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EC number: 269-822-7 | CAS number: 68334-30-5 A complex combination of hydrocarbons produced by the distillation of crude oil. It consists of hydrocarbons having carbon numbers predominantly in the range of C9 through C20 and boiling in the range of approximately 163°C to 357°C (325°F to 675°F).
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Developmental toxicity / teratogenicity
Administrative data
- Endpoint:
- developmental toxicity
- Type of information:
- migrated information: read-across from supporting substance (structural analogue or surrogate)
- Adequacy of study:
- key study
- Study period:
- 1979
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: The study was subjected to a Quality Assurance inspection but there is no information regarding compliance with GLP requirements. Nevertheless the study was well conducted and reported and is considered reliable.
Cross-reference
- Reason / purpose for cross-reference:
- reference to same study
Data source
Reference
- Reference Type:
- review article or handbook
- Title:
- ROBUST SUMMARY OF NFORMATION ON Distillate Fuels
- Author:
- American Petroleum Institute
- Year:
- 2 003
- Bibliographic source:
- ROBUST SUMMARY OF NFORMATION ON Distillate Fuels pag 58-60
Materials and methods
Test guideline
- Qualifier:
- no guideline available
- Deviations:
- not specified
- Principles of method if other than guideline:
- The API procedure is defined in: Any other information on materials and Methods
- GLP compliance:
- not specified
Test material
- Reference substance name:
- No.2-DA
- IUPAC Name:
- No.2-DA
- Details on test material:
- Boiling range (ASTM D-56) : 372-656° F
Flash point (ASTM D-56) : 136° F
Wt. Sulphur %: 0.1
Viscosity @ 100° F (ASTM D-445): 2.4 cSt
Hydrocarbon types identified by mass spectrometry were:
Paraffins : 42.7 Wt. %
Cycloparaffins 33.4 Wt %
Monocycloparaffins 23.4
Dicycloparaffins 8.0
Tricycloparaffins 2.0
Aromatics 23.9 Wt. %
Alkylbenzenes 9.7
Indans & tetralins 4.8
Dinaphthenobenzenes 1.3
Biphenyls etc. 1.3
Fluorenes etc. 0.7
Tricyclic aromatics 0.8
Constituent 1
Test animals
- Species:
- rat
Administration / exposure
- Route of administration:
- inhalation
- Type of inhalation exposure (if applicable):
- not specified
- Vehicle:
- not specified
- Analytical verification of doses or concentrations:
- not specified
- Duration of treatment / exposure:
- Exposures were from day 6 through day 15 of gestation
- Frequency of treatment:
- Exposures were for 6 hours each day
- Duration of test:
- On day 20 of gestation the rats were killed
Doses / concentrationsopen allclose all
- Remarks:
- Doses / Concentrations:
100 ppm
Basis:
no data
- Remarks:
- Doses / Concentrations:
400 ppm
Basis:
no data
- No. of animals per sex per dose:
- 10
- Control animals:
- yes
Results and discussion
Results: maternal animals
Effect levels (maternal animals)
- Dose descriptor:
- NOAEL
- Effect level:
- ca. 401.5 ppm
- Based on:
- test mat.
- Basis for effect level:
- other: maternal toxicity
Results (fetuses)
- Details on embryotoxic / teratogenic effects:
- Embryotoxic / teratogenic effects:no data
Effect levels (fetuses)
- Dose descriptor:
- NOAEL
- Effect level:
- ca. 401.5 ppm
- Based on:
- test mat.
- Basis for effect level:
- other: teratogenicity
Fetal abnormalities
- Abnormalities:
- not specified
Overall developmental toxicity
- Developmental effects observed:
- not specified
Any other information on results incl. tables
After analysis of samples collected during the exposure the mean chamber concentrations of diesel fuel were found to be 0, 101.8 (± 2.4) and 401.5 (± 15.39) ppm. There were no deaths during the study and all animals were normal in appearance throughout. At necropsy two 400 ppm animals had dark mottled lungs and one 100 ppm animal had two pups with a common placenta. Neither of these observations are considered to be treatment- related. Body weights were not affected by exposure to the test material. Food consumption of treated and control animals was similar at the time periods examined except for the 400 ppm group which had a reduced food intake during the gestation period, days 7-15 only. No treatment-related changes were observed on observation of the uterine contents. There was no difference in sex ratios attributable to exposure to test material.
The actual numbers were:
Exposure | Males | Females |
0 ppm | 29 | 32 |
101.8 ppm | 35 | 37 |
401.5 ppm | 35 | 25 |
No treatment-related differences were found in any of the following parameters:
Nidation index (females with implantations/bred)
Females dying prior to cesarean section
Live litters Implantation sites (for each uterine horn)
Resorptions Litters with resorptions
Dead fetuses
Litters with dead fetuses
Live fetuses/implantation site
Mean live litter size
Average fetal weight
Examination of the offspring at delivery revealed no visible abnormalities except for subcutaneous hematomas which occurred as follows:
0 ppm group 1
101.8 ppm group 4
401.5 ppm group 4
There were no abnormalities found in the soft tissues of the fetuses after examination of the Bouin's fixed specimens. Some changes were observed during the skeletal examination of the stained fetuses. The "unusual changes" shown in the following table consisted of retarded bone ossification and were not malformations as such. It was noted in the report that such changes, although not normal, were frequently observed in 20 day old fetuses of the strain and source of rat used in the study. The report concluded that neither the frequency nor the character of the changes indicated an adverse effect on fetal growth and development or a teratogenic potential.
Exposure (ppm) | Fetuses examined | Fetuses normal | Fetuses with commonly found changes | Fetuses with unusual skeletal variations |
0 | 127 (16) | 70 (16) | 50 (14) | 7 (3) |
101.8 | 155 (19) | 68 (16) | 70 (18) | 17 (8) |
401.5 | 128 (16) | 66 (16) | 62 (15) | 0 (0) |
Figures in parenthesis indicate No. of litters
Applicant's summary and conclusion
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.