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Diss Factsheets
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EC number: 451-000-6 | CAS number: -
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Skin sensitisation
Administrative data
- Endpoint:
- skin sensitisation: in vivo (LLNA)
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 1 (reliable without restriction)
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 2 004
- Report date:
- 2004
Materials and methods
Test guidelineopen allclose all
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 429 (Skin Sensitisation: Local Lymph Node Assay)
- Qualifier:
- according to guideline
- Guideline:
- EU Method B.42 (Skin Sensitisation: Local Lymph Node Assay)
- Version / remarks:
- draft dd. 2001
- Qualifier:
- according to guideline
- Guideline:
- EPA OPPTS 870.2600 (Skin Sensitisation)
- Version / remarks:
- dd. 2003
- GLP compliance:
- yes (incl. QA statement)
- Type of study:
- mouse local lymph node assay (LLNA)
Test material
- Reference substance name:
- benzene, 1,4-bis[2-[3,5-dimethoxy-4-(1- methylpropoxy)phenyl]ethenyl]-
- Cas Number:
- 586410-55-1
- Molecular formula:
- C34 H42 O6
- IUPAC Name:
- benzene, 1,4-bis[2-[3,5-dimethoxy-4-(1- methylpropoxy)phenyl]ethenyl]-
- Details on test material:
- Read-across from CASRN586410-55-1 to the substance defined in section 1 allowed by belgian authority.
Constituent 1
In vivo test system
Test animals
- Species:
- mouse
- Strain:
- CBA
- Sex:
- female
- Details on test animals and environmental conditions:
- nulliparous and non-pregnant, young adult animals (+/-10 weeks old; body weight variation +/- 20% of the sex mean)
Study design: in vivo (LLNA)
- Vehicle:
- propylene glycol
- Concentration:
- 5%, 25% and 50%
- No. of animals per dose:
- 5
- Details on study design:
- A preliminary irritation study was conducted in order to select the highest test substance concnetration to be used in the amin study. Starting- and subsequent concentrations for this preliminary study were taken from the series: 100% (undiluted), 50%, 25%, 10%, 5%, 2.5%, 1% and further lower cocnetrations using the same steps.
In the main study, the observation was as follows:
1. mortality/viability: twice daily
2. toxicity: at least once daily
3. body weights: on day 1 (pre-treatment) and 6
4. irritation: on day 3 (3-4 hours after treatment), the skin reactions were assessed - Positive control substance(s):
- hexyl cinnamic aldehyde (CAS No 101-86-0)
Results and discussion
- Positive control results:
- The calculated EC3 value was found to be in the acceptable range of 2 and 20%.
In vivo (LLNA)
Resultsopen allclose all
- Parameter:
- SI
- Remarks on result:
- other: Main study: The SI values calculated for the substance concentrations 4, 25 and 50% were 1.0, 0.7 and 0.9 respectively. There was no indication that the test substance could elicit an SI>=3.
- Parameter:
- other: disintegrations per minute (DPM)
- Remarks on result:
- other: Main study: Mean DPM/animal values for the experimental groups treated with test substance concentrations 5, 25 and 50% were 180, 114 and 160 respectively. The mean DPM/animal value for the vehicle conctrol group was 173.
Any other information on results incl. tables
1. preliminary study: no irritation was observed in any of the animals examined. based on the results, the highest test substance concentration for the main study was a 50% concentration.
2. main study:
2.1. induction phase: no irritation was observed in any of the animals examined
2.2. macroscopy: the majority of nodes were equal in size, except for some nodes of the 25 and 50% groups that were smaller in size. no other macroscopic abnormalities of the nodes were noted.
2.3. body weights: body weights and body weight gain of experimental animals remained in the same range as controls over the study period. The slight body weight loss, noted in some animals, was considered not toxicologically significant.
2.4. toxicity/mortality: no mortality occurred and no symptoms of systemic toxicity were observed in the animals of the main study.
Applicant's summary and conclusion
- Interpretation of results:
- not sensitising
- Remarks:
- Migrated information
- Conclusions:
- not classified for sensitisation by skin contact (according to OECD (1998) and EU (67/548/EEC))
no obligatory labelling requirement for sensitisation by skin contact (EU (67/548/EEC))
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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