Registration Dossier
Registration Dossier
Data platform availability banner - registered substances factsheets
Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.
The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
Diss Factsheets
Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 220-635-9 | CAS number: 2840-28-0
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Carcinogenicity
Administrative data
- Endpoint:
- carcinogenicity: dermal
- Type of information:
- migrated information: read-across from supporting substance (structural analogue or surrogate)
- Adequacy of study:
- supporting study
- Reliability:
- 3 (not reliable)
- Rationale for reliability incl. deficiencies:
- other: read across, no information on test material and purity, very briefly documented
Data source
Reference
- Reference Type:
- publication
- Title:
- Lack of Toxicity and Carcinogenicity of Some Commonly Used Cutaneous Agents
- Author:
- Stenbaeck et al
- Year:
- 1 974
- Bibliographic source:
- TOXICOLOGY AND APPLIED PHARMACCLOGY 30, 7-13 (1974)
Materials and methods
Test guideline
- Qualifier:
- no guideline followed
- GLP compliance:
- no
Test material
- Reference substance name:
- p-aminobenzoic acid
- IUPAC Name:
- p-aminobenzoic acid
- Reference substance name:
- 4-aminobenzoic acid
- EC Number:
- 205-753-0
- EC Name:
- 4-aminobenzoic acid
- Cas Number:
- 150-13-0
- IUPAC Name:
- 4-aminobenzoic acid
Constituent 1
Constituent 2
Test animals
- Species:
- mouse
- Strain:
- Swiss Webster
- Sex:
- female
- Details on test animals or test system and environmental conditions:
- age: 7 weeks
randomized
housed in plastic cages with commercial bedding, 10 per cage
commercial diet, ad libitum
water ad libitum
Administration / exposure
- Route of administration:
- dermal
- Vehicle:
- acetone
- Details on exposure:
- TEST SITE
- Area of exposure: dorsal skin
- 1 inch-square
TEST MATERIAL
- Amount(s) applied (volume or weight with unit): 0.02 ml
- Concentration (if solution): 1, 5 and 10 %
- Constant volume or concentration used: yes - Analytical verification of doses or concentrations:
- no
- Duration of treatment / exposure:
- live span
- Frequency of treatment:
- twice a week
Doses / concentrations
- Remarks:
- Doses / Concentrations:
1, 5, 10%
Basis:
- No. of animals per sex per dose:
- 50/mouse/dose
- Control animals:
- yes, concurrent no treatment
- yes, concurrent vehicle
Examinations
- Sacrifice and pathology:
- Complete autopsies were performed on all animals. The skin from all animals, all grossly observed tumors and other lesions in the lungs, livers, kidneys, etc., from treated as well as control groups were studied histologically. Formalin-fixed paraffin-embedded specimens were cut and stained with hematoxylin-eosin and other stains when needed.
- Statistics:
- The statistical significance of the results was evaluated using the methods presented by Armitage (1971).
Results and discussion
Results of examinations
- Gross pathological findings:
- no effects observed
- Histopathological findings: non-neoplastic:
- no effects observed
- Histopathological findings: neoplastic:
- no effects observed
Effect levels
- Dose descriptor:
- NOAEL
- Sex:
- female
- Basis for effect level:
- other: None of the chemicals studied produced a statistically significant increase in skin tumor incidence.
- Remarks on result:
- not determinable
- Remarks:
- no NOAEL identified. Effect type:carcinogenicity (migrated information)
Applicant's summary and conclusion
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.