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EC number: 205-483-3 | CAS number: 141-43-5
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Skin sensitisation
Administrative data
- Endpoint:
- skin sensitisation: in vivo (non-LLNA)
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: reliable source, basic data on the study were given
Data source
Reference
- Reference Type:
- publication
- Title:
- Alkanolamines - Sensitizing capacity, cross reactivity and review patch test reactivity
- Author:
- Wahlberg Jan., Boman A.
- Year:
- 1 996
- Bibliographic source:
- Dermatosen in Berful und Umwelt. Occupation and environment V 44: pg 222-224
Materials and methods
Test guideline
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- other: Guinea Pig Maximisation Test
- GLP compliance:
- not specified
- Type of study:
- guinea pig maximisation test
Test material
- Reference substance name:
- 2-aminoethanol
- EC Number:
- 205-483-3
- EC Name:
- 2-aminoethanol
- Cas Number:
- 141-43-5
- Molecular formula:
- C2H7NO
- IUPAC Name:
- 2-aminoethanol
- Details on test material:
- - Name of test material (as cited in study report): monoethanolamine
- Analytical purity: 99.9 %
- Impurities (identity and concentrations): < 0.1% diethanolamine and tetraethanolamine
Constituent 1
In vivo test system
Test animals
- Species:
- guinea pig
- Strain:
- Dunkin-Hartley
- Sex:
- not specified
- Details on test animals and environmental conditions:
- TEST ANIMALS
- Source: Sahlins Försöksdjursfarm (Malmö, Sweden)
- Housing: plastic cages
Study design: in vivo (non-LLNA)
Inductionopen allclose all
- Route:
- intradermal and epicutaneous
- Vehicle:
- water
- Concentration / amount:
- Induction concentrations: 0.6 % (intradermal) and 10.3% (epicutaneous)
Challenge concentrations: 4.01, 2.05 and 0.41%
Challengeopen allclose all
- Route:
- epicutaneous, open
- Vehicle:
- water
- Concentration / amount:
- Induction concentrations: 0.6 % (intradermal) and 10.3% (epicutaneous)
Challenge concentrations: 4.01, 2.05 and 0.41%
- No. of animals per dose:
- 15 animals for the test substance
12 animals for control - Details on study design:
- The GPMT protocol with the same experimental design as in a previous study on TEA (Boman et al., 1993) was followed. Groups of 15 animals were induced with either MEA, DEA or TEA and then challenged after three weeks with the inducing amine and the two others. Prior to the topical induction, pretreatment with 10% sodium dodecyl sulphate was carried out. The concentrations used for induction and challenge were based on previous experience with TEA and the concentrations of MEA and DEA were equimolar to those of TEA. The challenge reactions were read blindly 48 and 72 h after application or the patches (Finn chambers). Two separate experiments were carried out with MEA. Control groups of twelve animals were given the same treatment (Freund's Complete Adjuvant, vehicle, occlusion, etc.) except for the inducing amine.
- Challenge controls:
- no data
- Positive control substance(s):
- no
Results and discussion
In vivo (non-LLNA)
Resultsopen allclose all
- Reading:
- 1st reading
- Hours after challenge:
- 48
- Group:
- test chemical
- Dose level:
- 4.1 %
- No. with + reactions:
- 2
- Total no. in group:
- 15
- Remarks on result:
- other: Reading: 1st reading. . Hours after challenge: 48.0. Group: test group. Dose level: 4.1 %. No with. + reactions: 2.0. Total no. in groups: 15.0.
- Reading:
- 1st reading
- Hours after challenge:
- 48
- Group:
- test chemical
- Dose level:
- 2.05%
- No. with + reactions:
- 1
- Total no. in group:
- 15
- Remarks on result:
- other: Reading: 1st reading. . Hours after challenge: 48.0. Group: test group. Dose level: 2.05%. No with. + reactions: 1.0. Total no. in groups: 15.0.
- Reading:
- 1st reading
- Hours after challenge:
- 48
- Group:
- test chemical
- Dose level:
- 0.41%
- No. with + reactions:
- 2
- Total no. in group:
- 15
- Remarks on result:
- other: Reading: 1st reading. . Hours after challenge: 48.0. Group: test group. Dose level: 0.41%. No with. + reactions: 2.0. Total no. in groups: 15.0.
- Reading:
- 2nd reading
- Hours after challenge:
- 72
- Group:
- test chemical
- Dose level:
- 4.1%
- No. with + reactions:
- 3
- Total no. in group:
- 15
- Remarks on result:
- other: Reading: 2nd reading. . Hours after challenge: 72.0. Group: test group. Dose level: 4.1%. No with. + reactions: 3.0. Total no. in groups: 15.0.
- Reading:
- 2nd reading
- Hours after challenge:
- 72
- Group:
- test chemical
- Dose level:
- 2.05 %
- No. with + reactions:
- 2
- Total no. in group:
- 15
- Remarks on result:
- other: Reading: 2nd reading. . Hours after challenge: 72.0. Group: test group. Dose level: 2.05 %. No with. + reactions: 2.0. Total no. in groups: 15.0.
- Reading:
- 2nd reading
- Hours after challenge:
- 72
- Group:
- test chemical
- Dose level:
- 0.41
- No. with + reactions:
- 3
- Total no. in group:
- 15
- Remarks on result:
- other: Reading: 2nd reading. . Hours after challenge: 72.0. Group: test group. Dose level: 0.41. No with. + reactions: 3.0. Total no. in groups: 15.0.
- Reading:
- 1st reading
- Hours after challenge:
- 48
- Group:
- negative control
- Dose level:
- 4.1%
- No. with + reactions:
- 0
- Total no. in group:
- 12
- Remarks on result:
- other: Reading: 1st reading. . Hours after challenge: 48.0. Group: negative control. Dose level: 4.1%. No with. + reactions: 0.0. Total no. in groups: 12.0.
- Reading:
- 1st reading
- Hours after challenge:
- 48
- Group:
- negative control
- Dose level:
- 2.05
- No. with + reactions:
- 0
- Total no. in group:
- 12
- Remarks on result:
- other: Reading: 1st reading. . Hours after challenge: 48.0. Group: negative control. Dose level: 2.05. No with. + reactions: 0.0. Total no. in groups: 12.0.
- Reading:
- 1st reading
- Hours after challenge:
- 48
- Group:
- negative control
- Dose level:
- 0.41
- No. with + reactions:
- 0
- Total no. in group:
- 12
- Remarks on result:
- other: Reading: 1st reading. . Hours after challenge: 48.0. Group: negative control. Dose level: 0.41. No with. + reactions: 0.0. Total no. in groups: 12.0.
- Reading:
- 2nd reading
- Hours after challenge:
- 72
- Group:
- negative control
- Dose level:
- 4.1%
- No. with + reactions:
- 0
- Total no. in group:
- 12
- Remarks on result:
- other: Reading: 2nd reading. . Hours after challenge: 72.0. Group: negative control. Dose level: 4.1%. No with. + reactions: 0.0. Total no. in groups: 12.0.
- Reading:
- 2nd reading
- Hours after challenge:
- 72
- Group:
- negative control
- Dose level:
- 2.05%
- No. with + reactions:
- 0
- Total no. in group:
- 12
- Remarks on result:
- other: Reading: 2nd reading. . Hours after challenge: 72.0. Group: negative control. Dose level: 2.05%. No with. + reactions: 0.0. Total no. in groups: 12.0.
- Reading:
- 2nd reading
- Hours after challenge:
- 72
- Group:
- negative control
- Dose level:
- 0.41%
- No. with + reactions:
- 0
- Total no. in group:
- 12
- Remarks on result:
- other: Reading: 2nd reading. . Hours after challenge: 72.0. Group: negative control. Dose level: 0.41%. No with. + reactions: 0.0. Total no. in groups: 12.0.
Applicant's summary and conclusion
- Interpretation of results:
- not sensitising
- Remarks:
- Migrated information Criteria used for interpretation of results: EU
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