Registration Dossier
Registration Dossier
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EC number: 691-963-1 | CAS number: 761441-54-7
Hydrolysis
Administrative data
Link to relevant study record(s)
Description of key information
A hydrolysis as a function of pH was conducted in accordance with the OECD 111 test guideline and GLP principles.
The hydrolysis of the test item was assessed in aqueous buffers pH 1.2 at 37°C (physiological conditions) and pH 4, 7 and 9 at 50 ± 0.5°C (Tier I).
Tier II tests were conducted at pH 4 and 9, for which a significant loss of test item had occurred, at 15, 37 and 50°C.
Throughout the study, the test item analysis showed inconsistent results (measures heterogeneity, measured test item concentrations higher than nominal concentrations, decreases followed by increases in concentrations, no degradation product identification).
Therefore, kinetics did not allow the estimation of a linear model with a sufficient quality as shown by the coefficients of determination. Consequently, the calculated half-lives below are not reliable:
¿ The half life of the test item at pH 4.0 and 25°C was determined to be 116.3 days
¿ The half life of the test item at pH 9.0 and 25°C was determined to be 971.7 days
The results indicate that hydrolysis takes place at a slow rate under environmental conditions. For the chemical safety assessment, a half-life of 1 year was selected as a conservative approach.
Key value for chemical safety assessment
- Half-life for hydrolysis:
- 1 yr
- at the temperature of:
- 25 °C
Additional information
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