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EC number: 406-200-8 | CAS number: 117827-06-2 COUPLER II; UC-136
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Short-term toxicity to aquatic invertebrates
Administrative data
- Endpoint:
- short-term toxicity to aquatic invertebrates
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- From 1989, october 30th to 1989, november
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- other: GLP study performed according to the Test Guidelines described in the EEC Directive 84/449/EEC
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 989
- Report date:
- 1990
Materials and methods
Test guidelineopen allclose all
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 202 (Daphnia sp. Acute Immobilisation Test)
- Qualifier:
- according to guideline
- Guideline:
- EU Method C.2 (Acute Toxicity for Daphnia)
- GLP compliance:
- yes
Test material
- Reference substance name:
- 3',5'-dichloro-4'-ethyl-2'-hydroxypalmitanilide
- EC Number:
- 406-200-8
- EC Name:
- 3',5'-dichloro-4'-ethyl-2'-hydroxypalmitanilide
- Cas Number:
- 117827-06-2
- Molecular formula:
- C24H39Cl2NO2
- IUPAC Name:
- N-(3,5-dichloro-4-ethyl-2-hydroxyphenyl)hexadecanamide
- Details on test material:
- UC-136
RCC notox substance: 1763
RCC Notox old project: 1343
White powder
Purity 98.5%
Storage conditions: at room temperature in the dark in a tighly sealed container
Stability of test substance: stable for one year maximal under storage conditions
Expiry date: january 5 1990
Stability in vehicles : unknown
Safety precautions: gloves and goggles were used to assure personnel health and safety
Constituent 1
Test organisms
- Test organisms (species):
- Daphnia magna
- Details on test organisms:
- Species : Daphnia magna (Crustacea, Cladocera) ( Straus, 1820)
Breeding: Synchronously in DSW with a density of 25 daphnia per litre in a climate room.
Start of’ each batch With newborn animals, i.e. less than 3 days old, by placing about 250 of them into 10 litres of DSW in an all—glass culture vessel.
Maximum age of the cultures 4 weeks
Renewal of’ the cultures After 7 days of cultivation half of the volume medium twice a week.
Reason for selection This system has been selected as an internationally accepted species and recommended by the referred guidelines.
Medium Dutch standard water (DSW): formulated using Milli—Q water according to Adema (Adema D.M.M., 1980; in: Degradability, Eco—toxicity
and Bioaccumulation: The determination of the possible effects of chemicals and wastes on the aquatic environment, Chapter 5, Government Publishing Office, The Hague, The Netherlands).
Milli—Q water: tap water purified by reverse osmosis and subsequently passed over activated carbon and ion—exchange cartridges (Millipore Corp., Bedford, Mass., USA).
Temperature 20± 2°C
Feed A suspension of fresh water algae.
Frequency Once a day
Characteristics For the test selection of young daphnia with an age of <24 hours.
Validity of batch Frequent inspection of the cultures with respect to number of young, appearance of young and parental daphnia and global feedingbehaviour.
Control of sensitivity In a 24—hour reference test with potassium di chromate.
Study design
- Test type:
- static
- Water media type:
- freshwater
- Limit test:
- yes
- Total exposure duration:
- 24 h
Test conditions
- Hardness:
- 11.7°DH
- Test temperature:
- 19.0 to 20.0°C
- pH:
- 7.8 to 8.3
- Dissolved oxygen:
- > 5 mg/L
- Salinity:
- Ca2+ 54.5 mg/L
Mg2+ 17.8 mg/L
Na+ 27.4 mg/L
K+ 7.8 mg/L
Cl- 96.3 mg/L
a) CO3 2- ---
b) HCO3- 84.8 mg/L
SO4 2- 70.2 mg/L - Nominal and measured concentrations:
- an oversaturated solution of 1000mg/L infiltrated and filtrated (=saturated solution)
- Details on test conditions:
- Identification The vessels were individually identified by means of’ adhesive labels as described in detail in RCC NOTOX’s Standard Operating Procedures.
Method As described in the guideline with some mociifications, in accordance with the standard operation procedure: SOP ET/1641.
Test type Limit test, static Test duration 24 hours Test vessels 250 ml, all—glass
Test medium Dutch standard water.
Number of daphnia 20 per concentration
Loading 10 per vessel
Light 16 hours photoperiod daily
Room temperature 20.0°C
Feeding No feeding
Concentration range Because the test substance was hardly soluble in water a limit study was performed, i.e. exposure to an oversaturated solution of 1000 mg/l unfiltrated and filtrated (=saturated solution).
Controls Blank: test medium without test substance or other additives.
Treatment stock solutions The test substance was hardly soluble in water.
Preparation of the stock solution: 958.4 mg of test substance was quantitatively added to 1000 ml medium providing a stock solution of 1000 mg/l. This oversaturated stock solution was stirred for 48 hours.
Subsequently, from this solution 200 ml was taken and filtrated over a 45 um filter and as such tested, Le. 2x100 ml divided over 2 vessels.
From the stirred solution another 2x100 ml were taken and tested without filtration.
In these solutions precipitation of test substance was present.
Introduction of young daphnia The daphnia were introduced into the test medium within approximately 30 minutes after preparation of the test media. - Reference substance (positive control):
- yes
- Remarks:
- The reference substance potassium dichromate was tested at the same time as the final test with UC—136, using daphnia from the same culture (Table 4). The 24—hour EC5O was 1.04 mg/l, which is within the expected range: 0.56—1.91 mg/l (n=20).
Results and discussion
Effect concentrations
- Duration:
- 24 h
- Dose descriptor:
- EC50
- Effect conc.:
- > 1 000 mg/L
- Nominal / measured:
- nominal
Applicant's summary and conclusion
- Validity criteria fulfilled:
- yes
- Conclusions:
- Under the conditions of the present study the test substance UC-136 appears to induce no immobility when Daphnia magna are exposed to either a saturated or an oversaturated solution.
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