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EC number: 816-285-7 | CAS number: 1263133-33-0
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Toxicity to birds
Administrative data
Link to relevant study record(s)
- Endpoint:
- short-term toxicity to birds: acute oral toxicity test
- Type of information:
- experimental study
- Adequacy of study:
- supporting study
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
- Qualifier:
- according to guideline
- Guideline:
- EPA OPPTS 850.2100 (Avian Acute Oral Toxicity Test)
- Deviations:
- no
- Qualifier:
- according to guideline
- Guideline:
- EPA OPP 71-1 (Avian Acute Oral Toxicity Test)
- Deviations:
- no
- GLP compliance:
- yes
- Dose method:
- capsule
- Analytical monitoring:
- no
- Vehicle:
- no
- Test organisms (species):
- Colinus virginianus
- Limit test:
- yes
- Remarks:
- single encapsulated dose
- Post exposure observation period:
- 14 days
- No. of animals per sex per dose and/or stage:
- 5
- Control animals:
- yes
- Nominal and measured doses / concentrations:
- 292, 486, 810, 1350, 2250 mg a.s./kg bw
- Reference substance (positive control):
- no
- Key result
- Dose descriptor:
- LD50
- Effect level:
- 2 109 mg/kg bw
- Conc. / dose based on:
- act. ingr.
- Basis for effect:
- mortality
- Key result
- Dose descriptor:
- NOEL
- Effect level:
- 292 mg/kg bw
- Conc. / dose based on:
- act. ingr.
- Basis for effect:
- body weight
- Validity criteria fulfilled:
- yes
- Conclusions:
- LD50 (Northern Bobwhite): 2109 mg a.s./kg bw (mortality)
NOEL (Northern Bobwhite): 292 mg a.s./kg bw (body weight) - Executive summary:
The test substance was administered to fasted northern bobwhite quail (Colinus virginianus) in an acute oral toxicity study. The study was conducted according to U.S. EPA OCSPP Number 850.2100 and FIFRA Subdivision E Section 71-1. Five bobwhite/sex/dose received single oral nominal doses of 0, 292, 486, 810, 1350 and 2250 mg a.s./kg body weight (bw) delivered in a capsule. Birds were observed for clinical signs of toxicity, body weight effects, and mortality for 14 days after dosing. Three birds from each dosage level were examined for gross pathological changes. The acute oral LD50 value for northern bobwhite exposed to the test substance by single oral dose was determined to be 2109 mg a.s./kg bw, with 95% confidence that it is greater than 1350 mg a.s./kg bw. The no mortality level was 1350 mg a.s./kg bw. The no-observed-effect level was 292 mg a.s./kg bw based on a body weight effect at the 486 mg a.s./kg bw dosage group.
- Endpoint:
- short-term toxicity to birds: acute oral toxicity test
- Type of information:
- experimental study
- Adequacy of study:
- supporting study
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 223 (Avian Acute Oral Toxicity Test)
- Deviations:
- no
- GLP compliance:
- yes
- Dose method:
- gavage
- Analytical monitoring:
- yes
- Vehicle:
- yes
- Remarks:
- 0.5 % (w/v) Sodium Carboxymethyl cellulose (medium viscosity) with 0.1% (v/v) Tween 80 in Milli-Q water
- Test organisms (species):
- Colomba livia
- Limit test:
- yes
- Remarks:
- single dose
- Post exposure observation period:
- 14 days
- No. of animals per sex per dose and/or stage:
- 5 (female)
- Control animals:
- yes, concurrent vehicle
- Nominal and measured doses / concentrations:
- 2000 mg a.i./kg body weight
- Reference substance (positive control):
- no
- Key result
- Dose descriptor:
- LD50
- Effect level:
- > 2 000 mg/kg bw
- Conc. / dose based on:
- act. ingr.
- Basis for effect:
- mortality
- Validity criteria fulfilled:
- yes
- Conclusions:
- LD50 (Pigeon): >2000 mg a.i./kg bw (mortality)
- Executive summary:
The acute oral toxicity study with the test substance in pigeon was conducted to assess the toxicological profile of the test item as per a limit dose test. The study was conducted according to OECD Guideline 223.
The test substance was administered as oral gavage to five overnight fasted (12 to 15 hours) female pigeons at the dose of 2000 mg a.i./kg body weight. The birds did not show any clinical signs of toxicity and there were no gross findings at necropsy. The birds decreased bodyweight on days 4 and gained body weight on days 8 and 15 when compared to their initial weight. Except one bird decreased body weight on days 4, 8 and 15 compared to their initial weight. The food consumption of the birds was comparable to the control group during days 1-4, 4-8 and 8-15.
The five birds of control group were administered 10 mL/kg body weight of the vehicle. There were no clinical signs of toxicity observed, food consumption was normal and weight of all birds increased throughout the observation period. There were no gross findings at necropsy.
Based on the above findings, the acute oral LD50 value for Pigeon exposed to the test substance as a single oral dose is determined to be greater than 2000 mg a.i./kg body weight.
- Endpoint:
- short-term toxicity to birds: acute oral toxicity test
- Type of information:
- experimental study
- Adequacy of study:
- supporting study
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 223 (Avian Acute Oral Toxicity Test)
- Deviations:
- no
- GLP compliance:
- yes
- Dose method:
- gavage
- Analytical monitoring:
- yes
- Vehicle:
- yes
- Remarks:
- 0.5% Sodium Caboxymethyl cellulose with 0.1% Tween 80 in Milli-Q-water
- Test organisms (species):
- other: Gallus gallus domesticus
- Limit test:
- yes
- Remarks:
- Single dose
- No. of animals per sex per dose and/or stage:
- 5
- Control animals:
- yes, concurrent vehicle
- Nominal and measured doses / concentrations:
- 2000 mg a.i./kg bw
- Reference substance (positive control):
- no
- Key result
- Dose descriptor:
- LD50
- Effect level:
- > 2 000 mg/kg bw
- Conc. / dose based on:
- act. ingr.
- Basis for effect:
- mortality
- Validity criteria fulfilled:
- yes
- Conclusions:
- LD50 (Chicken): >2000 mg a.i./kg bw (mortality)
- Executive summary:
The acute oral toxicity study with the test substance in Chicken was conducted to assess the toxicological profile of the test item as per the limit dose test. The study was conducted following OECD Guideline 223.
The test substance was administered as oral gavage to overnight fasted (12 to 15 hours) 5 female chicken at the dose of 2000 mg a.i./kg bw. The birds did not show any clinical signs of toxicity and there were no mortality or gross findings at necropsy. The birds had lost bodyweight on days 4, 8 and 15 when compared to their initial weight. The food consumption of the birds was lower during days 1-4, 4-8 and 8-15.
The five birds of control group were administered 10 mL/kg body weight of the vehicle. There were no clinical signs of toxicity observed; food consumption was normal and weight of all birds increased throughout the observation period. There were no gross findings at necropsy.
Based on the above findings, the acute oral LD50 value for Chicken exposed to the test substance as a single oral dose was determined to be greater than 2000 mg a.i./kg body weight.
- Endpoint:
- long-term toxicity to birds: reproduction test
- Type of information:
- experimental study
- Adequacy of study:
- supporting study
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 206 (Avian Reproduction Test)
- Deviations:
- no
- Qualifier:
- according to guideline
- Guideline:
- EPA OPPTS 850.2300 (Avian Reproduction Test)
- Deviations:
- no
- GLP compliance:
- yes
- Dose method:
- feed
- Analytical monitoring:
- yes
- Vehicle:
- yes
- Remarks:
- Laboratory diet
- Test organisms (species):
- Colinus virginianus
- Limit test:
- yes
- Total exposure duration (if not single dose):
- 21 wk
- Post exposure observation period:
- 6 weeks
- No. of animals per sex per dose and/or stage:
- 18 pairs of birds/group
- Control animals:
- yes
- Nominal and measured doses / concentrations:
- 0, 312.5, 625, and 1250 ppm a.s.
- Reference substance (positive control):
- no
- Key result
- Duration (if not single dose):
- 21 wk
- Dose descriptor:
- NOEC
- Effect level:
- 625 other: ppm
- Conc. / dose based on:
- act. ingr.
- Basis for effect:
- other: clinical observations and reproductive effects
- Remarks on result:
- other: equivalent to 50.7 mg a.s./kg bw/day
- Key result
- Duration (if not single dose):
- 21 wk
- Dose descriptor:
- LOEC
- Effect level:
- 1 250 other: ppm
- Conc. / dose based on:
- act. ingr.
- Basis for effect:
- other: clinical observations and reproductive effects
- Remarks on result:
- other: equivalent to 99.2 mg a.s./kg bw/day
- Validity criteria fulfilled:
- yes
- Conclusions:
- 21 weeks NOEC (Northern Bobwhite): 625 ppm a.s. (equivalent to 50.7 mg a.s./kg/day) (clinical observations and reproductive effects)
- Executive summary:
A one-generation northern bobwhite (Colinus virginianus) reproduction study was conducted with the test substance. The study was conducted according to OECD Guideline 206, U.S. EPA OCSPP 850.2300. Eighteen pairs of northern bobwhite received test substance in the feed at concentrations of 0, 312.5, 625, and 1250 ppm a.s. for 21 weeks. Reproductive parameters were measured beginning at the onset of egg laying. Adult birds were observed for abnormal behavior, mortality, signs of toxicity, and changes in body weight and food intake. All birds were examined for gross pathological changes.
There were no treatment-related mortalities or treatment-related effects upon body weight or feed consumption at any of the concentrations tested. In addition, there were no overt signs of toxicity and no treatment-related effects upon reproductive performance parameters measured at the 312.5 or 625 ppm a.s. test concentrations. However, at the 1250 ppm a.s. test concentration signs of toxicity were observed, as were slight reductions in viability, hatchability and offspring survival. The reductions in reproductive performance observed resulted in reductions in the number of hatchlings and 14-day old survivors of eggs set. A treatment related effect could not be precluded.
The NOEC for northern bobwhite exposed to the test substance in the diet for 21 weeks was 625 ppm a.s. (equivalent to 50.7 mg a.s./kg/day).
- Endpoint:
- short-term toxicity to birds: acute oral toxicity test
- Type of information:
- experimental study
- Adequacy of study:
- supporting study
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
- Qualifier:
- according to guideline
- Guideline:
- EPA OPPTS 850.2200 (Avian Dietary Toxicity Test)
- Deviations:
- no
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 205 (Avian Dietary Toxicity Test)
- Deviations:
- no
- GLP compliance:
- yes
- Dose method:
- feed
- Analytical monitoring:
- yes
- Vehicle:
- yes
- Remarks:
- Diet
- Test organisms (species):
- Colinus virginianus
- Limit test:
- yes
- Total exposure duration (if not single dose):
- 5 d
- Post exposure observation period:
- 3 days
- No. of animals per sex per dose and/or stage:
- Treatment group: 10 chicks
Control group: 30 chicks - Control animals:
- yes
- Nominal and measured doses / concentrations:
- 562, 1000, 1780, 3160 and 5620 ppm a.s.
- Reference substance (positive control):
- no
- Key result
- Dose descriptor:
- LC50
- Effect level:
- > 5 620 other: ppm
- Conc. / dose based on:
- act. ingr.
- Basis for effect:
- mortality
- Remarks on result:
- other: equivalent to 935 mg a.s./kg body weight/day, the highest concentration tested
- Key result
- Dose descriptor:
- NOEC
- Effect level:
- 1 000 other: ppm
- Conc. / dose based on:
- act. ingr.
- Basis for effect:
- body weight
- Remarks:
- body weight effect observed at the 1780 ppm a.s. (379 mg a.s./kg bw/day)
- Remarks on result:
- other: equivalent to 189 mg a.s./kg bw/day
- Validity criteria fulfilled:
- yes
- Conclusions:
- LC50 (Northern Bobwhite): >5620 ppm a.s. (935 mg a.s./kg bw/day) (mortality) (highest concentration tested)
NOEC (Northern Bobwhite): 1000 ppm a.s. (189 mg a.s./kg bw/day) (body weight) - Executive summary:
The test substance was administered to juvenile northern bobwhite quail (Colinus virginianus) in a dietary LC50 study. The study was conducted according to the U.S. EPA OCSPP Number 850.2200 and OECD Guideline 205.
Thirty northern bobwhite chicks (five per pen) were assigned to the control group and ten northern bobwhite chicks (five per pen) were assigned to each of the treatment groups 562, 1000, 1780, 3160 and 5620 parts per million of active substance of the test substance (ppm a.s.). Birds were observed for clinical signs of toxicity, body weight effects, and mortality for 8 days. Since there were no treatment related mortalities or signs of toxicity, only three birds from each test concentration were examined for gross pathological changes. The LC50 value for northern bobwhite exposed to the test substance in diet was >5620 ppm a.s. (equivalent to 935 mg a.s./kg body weight/day), the highest concentration tested. The no mortality concentration was 5620 ppm a.s. and the no-observed effect concentration was 1000 ppm a.s.
- Endpoint:
- long-term toxicity to birds: reproduction test
- Type of information:
- experimental study
- Adequacy of study:
- supporting study
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
- Qualifier:
- according to guideline
- Guideline:
- EPA OPP 71-4 (Avian Reproduction Test)
- Deviations:
- no
- Qualifier:
- according to guideline
- Guideline:
- EPA OPPTS 850.2300 (Avian Reproduction Test)
- Deviations:
- no
- Qualifier:
- according to guideline
- Guideline:
- other: ASTM Standard E1062-86
- Deviations:
- no
- GLP compliance:
- no
- Dose method:
- feed
- Analytical monitoring:
- yes
- Vehicle:
- yes
- Remarks:
- Diet
- Test organisms (species):
- Colinus virginianus
- Limit test:
- yes
- Total exposure duration (if not single dose):
- 6 wk
- No. of animals per sex per dose and/or stage:
- 5
- Control animals:
- yes
- Nominal and measured doses / concentrations:
- 200, 1000 and 5000 ppm a.s.
- Reference substance (positive control):
- no
- Key result
- Duration (if not single dose):
- 6 wk
- Remarks on result:
- other: There were no treatment-related mortalities or overt signs of toxicity at any concentration tested. There were no treatment-related effects upon body weight or feed consumption at the 200 or 1000 ppm a.s. test concentrations.
- Key result
- Duration (if not single dose):
- 6 wk
- Remarks on result:
- other: While there was no impact upon egg production at the 200 ppm a.s. test concentration, there may have been a slight delay in the onset of egg production at the 1000 ppm a.s. test concentration.
- Remarks:
- At the 5000 ppm a.s. test concentration there was a transient, treatment-related effect upon body weight and feed consumption and a marked, treatment-related effect on egg production.
- Validity criteria fulfilled:
- yes
- Conclusions:
- There were no treatment-related mortalities or overt signs of toxicity at any concentration tested. While there was no impact upon egg production at the 200 ppm a.s. test concentration, there may have been a slight delay in the onset of egg production at the 1000 ppm a.s. test concentration. At the 5000 ppm a.s. test concentration there was a transient, treatment-related effect upon body weight and feed consumption and a marked, treatment-related effect on egg production.
- Executive summary:
The objective of this study was to evaluate the effects upon adult northern bobwhite of dietary exposure to the test substance over a six-week period. The study was conducted following guidelines U.S. EPA OPPTS Number 850.2300, FIFRA Subdivision E Section 71-4, ASTM Standard E1062-86.
Northern bobwhites were exposed to the test substance at dietary concentrations of 0, 200, 1000 and 5000 ppm a.s. There were no treatment-related mortalities or overt signs of toxicity at any concentration tested. There were no treatment-related effects upon body weight or feed consumption at the 200 or 1000 ppm a.s. test concentrations. While there was no impact upon egg production at the 200 ppm a.s. test concentration, there may have been a slight delay in the onset of egg production at the 1000 ppm a.s. test concentration. At the 5000 ppm a.s. test concentration there was a transient, treatment-related effect upon body weight and feed consumption and a marked, treatment-related effect on egg production. While the control group averaged 0.52 eggs/hen/day, the hens in the 5000 ppm a.s. treatment group produced only 0.13 eggs/hen/day.
- Endpoint:
- short-term toxicity to birds: acute oral toxicity test
- Type of information:
- experimental study
- Adequacy of study:
- supporting study
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 205 (Avian Dietary Toxicity Test)
- Deviations:
- no
- GLP compliance:
- yes
- Dose method:
- feed
- Analytical monitoring:
- yes
- Vehicle:
- yes
- Remarks:
- diet
- Test organisms (species):
- Coturnix coturnix japonica
- Limit test:
- yes
- Total exposure duration (if not single dose):
- 5 d
- Post exposure observation period:
- 3 days
- No. of animals per sex per dose and/or stage:
- 10
- Control animals:
- yes, plain diet
- Nominal and measured doses / concentrations:
- 5000 ppm
- Reference substance (positive control):
- no
- Key result
- Duration (if not single dose):
- 5 d
- Dose descriptor:
- other: minimum lethal concentration
- Effect level:
- > 5 000 other: ppm
- Conc. / dose based on:
- test mat.
- Basis for effect:
- mortality
- Remarks on result:
- other: equivalent to 957.67 mg/kg body weight, highest dose tested
- Validity criteria fulfilled:
- yes
- Conclusions:
- Minimum lethal concentration (Japanese quails): >5000 ppm (equivalent to 957.67 mg/kg bw)
- Executive summary:
The avian dietary toxicity study with the test substance on Japanese Quails was conducted to assess the toxicological profile of the test substance on repeated exposure to avian species, following OECD Guideline 205.
The study was conducted with 2 control groups and 1 treatment group (limit dose) at the dose of 5000 ppm. The test substance was mixed with feed at the dose of 5000 ppm in diet and fed to quails for 5 days followed by normal feed for 3 days and concurrent control groups were also maintained.
In the treatment group, body weight was lower on days 6 and 9 when compared to the control group. Feed consumption was lower during days 1-6 (treatment period) and was comparable to the control groups during days 6-9 (when fed normal feed). There were no mortality or gross findings at necropsy.
Based on the above results, the acute dietary minimum lethal concentration of the test substance in Japanese quails was greater than 5000 ppm of diet, which was equivalent to 957.67 mg/kg body weight.
Referenceopen allclose all
Description of key information
5-day LC50 (Northern Bobwhite) > 5620 ppm a.s. (935 mg a.s./kg/day); OECD 205; Reliability = 1
5-day NOEC (Northern Bobwhite) = 1000 ppm a.s. (189 mg a.s./kg/day); OECD 205; Reliability = 1
14-day LD50 (Northern Bobwhite) = 2109 mg a.s./kg; OPPTS 850.2100; Reliability = 1
14-day NOEL (Northern Bobwhite) = 292 mg a.s./kg; OPPTS 850.2100; Reliability = 1
6-week LOEC (Northern Bobwhite) = 1000 ppm a.s.; OPPTS 850.2300; Reliability = 1
21-week NOEC (Northern Bobwhite) = 625 ppm a.s. (50.7 mg a.s./kg/day); OECD 206; Reliability = 1
14-day LD50 (Pigeon) > 2000 mg a.i./kg: OECD 223; Reliability = 1
9-day Minimum lethal concentration (Japanese quails) >5000 ppm (957.67 mg/kg); OECD 205; Reliability = 1
15-day LD50 (Chicken) > 2000 mg a.i./kg; OECD 223; Reliability = 1
Key value for chemical safety assessment
- Short-term EC50 or LC50 for birds:
- 935 mg/kg food
- Long-term EC10, LC10 or NOEC for birds:
- 50.7 mg/kg food
Additional information
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.