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EC number: 687-783-8 | CAS number: 13222-26-9
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Skin irritation / corrosion
Administrative data
- Endpoint:
- skin corrosion: in vitro / ex vivo
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- From April 27 to May 3, 2011
- Reliability:
- 1 (reliable without restriction)
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 2 011
- Report date:
- 2011
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 435 (In Vitro Membrane Barrier Test Method for Skin Corrosion)
- GLP compliance:
- yes
Test material
- Reference substance name:
- 2-chloro-2-methylpropanoyl chloride
- EC Number:
- 687-783-8
- Cas Number:
- 13222-26-9
- Molecular formula:
- C4H6Cl2O
- IUPAC Name:
- 2-chloro-2-methylpropanoyl chloride
- Details on test material:
- - Name of test material (as cited in study report): 2-chloroisobutytylchloride
- Physical state: liquid
- Analytical purity: 97.88%
- Lot/batch No.: 012001
- Expiration date of the lot/batch: June 2011
- Stability under test conditions: stable
- Storage condition of test material: room temperature, protected from light
Constituent 1
Test animals
- Details on test animals or test system and environmental conditions:
- The “In Vitro Membrane Barrier Test" use a bio-barrier membrane constructed to have physico-chemical properties similar to rat skin.
Test system
- Preparation of test site:
- other: bio-barrier
- Vehicle:
- unchanged (no vehicle)
- Controls:
- not required
- Amount / concentration applied:
- 500 μL of the test item were placed directly atop the BIOBARRIER.
The test was performed on a total of seven BIOBARRIERS (four BIOBARRIERS for the test item; one each for the positive and negative control and one as colour control). - Observation period:
- One BIOBARRIER disc was added on top of the first vial. 500 μL of the test item were applied evenly on the top of the BIOBARRIER disc and starting
time was recorded. This step was repeated for the remaining vials, staggering each start time by e.g. 10 seconds. The start time difference for each vial was subtracted from the final time to determine the net response time. As soon as a reaction had been observed, the time was recorded. - Number of animals:
- None (in vitro test).
Results and discussion
Any other information on results incl. tables
The mean time, required to activate the CDS was 26.25 ± 1.18 min.
CORROSITEX™ time [min] | colourchange | consistencychange | |
Replicate 1 | 25:15 | yes | no |
Replicate 2 | 25:05 | yes | no |
Replicate 3 | 26:40 | yes | no |
Replicate 4 | 28:00 | yes | no |
Mean ± SD | 26.25 ± 1.18 | ||
Positive control | 2:07 | yes | no |
Negative control | 128:00 | yes | no |
The test substance was compatible with the CORROSITEX™ Assay, as assessed in the qualification step. The categorization step and the classification step could be performed.
The test substance has been categorized to category 1.
A direct colour change was observed in tube A and the category was read from the CORROSITEX™ colour chart.
In this study under the given conditions the test substance showed corrosive effects. The test substance is classified as “CORROSIVE”, subcategory 1B according to the UN GHS, as the mean time to activate the CDS was > 3 – 60 min (26.25 ± 1.18 min., category 1). The test substance is therefore assigned to Packing Group 2 and to EU Risk-Phrase R 34.
The controls confirmed the validity of the study. The test substance qualified for the CORROSITEX™ Assay, as assessed in the qualification test. The positive control activated the CDS within three minutes (2:07 min.), the negative control did not activate the CDS before 60 min. (128 min.).
Applicant's summary and conclusion
- Interpretation of results:
- corrosive
- Remarks:
- Migrated information Criteria used for interpretation of results: EU
- Conclusions:
- In this study under the given conditions the test substance showed corrosive effects. The test substance is classified as “CORROSIVE”,
subcategory 1B according to the UN GHS, as the mean time to activate the CDS was > 3 – 60 min (category 1). The test substance is therefore
assigned to Packing Group 2 and to EU Risk-Phrase R 34. - Executive summary:
In the present study the skin corrosive potential of 2-chloroisobutyrylchloride was analysed. Corrosive chemicals are, dependent on their grade of corrosivity, able to break through the biobarrier membrane employed in the “In Vitro Membrane Barrier Test
(CORROSITEX™- Assay)” and subsequently activate the underlying CDS. Hence, the time necessary to activate the CDS allows to distinguish between corrosive (C) and non-corrosive (NC) test substances.
Additionally, it is possible to assess the dermal corrosion hazard potential including the subcategorisation of corrosive substances as permitted in the UN GHS (corrosive subcategory 1A, 1B, and 1C) and the assignment to EU Risk Phrases (R35, R34, no label).
Hereby, the test item was placed atop of the bio-barrier membrane. CDS activation was assessed as a colour change or a change in consistency. The time required to activate the CDS was matched with given thresholds.
In this study under the given conditions the test substance showed corrosive effects. The test substance is classified as “CORROSIVE”, subcategory 1B according to the UN GHS, as the mean time to activate the CDS was > 3 – 60 min (category 1). The test substance is therefore assigned to Packing Group 2 and to EU Risk-Phrase R 34.
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