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EC number: 700-408-5 | CAS number: 103429-90-9
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Acute Toxicity: oral
Administrative data
- Endpoint:
- acute toxicity: oral
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 1983-07-07 to 1983-07-27
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: No GLP compliance claim, no International Test Guidelines quoted (but all parameters are closely comparable to a guideline method) and the purity of the test substance is not reported.
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 983
- Report date:
- 1983
Materials and methods
Test guideline
- Qualifier:
- no guideline followed
- Principles of method if other than guideline:
- A preliminary study was conducted using single oral doses of 1.0 and 5.0 g/kg in two male and two female rats at each dose level. The preliminary rats were observed for clinical signs and mortality over a period of five days.
On the basis of the results of the preliminary study, the main study was conducted at dose levels 0 (control), 1.6, 2.5, 4.0, and 5.0 g/kg bodyweight. Five rats of each sex were used at each dose level. Following a single oral dose, the rats were observed for clinical signs and mortality over a period of fourteen days. Bodyweights were recorded on days 1, 8, and 15. All surviving animals were sacrificed at day 15, and a macroscopic post mortem examination was conducted on all rats at death. - GLP compliance:
- no
- Test type:
- standard acute method
- Limit test:
- no
Test material
- Reference substance name:
- 3-Methoxy-3-methylbutyl acetate
- EC Number:
- 700-408-5
- Cas Number:
- 103429-90-9
- Molecular formula:
- C8H16O3
- IUPAC Name:
- 3-Methoxy-3-methylbutyl acetate
- Details on test material:
- - Name of test material (as cited in study report): 3-Methyl-3-methoxybutyl acetate
- Physical state: transparent, colourless liquid
- Storage condition of test material: Ambient temperature
Constituent 1
Test animals
- Species:
- rat
- Strain:
- Sprague-Dawley
- Sex:
- male/female
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
- Source: Hacking and Churchill Limited, Huntingdon, Cambridgeshire, England
- Age at study initiation: 4 - 6 weeks
- Weight at study initiation: 90 - 131 g
- Fasting period before study: Overnight
- Housing: Metal cages with wire mesh floors
- Diet: ad libitum
- Water: ad libitum
- Acclimation period: Minimun period of 5 days
ENVIRONMENTAL CONDITIONS
- Temperature (°C): 25-29
- Mean Relative Humidity (%): 57
- Air changes (per hr): approx 15
- Photoperiod (hrs dark / hrs light): 12/12
Administration / exposure
- Route of administration:
- oral: gavage
- Vehicle:
- unchanged (no vehicle)
- Details on oral exposure:
- VEHICLE
- Concentration in vehicle: Not applicable - test material was dosed as supplied.
MAXIMUM DOSE VOLUME APPLIED: 5.2 mL/Kg (specific gravity = 0.96 g/mL) - Doses:
- 0 (control=distilled water), 1.6, 2.5, 4.0, and 5.0 g/kg in main study
1.0 and 5.0 g/kg in preliminary study - No. of animals per sex per dose:
- 5/sex/group in the main study
2/sex/group in preliminary study - Control animals:
- yes
- Details on study design:
- - Duration of observation period following administration: 14 days (5 days for preliminary study)
- Frequency of observations and weighing: observations were taken regularly on day 1, and at least twice daily on subsequent days. Bodyweights were recorded on days 1, 8, and 15, and at death.
- Necropsy of survivors performed: yes
- Other examinations performed: clinical signs, body weight - Statistics:
- The acute median lethal oral dose (LD50) to male and female rats was calculated using the method of:
Finney (1971) Probit Analysis (3rd Edition) Cambridge University Press.
Results and discussion
- Preliminary study:
- The results of the preliminary study indicated that the acute median lethal oral dose (LD50) to rats of 3-methyl-3-methoxybutyl acetate was between 1.0 and 5.0 g/kg bodyweight.
Effect levelsopen allclose all
- Sex:
- male/female
- Dose descriptor:
- LD50
- Effect level:
- 4 600 mg/kg bw
- Based on:
- test mat.
- 95% CL:
- 4 200 - 5 000
- Sex:
- male
- Dose descriptor:
- LD50
- Effect level:
- 4 700 mg/kg bw
- Based on:
- test mat.
- 95% CL:
- 4 100 - 5 400
- Sex:
- female
- Dose descriptor:
- LD50
- Effect level:
- 4 500 mg/kg bw
- Based on:
- test mat.
- 95% CL:
- 3 900 - 5 100
- Mortality:
- Mortailties occurred amongst rats treated at 4.0 and 5.0 g/kg bodyweight within 22 to 71 hours of dosing.
3 males and 3 females dosed at 5.0 g/kg were found dead at the first observation of day 2; a further male from this group was found dead at the first observation on day 3 and a further female at the second observation of day 3. One female rat dosed at 4.0 g/kg was found dead at the first observation of day 4. - Clinical signs:
- Abnormal body carriage (hunched posture), lethargy, decreased respiratory rate, increased salivation and ataxia was observed amongst treated rats.
Ptosis was seen in all rats treated at 2.5 g/kg and above.
Comatose-like condition was seen amongst rats treated at 4.0 and 5.0 g/kg.
Increased lacrimation was seen in four rats at 4.0 g/kg.
Pilo-erection only was observed in control animals. - Body weight:
- Poor weight gain was recorded in the occasional male rat at 2.5 g/kg and above and the occasional treated female rat on Day 8. Bodyweight gains were normal on Day 15.
- Gross pathology:
- Terminal autospy findings were normal.
Any other information on results incl. tables
Dose (g/kg) | Mortality ratio(No.ofdeaths)/(No.dosed) | Time of death after dosing |
||
Males | Females | Combined | ||
1.0 | 0/2 | 0/2 | 0/4 | - |
5.0 | 2/2 | 2/2 | 4/4 | <22 |
Applicant's summary and conclusion
- Interpretation of results:
- GHS criteria not met
- Conclusions:
- The acute median lethal oral dose and their 95% confidence limits to rats of MMB-Ac were estimated to be:
Males and females combined: 4.6 (4.2 to 5.0) g/kg bodyweight
Males Only: 4.7 (4.1 to 5.4) g/kg bodyweight
Females Only: 4.5 (3.9 to 5.1) g/kg bodyweight
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