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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Administrative data

Description of key information

rat oral LD50 = 161 mg/kg (NTP 1987)
rat dermal LD50 > 1500 mg/kg bw (Ulsamer 1980)
rabbit dermal LD50 = 281 mg/kg (Am.Cyanamid 1975/CPSC 2001)
inhalation LC50 (test waived: corrosive + limited exposure)

Key value for chemical safety assessment

Acute toxicity: via oral route

Link to relevant study records
Reference
Endpoint:
acute toxicity: oral
Type of information:
experimental study
Adequacy of study:
key study
Reliability:
1 (reliable without restriction)
Rationale for reliability incl. deficiencies:
other: Published test report from National Toxicology Program (US). Evaluated data from a reliable secondary source (US-CPSC).
Principles of method if other than guideline:
see attached tables (results)
GLP compliance:
not specified
Remarks:
NTP study
Test type:
standard acute method
Limit test:
no
Species:
rat
Strain:
Fischer 344
Sex:
male/female
Details on test animals or test system and environmental conditions:
Animals were housed five per cage. Feed and water were avaliable ad libitum.
Route of administration:
oral: gavage
Vehicle:
water
Doses:
75, 150, 300, 600, 1200 (mg/kg bw)
No. of animals per sex per dose:
5
Control animals:
no
Statistics:
Spearman-Karber
Sex:
male
Dose descriptor:
LD50
Effect level:
185 mg/kg bw
Based on:
act. ingr.
95% CL:
141 - 242
Sex:
female
Dose descriptor:
LD50
Effect level:
161 mg/kg bw
Based on:
act. ingr.
95% CL:
115 - 224
Mortality:
All male and female rats that received 600 or 1200 mg/kg THPC and all males that received 300 mg/kg THPC were dead by day 2.
Clinical signs:
Surviving rats of each sex that received 150 mg/kg had reddish fluid around the nostrils by day 3 and labored breathing.
Body weight:
final weights were not recorded.
Gross pathology:
Necropsies were not performed.
Interpretation of results:
Category 3 based on GHS criteria
Remarks:
Migrated information: rat oral LD50 = 161 mg/kg
Conclusions:
rat oral LD50 = 161 mg/kg
Endpoint conclusion
Endpoint conclusion:
adverse effect observed
Dose descriptor:
LD50
Value:
161 mg/kg bw

Acute toxicity: via inhalation route

Link to relevant study records
Reference
Endpoint:
acute toxicity: inhalation
Data waiving:
exposure considerations
Justification for data waiving:
other:
Endpoint conclusion
Endpoint conclusion:
no study available

Acute toxicity: via dermal route

Link to relevant study records
Reference
Endpoint:
acute toxicity: dermal
Type of information:
experimental study
Adequacy of study:
weight of evidence
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
other: Published data from peer reviewed journal. Evaluated data from a reliable secondary source (US-CPSC).
Reason / purpose for cross-reference:
reference to same study
Principles of method if other than guideline:
dermal LD50 study, 24 h exposure
GLP compliance:
not specified
Test type:
standard acute method
Limit test:
yes
Species:
rabbit
Strain:
not specified
Sex:
not specified
Details on test animals or test system and environmental conditions:
albino rabbits
Type of coverage:
not specified
Vehicle:
not specified
Duration of exposure:
24 hours
Doses:
4,084 mg/kg (body weight)
No. of animals per sex per dose:
no data
Control animals:
not specified
Details on study design:
no data
Statistics:
not applicable: no deaths occourred.
Sex:
not specified
Dose descriptor:
LD50
Effect level:
> 4 084 mg/kg bw
Based on:
test mat.
Mortality:
no deaths (at limit dose)
Clinical signs:
varying degrees of erythema and edema of the (integumentary system) treated skin.
Body weight:
no data
Gross pathology:
no data
Interpretation of results:
not classified
Remarks:
Migrated information Criteria used for interpretation of results: EU
Conclusions:
The acute dermal LD50 (rabbit) is greater then 4084 mg/kg bw.
Executive summary:

acute dermal LD50 (rabbit) > 4084 mg/kg bw.

Endpoint conclusion
Endpoint conclusion:
adverse effect observed
Dose descriptor:
LD50
Value:
281 mg/kg bw

Additional information

Justification for classification or non-classification

Acute Tox 3, H301 Toxic if swallowed

Acute Tox 3, H311 Toxic in contact with skin