Registration Dossier
Registration Dossier
Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.
The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 938-094-9 | CAS number: -
Toxicity to reproduction
Administrative data
- Endpoint:
- one-generation reproductive toxicity
- Remarks:
- based on test type (migrated information)
- Type of information:
- experimental study
- Adequacy of study:
- weight of evidence
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Referred in a recognized source of peer reviewed scientific data on chemicals
Data source
Reference
- Reference Type:
- publication
- Title:
- A re-examination of the possible teratogenic effects of butylated hydroxytoluene (BHT) and its effect on the reproductive capacity of the mouse.
- Author:
- Johnson
- Year:
- 1 965
- Bibliographic source:
- Food Cosmet Toxicol. 1965 Sep; 3(3): 371-375.
Materials and methods
Test guideline
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- OECD Guideline 415 [One-Generation Reproduction Toxicity Study (before 9 October 2017)]
- GLP compliance:
- not specified
Test material
- Reference substance name:
- 2,6-di-tert-butyl-p-cresol
- EC Number:
- 204-881-4
- EC Name:
- 2,6-di-tert-butyl-p-cresol
- Cas Number:
- 128-37-0
- Molecular formula:
- C15H24O
- IUPAC Name:
- Phenol, 2,6-bis(1,1-dimethylethyl)-4-methyl-
- Details on test material:
- data for components
Constituent 1
Results and discussion
Overall reproductive toxicity
- Reproductive effects observed:
- not specified
Any other information on results incl. tables
Study observed:
At 0.5%: no anophthalmia was observed in F1 generation; some effects on reproductive function
The study authors concluded that under the conditions of the experiment and in the strains of mice employed, BHT was not a teratogenic agent.
NOAEL (reproductive) =143 mg/kg bw/day
Applicant's summary and conclusion
- Conclusions:
- Data on component
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
