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EC number: 414-780-9 | CAS number: 38585-74-9 A-87440.0; A-87440.00
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Eye irritation
Administrative data
- Endpoint:
- eye irritation: in vivo
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 11 April - 31 August, 1994
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- other: Study was conducted according to OECD and in accordance with GLP. The study material is well characterized
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 994
- Report date:
- 1994
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- EU Method B.5 (Acute Toxicity: Eye Irritation / Corrosion)
- Version / remarks:
- 92/69/EEC
- GLP compliance:
- yes
Test material
- Reference substance name:
- 5-thiazolylmethanol
- EC Number:
- 414-780-9
- EC Name:
- 5-thiazolylmethanol
- Cas Number:
- 38585-74-9
- Molecular formula:
- C4H5NOS
- IUPAC Name:
- (1,3-thiazol-5-yl)methanol
Constituent 1
Test animals / tissue source
- Species:
- rabbit
- Strain:
- New Zealand White
- Details on test animals or tissues and environmental conditions:
- Seven male rabbits from Charles River, Montreal weighing 2- 3 kg (10 to 15 weeks) on arrival were allowed to acclimatise for 13 days before treatment. 6 animals were assigned to the study. 100 -130g Certified High Fibre Rabbit Chow was provided each day and water ad libitum. The temperature was maintained at 64 - 68°F. The animal room was on a 12 hour daily light cycle.
Test system
- Vehicle:
- unchanged (no vehicle)
- Controls:
- other: other: right eye of each animal was untreated
- Amount / concentration applied:
- 0.1ml
- Duration of treatment / exposure:
- 0.1ml test material was placed in the conjunctival sac of the left eye and gently pulling the lower eye lid away from the eyeball. The upper and lower eyelid were held closed for about one second after treatment to prevent loose of material and then released. The right eye was left untreated to serve as the control.
- Observation period (in vivo):
- After the 24hr observation period the eyesof all rabbits were washed with lukewarm water.
All animals were observed daily for signs of ill health or toxicity. - Number of animals or in vitro replicates:
- 6 male rabbits
- Details on study design:
- On the day prior to treatment the eyes were checked by a veterinarian.
Results and discussion
In vivo
Resultsopen allclose all
- Irritation parameter:
- cornea opacity score
- Basis:
- mean
- Time point:
- other: 1,24, 48,72 hours and day 4,7,14,21
- Score:
- 0.8
- Max. score:
- 1
- Reversibility:
- fully reversible within: day 21
- Irritation parameter:
- iris score
- Basis:
- mean
- Time point:
- other: 1,24, 48,72 hours and day 4,7,14,21
- Score:
- 0
- Max. score:
- 0
- Reversibility:
- fully reversible
- Irritation parameter:
- chemosis score
- Basis:
- mean
- Time point:
- other: 1,24, 48,72 hours and day 4,7,14,21
- Score:
- 3
- Max. score:
- 4
- Reversibility:
- not fully reversible within: 21 days
- Remarks on result:
- other: value at end of observation period 2
- Irritation parameter:
- conjunctivae score
- Remarks:
- redness
- Basis:
- mean
- Time point:
- other: 1, 24, 48, 72 hours and day 4, 7, 14, 21
- Score:
- 1.6
- Max. score:
- 3
- Reversibility:
- not fully reversible within: day 21
- Remarks on result:
- other: value at end of observation period 2
- Other effects:
- Scattered or difuse areas of corneal capacity were observed in all six rabbits. However, the corneal opacity was reversible in all rabbits on or before day 21.
Severe chemosis and discharge were noted in the eyes in all rabbits by one hour of instillation of the test material. Also, various degrees of conjunctival redness were observed in the treated eyes of rabbits during the observation period following treatment. Complete recovery of the treated eye from occular irritation was observed in two rabbits by day 7, in a third rabbit by day 14 and in a forth rabbit by day 21. In the remaining two rabbits, some mild occular irritation persisted in the treated eye on the day of the final observation (day 21).
Applicant's summary and conclusion
- Interpretation of results:
- irritating
- Remarks:
- Migrated information Criteria used for interpretation of results: EU
- Conclusions:
- Abbott-87440 was found to be irritating to the eyes of rabbits in this study.
- Executive summary:
Scattered or difuse areas of corneal capacity were observed in all six rabbits. However, the corneal opacity was reversible in all rabbits on or before day 21.
Severe chemosis and discharge were noted in the eyes in all rabbits by one hour of instillation of the test material. Also, various degrees of conjunctival redness were observed in the treated eyes of rabbits during the observation period following treatment. Complete recovery of the treated eye from occular irritation was observed in two rabbits by day 7, in a third rabbit by day 14 and in a forth rabbit by day 21. In the remaining two rabbits, some mild occular irritation persisted in the treated eye on the day of the final observation (day 21).
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