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EC number: 801-277-8 | CAS number: 507448-65-9
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Acute Toxicity: oral
Administrative data
- Endpoint:
- acute toxicity: oral
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 1 (reliable without restriction)
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 999
- Report date:
- 1999
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 423 (Acute Oral toxicity - Acute Toxic Class Method)
- Deviations:
- no
- GLP compliance:
- yes (incl. QA statement)
- Test type:
- acute toxic class method
Test material
- Reference substance name:
- ethyl (2Z)-4,4,4-trifluoro-3-(methylamino)but-2-enoate
- EC Number:
- 801-277-8
- Cas Number:
- 507448-65-9
- Molecular formula:
- C7H10F3NO2
- IUPAC Name:
- ethyl (2Z)-4,4,4-trifluoro-3-(methylamino)but-2-enoate
Constituent 1
Test animals
- Species:
- rat
- Strain:
- Wistar
- Sex:
- male/female
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
- Source: BRL Biological Research Laboratories, Wölferstrasse 4, 4414 Füllinsdorf / Switzerland
- Age at study initiation: Young adult (approximately 7 -11 weeks)
- Weight at study initiation: 173 - 225 g
- Fasting period before study: fasted overnight prior to dosing
- Housing: 3 same-sex animals per cage
- Diet : ad libitum:
- Water: ad libitum
- Acclimation period: 5 days
ENVIRONMENTAL CONDITIONS
- Temperature (°C): 22 °C ± 3 °C
- Humidity (%): 50 % ± 20 %
- Air changes (per hr): 13 - 14
- Photoperiod (hrs dark / hrs light): 12/12
IN-LIFE DATES:
Date of termination of in-life phase: 200 mg/kg - January 27, 1999 (females)
2000 mg/kg - February 2, 1999 (females)
2000 mg/kg - February 5, 1999 (males)
Administration / exposure
- Route of administration:
- oral: gavage
- Vehicle:
- CMC (carboxymethyl cellulose)
- Remarks:
- 0.5 % (w/v) in 0.1 % (w/v) aqueous polysorbate 80
- Details on oral exposure:
- VEHICLE
- Concentration in vehicle: 200 mg/kg (females), 2000 mg/kg (both sexes)
200 mg/kg: 203 mg test article with vehicle ad 10 ml
2000 mg/kg: 2007 mg test article with vehicle ad 10 ml
2000 mg/kg: 2006 mg test article with vehicle ad 10 ml
- Volume applied: 10 ml/kg
DOSAGE
- Frequency of administration: One single dose - Doses:
- One single dose
- No. of animals per sex per dose:
- 3
- Control animals:
- no
- Details on study design:
- - Period of observation: 14 days
- Clinical observations: Checked and recorded individually at 1, 3 and 5 hours after dosing, then daily for the duration of the
observation period.
- Mortality: Checked twice daily, morning and afternoon.
- Body weight: Measured and recorded immediately before dose administration, then on days 7 and 14.
- Necropsy of survivors performed: Yes. If animals were found dead or sacrificed in extremis, they were necropsied as soon as possible.
Results and discussion
Effect levels
- Sex:
- male/female
- Dose descriptor:
- LD50
- Effect level:
- > 2 000 mg/kg bw
- Based on:
- test mat.
- Mortality:
- One male in the 2000 mg/kg group was found dead 4 days after treatment and one female in the 2000 mg/kg group was found dead 1 day after treatment.
- Clinical signs:
- other: There were no in-life observations indicating treatment related systemic effects for any animal in the 200 mg/kg group. Ventral recumbency was seen in all animals in the 2000 mg/kg groups on the treatment day. Hypoactivity of various intensity was seen
- Gross pathology:
- Necropsy examinations revealed no observable abnormalities.
Applicant's summary and conclusion
- Interpretation of results:
- study cannot be used for classification
- Remarks:
- Migrated information
- Conclusions:
- The following acute oral LD50 values were determined for CA 2455 A Intermediate of CGA 276854):
LD50 in male rats: Greater than 2000 mg/kg body weight
LD50 in female rats: Greater than 2000 mg/kg body weight
LD50 in rats of both sexes: Greater than 2000 mg/kg body weight - Executive summary:
Groups of 3 male and 3 female rats were administered a single dose of CA 2455 A (Intermediate CGA 276854) (batch no. LOT 3) by gavage at a dose levels of 200 mg/kg (females) and 2000 mg/kg (both sexes), followed by a 14 day post-treatment observation period.
One male in the 2000 mg/kg group was found dead 4 days after treatment and one female in the 2000 mg/kg group was found dead 1 day after treatment.
There were no in-life observations indicating treatment related systemic effects for any animal in the 200 mg/kg group. Ventral recumbency was seen in all animals in the 2000 mg/kg groups on the treatment day. Hypoactivity of various intensity was seen in all animals in the 2000 mg/kg groups on the treatment day and in all males in the 2000 mg/kg group on day 1 and 2 after treatment. Slight to moderate piloerection was seen in all males in the 2000 mg/kg group on the treatment day through day 3 after treatment and in two males through day 4 after treatment, slight piloerection was seen in 2 females in the 2000 mg/kg group on the treatment day and on day 3 after treatment in 2 males also on day 4 after treatment, and in two females in the 2000 mg/kg group on day 1 after treatment. All surviving males in the 2000 mg/kg group appeared normal by day 5 after treatment, all surviving females in the 2000 mg/kg group appeared normal by day 2 after treatment.
Body weights were not affected by the treatment.
Necropsy examinations revealed no observable abnormalities.
The following acute oral LD50 values were determined for CA 2455 A Intermediate of CGA 276854):
LD50in male rats: Greater than 2000 mg/kg body weight
LD50in female rats: Greater than 2000 mg/kg body weight
LD50in rats of both sexes: Greater than 2000 mg/kg body weight
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