
4 Male |
H Ri |
H |
0 |
0 |
0 |
0 |
0 |
0 |
|
5 Male |
H Ri |
H |
0 |
0 |
0 |
0 |
0 |
0 |
|
6 Female |
H P Ri |
H |
0 |
0 |
0 |
0 |
0 |
0 |
|
7 Female |
H Ri |
H |
0 |
0 |
0 |
0 |
0 |
0 |
|
8 Female |
H P Ri |
H |
0 |
0 |
0 |
0 |
0 |
0 |
|
9 Female |
H P Ri |
H |
0 |
0 |
0 |
0 |
0 |
0 |
|
10 Female |
H Ri |
H |
0 |
0 |
0 |
0 |
0 |
0 |
Individual Bodyweights
Mean Achieved Atmosphere Concentration (mg/L) |
Animal Number and Sex |
Bodyweight (g) on Day: |
Increment (g) During Week: |
|||
0 |
7 |
14 |
1 |
2 |
||
4.98 |
1 Male |
286 |
290 |
301 |
4 |
11 |
2 Male |
311 |
310 |
321 |
-1 |
11 |
|
3 Male |
330 |
325 |
355 |
-5 |
30 |
|
4 Male |
326 |
333 |
350 |
7 |
17 |
|
5 Male |
323 |
322 |
350 |
-1 |
28 |
|
6 Female |
239 |
221 |
240 |
-18 |
19 |
|
7 Female |
259 |
248 |
255 |
-11 |
7 |
|
8 Female |
237 |
233 |
243 |
-4 |
10 |
|
9 Female |
222 |
233 |
226 |
11 |
-7 |
|
10 Female |
235 |
233 |
239 |
-2 |
6 |
Individual Necropsy Findings
Mean Achieved Atmosphere Concentration (mg/L) |
Macroscopic Observations |
Animal Number and Sex |
||||||||||
1 Male |
2 Male |
3 Male |
4 Male |
5 Male |
6 Female |
7 Female |
8 Female |
9 Female |
10 Female |
|||
4.98 |
Lungs: |
Dark Patches |
|
|
P |
|
|
|
|
|
|
|
|
|
N |
N |
|
N |
N |
N |
N |
N |
N |
N |
Endpoint conclusion
- Endpoint conclusion:
- no adverse effect observed
- Dose descriptor:
- LC50
- Value:
- 4.45 mg/m³ air
- Quality of whole database:
- The study used was a GLP guideline study.
Acute toxicity: via dermal route
Link to relevant study records
- Endpoint:
- acute toxicity: dermal
- Data waiving:
- study scientifically not necessary / other information available
- Justification for data waiving:
- other:
Reference
Additional information
Justification for selection of acute toxicity – oral endpoint
Lowest oral LD50 observed
Justification for selection of acute toxicity – inhalation endpoint
Only inhalation study available.
Justification for selection of acute toxicity – dermal endpoint
No study is available. Given the oral and dermal absorption
properties of the material however, it is not anticipated that the
dermal LD50 would be sufficiently low to warrant classification
Justification for classification or non-classification
MnCl2 needs to be classified for acute oral toxicity based on the weight of evidence from three studies indicated LD50s between 200 and 2000 mg/kg (IUCLID section 7.2.1., Kostial (1978), Vrcic (1998) and Singh (1991).
MnCl2 does not need to be classified for acute inhalation [based on readacross to MnSO4 which does not need to be classified for acute inhalation toxicity based on an LC50 > 4.98 mg/L (MnSO4 dossier; IUCLID section 7.2.2, Griffiths (2010)) for the monohydrate equating to LC50 > 4.45 for the anhydrous.Readacross to MnSO4 is considered scientifically acceptable based on both being very water soluble and common Mn2+ cation and low toxicity of anions, and unlike the oral route it is not likely that absorption would be controlled by the homeostatic mechanism, which probably explains the difference in the apparently greater acute oral toxicity of MnCl2 compared to MnSO4].
Classification for the acute dermal toxicity is not considered necessary as there is no significant dermal absorption seen in the in vitro dermal absorption study on MnCl2 (IUCLID section 7.1.2, Jaeger M (2010))
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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