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Diss Factsheets
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EC number: 910-704-8 | CAS number: -
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Developmental toxicity / teratogenicity
Administrative data
- Endpoint:
- developmental toxicity
- Type of information:
- migrated information: read-across from supporting substance (structural analogue or surrogate)
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 974
- Report date:
- 1974
Materials and methods
Test guideline
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- OECD Guideline 414 (Prenatal Developmental Toxicity Study)
- GLP compliance:
- no
- Limit test:
- no
Test material
- Reference substance name:
- Calcium oxide
- EC Number:
- 215-138-9
- EC Name:
- Calcium oxide
- Cas Number:
- 1305-78-8
- IUPAC Name:
- oxocalcium
- Details on test material:
- - Name of test material (as cited in study report): FDA 73-41 (calcium oxide)
- Physical state: solid
No further details are given.
Constituent 1
Test animals
- Species:
- rat
- Strain:
- Wistar
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
- Housing: Rats were housed individually in mesh bottom cages.
- Diet: ad libitum
- Water: ad libitum; tap water
ENVIRONMENTAL CONDITIONS
- Temperature (°C): 23 - 27
- Humidity (%): 64 - 78
No further details are given.
Administration / exposure
- Route of administration:
- oral: gavage
- Vehicle:
- water
- Details on exposure:
- no detailed data given
- Analytical verification of doses or concentrations:
- not specified
- Details on analytical verification of doses or concentrations:
- no detailed data given
- Details on mating procedure:
- The female rats were mated with young adult males.
- Impregnation procedure: cohoused
- If cohoused:
- M/F ratio per cage: 1/1; one male was not permitted to impregnate more than one female per group.
- Length of cohabitation: no data
- Proof of pregnancy: vaginal plug referred to as day 0 of pregnancy
No further details are given. - Duration of treatment / exposure:
- Beginning on day 6 and continuing through day 15 of gestation, the females were dosed with the indicated dosages.
- Frequency of treatment:
- Once daily
- Duration of test:
- Until day 20 of pregnancy
Doses / concentrationsopen allclose all
- Remarks:
- Doses / Concentrations:
6.8 mg/kg
Basis:
nominal in water
- Remarks:
- Doses / Concentrations:
31.5 mg/kg
Basis:
nominal in water
- Remarks:
- Doses / Concentrations:
146.5 mg/kg
Basis:
nominal in water
- Remarks:
- Doses / Concentrations:
680 mg/kg
Basis:
nominal in water
- No. of animals per sex per dose:
- mated: 21 to 22 rats
pregnant: 19 to 20 rats - Control animals:
- yes
- yes, sham-exposed
Examinations
- Maternal examinations:
- CAGE SIDE OBSERVATIONS: Yes
- Time schedule: daily
DETAILED CLINICAL OBSERVATIONS: Yes
- Time schedule: All animals were observed daily for appearance and behaviour.
BODY WEIGHT: Yes
- Time schedule for examinations: Average body weight was determined on days 0, 6, 11, 15 and 20 of gestation.
FOOD CONSUMPTION AND COMPOUND INTAKE (if feeding study): Yes; however, compound intake occurred via gavave.
- Time schedule: All animals were observed daily with particular attention to food consumption and weight.
WATER CONSUMPTION AND COMPOUND INTAKE (if drinking water study): No data; not applicable
POST-MORTEM EXAMINATIONS: Yes
- Sacrifice on gestation day 20
- Organs examined: The urogential tract of each dam was examined in detail for anatomical normality. - Ovaries and uterine content:
- The ovaries and uterine content was examined after termination: Yes
Examinations included:
- Gravid uterus weight: No data
- Number of corpora lutea: Yes
- Number of implantations: Yes
- Number of early resorptions: Yes
- Number of late resorptions: Yes - Fetal examinations:
- - External examinations: Yes
- Soft tissue examinations: Yes
- Skeletal examinations: Yes
- Head examinations: Yes - Statistics:
- no data given
- Indices:
- no data given
- Historical control data:
- no data given
Results and discussion
Results: maternal animals
Maternal developmental toxicity
- Details on maternal toxic effects:
- Maternal toxic effects:no effects
Details on maternal toxic effects:
Administration of up to 680 mg/kg bw/d of CaO to pregnant rats for 10 consecutive days had no clearly discernible effect on maternal survival.
Effect levels (maternal animals)
- Dose descriptor:
- NOAEL
- Effect level:
- 680 mg/kg bw/day
- Basis for effect level:
- other: developmental toxicity
Results (fetuses)
- Details on embryotoxic / teratogenic effects:
- Embryotoxic / teratogenic effects:no effects
Details on embryotoxic / teratogenic effects:
Administration of up to 680 mg/kg bw/d of CaO to pregnant rats for 10 consecutive days had no clearly discernible effect on foetal survival. The number of abnormalities seen in either soft or skeletal tissues of test groups did not differ from the number occuring sponaneously in sham-treated controls.
Fetal abnormalities
- Abnormalities:
- not specified
Overall developmental toxicity
- Developmental effects observed:
- not specified
Applicant's summary and conclusion
- Conclusions:
- Administration of up to 680 mg/kg (body weight) of the test material to pregnant rats for 10 consecutive days had no clearly discernible effect on nidation or on maternal or foetal survival. The number of abnormalities seen in either soft or skeletal tissues of test groups did not differ from the number occuring spontaneously in sham-treated controls.
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