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Diss Factsheets
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EC number: 700-792-4 | CAS number: -
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Acute Toxicity: dermal
Administrative data
- Endpoint:
- acute toxicity: dermal
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 10 May - 30 May 2012
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- other: Experimental study conducted in GLP compliant lab according to EC and OECD test methods
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 2 012
- Report date:
- 2012
Materials and methods
Test guidelineopen allclose all
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 402 (Acute Dermal Toxicity)
- Deviations:
- no
- Qualifier:
- according to guideline
- Guideline:
- EU Method B.3 (Acute Toxicity (Dermal))
- Deviations:
- no
- Qualifier:
- according to guideline
- Guideline:
- EPA OPPTS 870.1200 (Acute Dermal Toxicity)
- Deviations:
- no
- GLP compliance:
- yes (incl. QA statement)
- Test type:
- standard acute method
Test material
- Reference substance name:
- Reaction mass of 1,2,2,6,6-pentamethylpiperidin-4-yl hexadecanoate and 1,2,2,6,6-pentamethylpiperidin-4-yl octadecanoate
- EC Number:
- 700-792-4
- Molecular formula:
- C26H51NO2, C28H55NO2
- IUPAC Name:
- Reaction mass of 1,2,2,6,6-pentamethylpiperidin-4-yl hexadecanoate and 1,2,2,6,6-pentamethylpiperidin-4-yl octadecanoate
- Test material form:
- other: white to pale yellow solid
- Details on test material:
- - Name of test material (as cited in study report): T-1640L
- Physical state: white to pale yellow solid
- Analytical purity: 98.74%
- Purity test date: 20 May 2011
- Lot/batch No.: 10121
- Expiration date of the lot/batch: 12 April 2013
- Stability under test conditions: stable
- Storage condition of test material: refrigerated in the dark under dry conditions
Constituent 1
Test animals
- Species:
- rat
- Strain:
- Sprague-Dawley
- Sex:
- male/female
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
- Source: Accredited commercial supplier
- Age at study initiation: 8-12 weeks prior to dosing
- Weight at study initiation:384 - 407g (males) and 243 - 270g (females)
- Fasting period before study: N/a
- Housing: solid bottomed polycarbonate cages with a stainless steel mesh lid
- Diet (e.g. ad libitum): ad libitum, Rat and Mouse No. 1 Maintenance Diet
- Water (e.g. ad libitum): ad libitum, potable water from public supply
- Acclimation period: 6 days
ENVIRONMENTAL CONDITIONS
- Temperature (°C): 19-23C
- Humidity (%): 40-70%
- Air changes (per hr): The animal room was kept at positive pressure with respect to the outside by its own supply of filtered fresh air, which was passed to atmosphere and not re-circulated.
- Photoperiod (hrs dark / hrs light):12hrs light/ 12hrs dark
IN-LIFE DATES: From: To: 10 May - 30 May 2012
Administration / exposure
- Type of coverage:
- occlusive
- Vehicle:
- other: 1% w/v methyl cellulose
- Details on dermal exposure:
- TEST SITE
- Area of exposure:dorso-lumbar region
- % coverage: 10%
- Type of wrap if used:porous gauze, held in place with a non-irritating dressing and further covered with a waterproof dressing
REMOVAL OF TEST SUBSTANCE
- Washing (if done): washed with warm water (30-40C)
- Time after start of exposure: 24h
TEST MATERIAL
- Amount(s) applied (volume or weight with unit):4 mL/kg bwt
- Concentration (if solution):500 mg/mL
- Constant volume or concentration used: yes constant concentration
- For solids, paste formed: yes/no
VEHICLE
- Amount(s) applied (volume or weight with unit): 4 mL/kg bwt
- Concentration (if solution): 1% w/v aqueous methyl cellulose
- Lot/batch no. (if required):Formulation prepared on day of dosing
- Purity: N/a - Duration of exposure:
- 24h exposure period
- Doses:
- 2000 mg/kg bwt
- No. of animals per sex per dose:
- 5
- Control animals:
- no
- Details on study design:
- - Duration of observation period following administration: 14 days
- Frequency of observations and weighing: observed twice daily but more frequently on day of dosing, weighed on days 1, 8 and 15
- Necropsy of survivors performed: yes
- Other examinations performed: clinical signs, body weight,macropathology
Results and discussion
Effect levels
- Sex:
- male/female
- Dose descriptor:
- LD50
- Effect level:
- > 2 000 mg/kg bw
- Based on:
- test mat.
- Mortality:
- No deaths
- Clinical signs:
- Very slight to slight erythema with eschar/scab formation was seen in two females (C9,C10) after bandage removal on Day 2. These reactions had resolved by Day 10. No dermal reactions were seen in the remaining animals throughout the study.
- Body weight:
- Four females (C6,C7,C9,C10) showed a low bodyweight gain or a slight bodyweight loss on Day 8, however all males and females achieved satisfactory bodyweight gains on Day 15.
- Gross pathology:
- No abnormalities noted.
- Other findings:
- No systemic response to treatment in any animal
Applicant's summary and conclusion
- Interpretation of results:
- not classified
- Remarks:
- Migrated information Criteria used for interpretation of results: EU
- Conclusions:
- The acute median lethal dermal dose (LD50) to rats of T-1640L was demonstrated to be
greater than 2000 mg/kg bodyweight.
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