Registration Dossier
Registration Dossier
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EC number: 203-716-3 | CAS number: 109-89-7
Short-term toxicity to fish
Administrative data
- Endpoint:
- short-term toxicity to fish
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: OECD guideline study, published in literature, minor restrictions in reporting, but otherwise adequate for assessment
Data source
Reference
- Reference Type:
- publication
- Title:
- Aquatic toxicological aspects of dithiocarbamates and related compunds. I. Short-term toxicity tests.
- Author:
- van Leeuwen CJ, Maas-Diepeveen JL, Niebeek G, Vergouw WHA, Griffioen NPS and Luijken MW
- Year:
- 1 985
- Bibliographic source:
- Aquatic Toxicology, 7: 145-164
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 203 (Fish, Acute Toxicity Test)
- Deviations:
- yes
- Remarks:
- yes (slight modifications)
- GLP compliance:
- not specified
Test material
- Reference substance name:
- Diethylamine
- EC Number:
- 203-716-3
- EC Name:
- Diethylamine
- Cas Number:
- 109-89-7
- Molecular formula:
- C4H11N
- IUPAC Name:
- diethylamine
- Details on test material:
- - Name of test material (as cited in study report): Diethylamine
- Source: Fluka
- Purity: 99%
Constituent 1
Sampling and analysis
- Analytical monitoring:
- no
Test solutions
- Vehicle:
- no
Test organisms
- Test organisms (species):
- Poecilia reticulata
Study design
- Test type:
- semi-static
- Water media type:
- freshwater
- Limit test:
- no
- Total exposure duration:
- 96 h
Test conditions
- Nominal and measured concentrations:
- The stock solutions were prepared fresh each day. The test solutions were renewed daily. Detailed information about the chemical composition of the media is given elsewhere (Van Leeuwen and Maas, 1985). The tests with Na2S, CS2 and the amines were conducted in sealed vessels. LC50 values and their 95% confidence intervals were calculated according to the Litchfield and Wilcoxon (1949) method.
Results and discussion
Effect concentrations
- Duration:
- 96 h
- Dose descriptor:
- LC50
- Effect conc.:
- 130 mg/L
- Nominal / measured:
- nominal
- Conc. based on:
- test mat.
- Basis for effect:
- mortality (fish)
- Remarks on result:
- other: 95% confidence limit: 100 to 180 mg/l
Applicant's summary and conclusion
- Validity criteria fulfilled:
- yes
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