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Diss Factsheets
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EC number: 700-518-3 | CAS number: 38233-76-0
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Endpoint summary
Administrative data
Key value for chemical safety assessment
Effects on fertility
Effect on fertility: via oral route
- Dose descriptor:
- NOAEL
- 50 mg/kg bw/day
Additional information
A screening study (Huntingdon Life Sciences, 2011, study number VHJ0023) was conducted to assess the reproductive and developmental toxicity of ETD in Rats (Wistar). The study was conducted according to OECD test guideline 421, and in compliance with GLP.
Groups of 10 animals per sex per dose level were administered dose levels 0 (vehicle control), 12.5, 50, and 200 mg/kg/day by oral gavage. Males were administered test item for six consecutive weeks; females were administered test item for 15 days before pairing until day 6 after the birth of the F1 generation.
A minor change in the oestrous cycles was seen at 200 mg/kg/day, as well as a significantly low number of implantations and reduced litter size. Minimal effects were seen at 50 mg/kg/day, and on this basis it was concluded that the NOAEL was 50 mg/kg/day for reproductive performance when ETD was administered to the Wistar rat.
Short description of key information:
NOAEL (Screening study in Rats, Oral gavage) = 50 mg/kg/day
Justification for classification or non-classification
Effects on fertility (changes to the oestrous cycle, and a reduced number of implantations) were seen at high doses in the screening study noted above. A full study (for example an OECD 414 Guideline study) is not available for reproductive or developmental toxicity, and so the result is not considered entirely conclusive. On this basis, ETD is classified as a Category 2 reproductive toxin according to the CLP Regulation (Regulation (EC) 1272/2008); the applicable Hazard phrase is therefore "H361: Suspected of damaging fertility or the unborn child".
The corresponding classification according to the Dangerous Substances Directive (67/548/EEC) is "Reproductive Category 3, R62: Possible risk of impaired fertility".
Additional information
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.