Registration Dossier
Registration Dossier
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EC number: 229-542-8 | CAS number: 6600-31-3
Acute Toxicity: oral
Administrative data
- Endpoint:
- acute toxicity: oral
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: scientifically acceptable and sufficient documented
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 976
- Report date:
- 1976
Materials and methods
- Principles of method if other than guideline:
- Ten male rats received a single dose (2500 or 5000 mg/kg bw) per gavage. The animals were observed for mortality, body weight gain and clinical signs through day 14.
- GLP compliance:
- no
- Test type:
- standard acute method
Test material
- Reference substance name:
- 3,9-dicyclohex-3-enyl-2,4,8,10-tetraoxaspiro[5.5]undecane
- EC Number:
- 229-542-8
- EC Name:
- 3,9-dicyclohex-3-enyl-2,4,8,10-tetraoxaspiro[5.5]undecane
- Cas Number:
- 6600-31-3
- Molecular formula:
- C19H28O4
- IUPAC Name:
- 3,9-bis(cyclohex-3-en-1-yl)-2,4,8,10-tetraoxaspiro[5.5]undecane
- Details on test material:
- KAC 4196 = 3,9-dicyclohex-3-enyl-2,4,8,10-tetraoxaspiro[5.5]undecane, chemical pure product
Constituent 1
Test animals
- Species:
- rat
- Strain:
- Wistar
- Sex:
- male
Administration / exposure
- Route of administration:
- oral: gavage
- Vehicle:
- other: Lutrol
- Doses:
- 2500 or 5000 mg/kg bw
- No. of animals per sex per dose:
- 10 male rats per dose
- Control animals:
- not specified
Results and discussion
Effect levels
- Sex:
- male
- Dose descriptor:
- LD50
- Effect level:
- > 5 000 mg/kg bw
- Based on:
- test mat.
Any other information on results incl. tables
None of the animals which received a dose of 2500 mg/kg bw died and no clinicla signs were observed. One animal our of 10 died which received a dose of 5000 mg/kg bw. The animal died after 2 days. No clinicla signs were observed on the animals which survived.
Signs of intoxication were sedation and a decrease of the general condition.
Applicant's summary and conclusion
- Interpretation of results:
- relatively harmless
- Remarks:
- Migrated information
- Executive summary:
Ten male rats received a single dose (2500 or 5000 mg/kg bw) per gavage. The animals were observed for mortality, body weight gain and clinical signs through day 14.
None of the animals which received a dose of 2500 mg/kg bw died and no clinicla signs were observed. One animal our of 10 died which received a dose of 5000 mg/kg bw. The animal died after 2 days. No clinicla signs were observed on the animals which survived.
Signs of intoxication were sedation and a decrease of the general condition.
The LD50 is > 5000 mg(kg bw (male rats)
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