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Diss Factsheets
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EC number: 205-592-6 | CAS number: 143-22-6
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Endpoint summary
Administrative data
Link to relevant study record(s)
Description of key information
Short description of key information on bioaccumulation potential result:
No bioaccumulation potential based on study results from supporting substance (structural analogue or surrogate) as 2-butoxyethanol.
Short description of key information on absorption rate:
An in vitro study determined that the permeability of 2-(2-(2-butoxyethoxy)ethoxy)ethanol to human skin is quite low. The permeability co-efficient was determined to be 22 +/-8.6ug/cm2/hr, which is around 1% of the skin penetration rate of the shorter chain glycol ether ethylene glycol methyl ether. Exposure to the substance also caused no significant deterioration of skin barrier properties.
Key value for chemical safety assessment
- Bioaccumulation potential:
- no bioaccumulation potential
- Absorption rate - dermal (%):
- 1
Additional information
Absorption, Distribution & Excretion:
Skin Absorption
Human abdominal whole skin (2.54 cm sq)
was mounted in a glass diffusion apparatus (at 30 +/- 1 degree C) and
the diffusion of triethylene glycol monobutyl ether was
monitored during a 12-hr period using gas chromatography (n=6). The
integrity of the epidermal membranes was first assessed by measuring
permeability of membranes to tritiated water. Epidermal membranes
displaying permeability constants greater than 1.5 x 10E-3 cm/hr were
deemed to have been damaged during preparation and were rejected. The
mean steady state of absorption for triethylene glycol monobutyl
ether was 22.2 ug/cm sq/hr (SD +/- 8.59), which was 100-fold
less than that of ethylene glycol monomethyl ether. Test material did
not increase permeability of the membrane (damage ratio of 1.26).
Metabolism
No metabolism data were located for the category members but the read-across data from supporting substance (structural analogue or surrogate) as 2-butoxyethanol indicate no bioaccumulation potential based on study results.
Discussion on absorption rate:
An in vitro study determined that the permeability of 2-(2-(2-butoxyethoxy)ethoxy)ethanol to human skin is quite low. The permeability co-efficient was determined to be 22 +/-8.6ug/cm2/hr, which is around 1% of the skin penetration rate of the shorter chain glycol ether ethylene glycol methyl ether. Exposure to the substance also caused no significant deterioration of skin barrier properties.
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