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EC number: 935-783-6 | CAS number: -
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Endpoint summary
Administrative data
Description of key information
Additional information
The relevant data on acute toxicity to aquatic organisms for Preventol KMX and the read across substance 4-chloro-3-methylphenol are summarized in the table below. The read across justification and additional data for m-cresol are attached to the Chemical Safety Report in Annex I. In comparison to the chlorocresols, m-cresol is only a minor component of Preventol KMX. Therefore these data are not considered for the assessment of the acute toxicity of Preventol KMX.
Table 1: Comparison of relevant data on acute toxicity of Preventol KMX and 4-chloro-3-methylphenol
Endpoint |
Preventol KMX |
4-chloro-3-methylphenol |
Short-term toxicity to fish |
OECD 203 |
Method: EPA OPP 72-1 |
Long-term toxicity to fish |
Read across 4-chloro-3-methylphenol |
Prolonged tests OECD204/215 |
Short-term toxicity to aquatic invertebrates |
OECD202 |
Method: EPA OPP 72-2 |
Long-term toxicity to aquatic invertebrates |
Read across 4-chloro-3-methylphenol |
OECD211 |
Toxicity to aquatic algae and cyanobacteria |
OECD 201 |
OECD201 NOErC (72 h): 3.2 mg/L (nominal) |
Toxicity to aquatic microorganisms |
OECD 209 EC10 (3h): 29.9 mg/L, |
ISO 8192 EC50 (30 min): 60.3 mg/L |
Acute toxicity of the reaction mass to aquatic organisms was studied for three trophic levels (fish, aquatic invertebrates and algae). For fish an LC50 (96h) of 6.7 mg/L is reported. Daphnia magna turned out to be the most sensitive species with a reported EC50 (48h) of 3.0 mg/L. Testing with green algae resulted in an ErC50 (72h) of 24 mg/L and in a NOEC of 3.2 mg/L.
No long-term toxicity studies on fish and aquatic invertebrates for the reaction mass are available. The substance is a mixture of four different m-cresols which are similar in physico-chemical properties, environmental fate and metabolism.
For one of the components of the reaction mass (4-chloro-m-cresol, CAS No. 59-50-7) aquatic long-term toxicity was investigated for fish and daphnia. These studies are used as read across for the reaction mass. Fish was shown to be more sensitive with a NOEC of 0.15 mg/L than Daphnia magna with a NOEC of 0.32 mg/L.
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