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EC number: 685-281-3 | CAS number: 2624-17-1
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Endpoint summary
Administrative data
Description of key information
Read-across from in vivo studies of skin and eye irritation (where cyanuric acid was non-irritating). The same results can be extrapolated to sodium cyanurate.
Key value for chemical safety assessment
Skin irritation / corrosion
Link to relevant study records
- Endpoint:
- skin irritation / corrosion
- Remarks:
- other: read-across from an in vivo study with an analogue
- Type of information:
- migrated information: read-across from supporting substance (structural analogue or surrogate)
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: The analogue CAS nº 108-80-5 cyanuric acid shares the same functional group with the substance CAS nº 2624-17-1 sodium cyanurate and the results can be extrapolated to sodium cyanurate
- Reason / purpose for cross-reference:
- reference to other study
- Principles of method if other than guideline:
- Read-across approach from a study report (using the methods outlined by the OECD Guideline 404) on the analogue CAS nº 108-80-5 cyanuric acid
- GLP compliance:
- no
- Irritation parameter:
- primary dermal irritation index (PDII)
- Basis:
- mean
- Time point:
- other: 72 h
- Score:
- 0
- Interpretation of results:
- not irritating
- Remarks:
- Migrated information Criteria used for interpretation of results: EU
- Conclusions:
- Cyanuric acid is not irritating
The 72h-primary dermal irritation index (PDII) for substance sodium cyanurate is considered to be 0. - Executive summary:
- Based on the experimental results obtained with the analogue cyanuric acid (72h-primary dermal irritation index (PDII)= 0) the read-across approach is applied and the 72h-primary dermal irritation index (PDII) for substance sodium cyanurate is considered to be 0 under test conditions.
Reference
The analogue cyanuric acid shares the same functional group with the substance CAS nº 2624-17-1 sodium cyanurate and also has comparable values for the relevant molecular properties. These properties are:
- a low log Pow value which is -1.31 for cyanuric acid and 0.62 for sodium cyanurate,
- a high water solubility which is 2000 mg/L at 25 ºC for cyanuric acid and 22300 mg/L at 25 ºC for sodium cyanurate and
- similar molecular weights which are129.07 for cyanuric acid and 152.08 for sodium cyanurate.
As indicated in the European Chemical Agency Practical Guide 6 “How to report read –across and categories”, the structural grouping was realized using “OECD QSAR APPLICATION TOOL BOX” (see attachment).
Table 1: Data Matrix, Analogue Approach
CAS Number
|
108-80-5 |
2624-17-1 |
|
CHEMICAL NAME
|
Analogue 1 Cyanuric acid |
Sodium cyanurate |
|
PHYSICO-CHEMICAL DATA |
|||
Melting Point |
Experimental results: 320 - 440°C |
Estimated data: 305ºC |
|
Boiling Point |
No data |
Estimated data: 697.8ºC |
|
Density |
Experimental results: 1.75 g/ml |
Experimental results: 1.9 g/ml |
|
Vapour Pressure |
No data
|
Estimated data: 1.41E-016 mm Hg at 25ºC |
|
Partition Coefficient (log Kow) |
Experimental results: -1.31 at 25°C |
Estimated data: 0.62 |
|
Water solubility
|
Experimental results: 2000 mg/L at 25 ºC
|
Estimated data: 2.234E+004 mg/L at 25ºC |
|
ENVIRONMENTAL FATE and PATHWAY |
|||
Aerobic Biodegradation
|
Experimental results: Normally it degrades very slowly under aerobic conditions. Nevertheless, it can be readily degraded aerobically under nitrogen-limited conditions, but only by a limited number of microorganisms in certain conditions.
|
Read-across from Cyanuric acid: Normally it degrades very slowly under aerobic conditions. Nevertheless, it can be readily degraded aerobically under nitrogen-limited conditions, but only by a limited number of microorganisms in certain conditions.
|
|
Anaerobic Biodegradation |
Experimental results: Ready biodegradability |
Read-across from Cyanuric acid: Ready biodegradability
|
|
ENVIRONMENTAL TOXICITY |
|||
Acute Toxicity to Fish |
Experimental data: 96 h-LC50 > 1000 mg/L
|
Read-across from Cyanuric acid: 96 h-LC50 > 1178 mg/L
|
|
Acute Toxicity to Aquatic Invertebrates |
Experimental data: 48 h-LC50 > 1000 mg/L |
Read-across from Cyanuric acid: 48 h-LC50 > 1178 mg/L
|
|
Toxicity to Aquatic Plants
|
Experimental data: 96 h-EC50=712 mg/L (basis for effect: in vivo chlorophyll) 96 h-EC50=655 mg/L (basis for effect: cell number)
|
Experimental data: 72h-EC50 > 100 mg/L 72h-NOEC = 100 mg/L Experimental data: Sodium cyanurate monohydrate
72h-EbC50= 2700 mg/L (biomass) 72h- ErC50 > 5000 mg/L (growth rate) 72h- NOEC = 1250 mg/L (growth rate)
|
|
MAMMALIAN TOXICITY |
|||
Acute Oral |
Key study: LD50 > 5000 mg/kg bw |
Read-across from Cyanuric acid: LD50 > 5891 mg/kg bw
|
|
Acute Inhalation |
Key study: LC50 >5.25mg/L
|
Read-across from Cyanuric acid: LC50 >6.19mg/L
|
|
Acute Dermal |
Key study: LD50 > 5000 mg/kg bw |
Read-across from Cyanuric acid: LD50 > 5891 mg/kg bw
|
|
Repeated Dose |
Repeated dose toxicity: oral: Key study: 13 weeks in rats: NOAEL ca.231 mg/kg bw/day male NOAEL ca. 914 mg/kg bw/day female |
Repeated dose toxicity: oral: Key study: 28 days extended to 59 days in rats: LOAEL > 4000 ppm NOAEL = 4000 ppm Repeated dose toxicity oral: Key study: 104 weeks in mouse: NOAEL ca. 1520 mg/kg bw/day,male NOAEL ca. 1580 mg/kg bw/day, female Key study: Sodium cyanurate monohydrate:
Rat, 104 weeks
NOAEL ca. 154 mg/kg bw/day, male NOAEL ca. 266 mg/kg bw/day, female
|
|
Genetic Toxicity in vitro
|
Gene mutation in bacteria
|
No data |
Key study: Sodium cyanurate monohydrate: Negative |
Mammalian gene mutation
|
No data |
Key study: CHO, with and without metabolic activation, genotoxicity negative
|
|
Chromosomal aberration |
No data |
Key study: Mouse lymphoma L5178Y cells, with and without metabolic activation, genotoxicity negative
|
|
Genetic Toxicity in vivo
|
No data |
Key study: Rat bone marrow cytogenetics assay, genotoxicity negative
|
|
Carcinogenicity
|
No data |
Key study: Mouse, 104 weeks NOAEL ca. 1520 mg/kg bw/day, male NOAEL ca. 1580 mg/kg bw/day, female Key study: Sodium cyanurate monohydrate:
Rat, 104 weeks NOAEL ca. 154 mg/kg bw/day, male NOAEL ca. 266 mg/kg bw/day, female
|
|
Reproductive Toxicity |
No data
|
Key study: Rats, 100 and 120 days exposure- period of F0, F1 and F2 generations, both sexes. NOAEL: P male ca. 470 mg/kg bw/day P female ca. 950 mg/kg bw/day F1 male ca. 500 mg/kg bw/day F1 female ca. 910 mg/kg bw/day F2 male ca. 190 mg/kg bw/day F2 female ca. 970 mg/kg bw/day
Key study: Rabbit, developmental toxicity. NOAEL maternal = 50 mg/kg bw/day NOAEL teratogenicity = 500 mg/kg bw/day Key study: Sodium cyanurate monohydrate: Rat, developmental toxicity: NOAEL maternal = 5000 mg/kg bw/day NOAEL teratogenicity = 5000 mg/kg bw/day
|
Endpoint conclusion
- Endpoint conclusion:
- no adverse effect observed (not irritating)
Eye irritation
Link to relevant study records
- Endpoint:
- eye irritation
- Remarks:
- other: read-across from an in vivo study with an analogue
- Type of information:
- migrated information: read-across from supporting substance (structural analogue or surrogate)
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: The analogue CAS nº 108-80-5 cyanuric acid shares the same functional group with the substance CAS nº 2624-17-1 sodium cyanurate and the results can be extrapolated to sodium cyanurate.
- Reason / purpose for cross-reference:
- reference to other study
- Principles of method if other than guideline:
- Read-across approach from a study report (using the methods outlined by the OECD Guideline 405) on the analogue CAS nº 108-80-5 cyanuric acid.
- GLP compliance:
- no
- Irritation parameter:
- overall irritation score
- Basis:
- mean
- Time point:
- other: 72 h
- Score:
- 0.3
- Reversibility:
- fully reversible within: 3 days
- Interpretation of results:
- not irritating
- Remarks:
- Migrated information Criteria used for interpretation of results: EU
- Conclusions:
- Cyanuric acid is not irritating to eyes
The 72h-overall irritation score for substance sodium cyanurate is calculated to be 0.4. - Executive summary:
Based on the experimental results obtained with the analogue cyanuric acid (72h-overall irritation score= 0.3) the read-across approach is applied and the 72h-overall irritation score for substance sodium cyanurate is calculated to be 0.4 under test conditions.
Reference
The analogue cyanuric acid shares the same functional group with the substance CAS nº 2624-17-1 sodium cyanurate and also has comparable values for the relevant molecular properties. These properties are:
- a low log Pow value which is -1.31 for cyanuric acid and 0.62 for sodium cyanurate,
- a high water solubility which is 2000 mg/L at 25 ºC for cyanuric acid and 22300 mg/L at 25 ºC for sodium cyanurate and
- similar molecular weights which are129.07 for cyanuric acid and 152.08 for sodium cyanurate.
As indicated in the European Chemical Agency Practical Guide 6 “How to report read –across and categories”, the structural grouping was realized using “OECD QSAR APPLICATION TOOL BOX” (see attachment).
Table 1: Data Matrix, Analogue Approach
CAS Number
|
108-80-5 |
2624-17-1 |
|
CHEMICAL NAME
|
Analogue 1 Cyanuric acid |
Sodium cyanurate |
|
PHYSICO-CHEMICAL DATA |
|||
Melting Point |
Experimental results: 320 - 440°C |
Estimated data: 305ºC |
|
Boiling Point |
No data |
Estimated data: 697.8ºC |
|
Density |
Experimental results: 1.75 g/ml |
Experimental results: 1.9 g/ml |
|
Vapour Pressure |
No data
|
Estimated data: 1.41E-016 mm Hg at 25ºC |
|
Partition Coefficient (log Kow) |
Experimental results: -1.31 at 25°C |
Estimated data: 0.62 |
|
Water solubility
|
Experimental results: 2000 mg/L at 25 ºC
|
Estimated data: 2.234E+004 mg/L at 25ºC |
|
ENVIRONMENTAL FATE and PATHWAY |
|||
Aerobic Biodegradation
|
Experimental results: Normally it degrades very slowly under aerobic conditions. Nevertheless, it can be readily degraded aerobically under nitrogen-limited conditions, but only by a limited number of microorganisms in certain conditions.
|
Read-across from Cyanuric acid: Normally it degrades very slowly under aerobic conditions. Nevertheless, it can be readily degraded aerobically under nitrogen-limited conditions, but only by a limited number of microorganisms in certain conditions.
|
|
Anaerobic Biodegradation |
Experimental results: Ready biodegradability |
Read-across from Cyanuric acid: Ready biodegradability
|
|
ENVIRONMENTAL TOXICITY |
|||
Acute Toxicity to Fish |
Experimental data: 96 h-LC50 > 1000 mg/L
|
Read-across from Cyanuric acid: 96 h-LC50 > 1178 mg/L
|
|
Acute Toxicity to Aquatic Invertebrates |
Experimental data: 48 h-LC50 > 1000 mg/L |
Read-across from Cyanuric acid: 48 h-LC50 > 1178 mg/L
|
|
Toxicity to Aquatic Plants
|
Experimental data: 96 h-EC50=712 mg/L (basis for effect: in vivo chlorophyll) 96 h-EC50=655 mg/L (basis for effect: cell number)
|
Experimental data: 72h-EC50 > 100 mg/L 72h-NOEC = 100 mg/L Experimental data: Sodium cyanurate monohydrate
72h-EbC50= 2700 mg/L (biomass) 72h- ErC50 > 5000 mg/L (growth rate) 72h- NOEC = 1250 mg/L (growth rate)
|
|
MAMMALIAN TOXICITY |
|||
Acute Oral |
Key study: LD50 > 5000 mg/kg bw |
Read-across from Cyanuric acid: LD50 > 5891 mg/kg bw
|
|
Acute Inhalation |
Key study: LC50 >5.25mg/L
|
Read-across from Cyanuric acid: LC50 >6.19mg/L
|
|
Acute Dermal |
Key study: LD50 > 5000 mg/kg bw |
Read-across from Cyanuric acid: LD50 > 5891 mg/kg bw
|
|
Repeated Dose |
Repeated dose toxicity: oral: Key study: 13 weeks in rats: NOAEL ca.231 mg/kg bw/day male NOAEL ca. 914 mg/kg bw/day female |
Repeated dose toxicity: oral: Key study: 28 days extended to 59 days in rats: LOAEL > 4000 ppm NOAEL = 4000 ppm Repeated dose toxicity oral: Key study: 104 weeks in mouse: NOAEL ca. 1520 mg/kg bw/day,male NOAEL ca. 1580 mg/kg bw/day, female Key study: Sodium cyanurate monohydrate:
Rat, 104 weeks
NOAEL ca. 154 mg/kg bw/day, male NOAEL ca. 266 mg/kg bw/day, female
|
|
Genetic Toxicity in vitro
|
Gene mutation in bacteria
|
No data |
Key study: Sodium cyanurate monohydrate: Negative |
Mammalian gene mutation
|
No data |
Key study: CHO, with and without metabolic activation, genotoxicity negative
|
|
Chromosomal aberration |
No data |
Key study: Mouse lymphoma L5178Y cells, with and without metabolic activation, genotoxicity negative
|
|
Genetic Toxicity in vivo
|
No data |
Key study: Rat bone marrow cytogenetics assay, genotoxicity negative
|
|
Carcinogenicity
|
No data |
Key study: Mouse, 104 weeks NOAEL ca. 1520 mg/kg bw/day, male NOAEL ca. 1580 mg/kg bw/day, female Key study: Sodium cyanurate monohydrate:
Rat, 104 weeks NOAEL ca. 154 mg/kg bw/day, male NOAEL ca. 266 mg/kg bw/day, female
|
|
Reproductive Toxicity |
No data
|
Key study: Rats, 100 and 120 days exposure- period of F0, F1 and F2 generations, both sexes. NOAEL: P male ca. 470 mg/kg bw/day P female ca. 950 mg/kg bw/day F1 male ca. 500 mg/kg bw/day F1 female ca. 910 mg/kg bw/day F2 male ca. 190 mg/kg bw/day F2 female ca. 970 mg/kg bw/day
Key study: Rabbit, developmental toxicity. NOAEL maternal = 50 mg/kg bw/day NOAEL teratogenicity = 500 mg/kg bw/day Key study: Sodium cyanurate monohydrate: Rat, developmental toxicity: NOAEL maternal = 5000 mg/kg bw/day NOAEL teratogenicity = 5000 mg/kg bw/day
|
Endpoint conclusion
- Endpoint conclusion:
- no adverse effect observed (not irritating)
Respiratory irritation
Endpoint conclusion
- Endpoint conclusion:
- no study available
Additional information
Read-across:
Justification for selection of skin irritation / corrosion endpoint:
Read-across approach. Study not performed to GLP and no guideline stated but meets the basic requirements of a guideline study (Klimisch 2).
Justification for selection of eye irritation endpoint:
Read-across approach. Study not performed to GLP and no guideline stated but meets the basic requirements of a guideline study (Klimisch 2).
Justification for classification or non-classification
In the in vivo skin and eye irritation studies cyanuric acid was non-irritant and therefore requires no classification under DSD or CLP. The same results can be extrapolated to sodium cyanurate.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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