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EC number: 939-526-9 | CAS number: 90506-73-3
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Acute Toxicity: dermal
Administrative data
- Endpoint:
- acute toxicity: dermal
- Type of information:
- migrated information: read-across from supporting substance (structural analogue or surrogate)
- Adequacy of study:
- weight of evidence
- Study period:
- 1989-07-10 to 1989-07-24
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: see 'Remark'
- Remarks:
- Read-across from GLP guideline study, tested with the source substance Aluminium dicetyl phosphate. In accordance to the ECHA guidance document “Practical guide 6: How to report read-across and categories (March 2010)”, the reliability was changed from RL1 to RL2 to reflect the fact that this study was conducted on a read-across substance.
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 989
- Report date:
- 1989
Materials and methods
Test guidelineopen allclose all
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 402 (Acute Dermal Toxicity)
- Deviations:
- no
- Qualifier:
- according to guideline
- Guideline:
- EU Method B.3 (Acute Toxicity (Dermal))
- Deviations:
- no
- GLP compliance:
- yes
- Test type:
- standard acute method
- Limit test:
- yes
Test material
- Reference substance name:
- Aluminium dicetyl phosphate
- IUPAC Name:
- Aluminium dicetyl phosphate
- Reference substance name:
- 26527-54-8 (Aluminium dicetyl phosphate)
- IUPAC Name:
- 26527-54-8 (Aluminium dicetyl phosphate)
- Reference substance name:
- Phosphoric acid, di-hexadecyl ester, aluminum salt
- IUPAC Name:
- Phosphoric acid, di-hexadecyl ester, aluminum salt
- Details on test material:
- - Physical state: solid
- Analytical purity: 100%
Constituent 1
Constituent 2
Constituent 3
Test animals
- Species:
- rat
- Strain:
- Crj: CD(SD)
- Sex:
- male/female
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
- Age at study initiation: 7 to 10 weeks
- Weight at study initiation: 205 to 250 g
- Fasting period before study: none
- Housing: individually in metal cages with wire mesh floors,
- Diet (e.g. ad libitum): standard laboratory rodent diet (Biosure LAD 1) ad libitum
- Water (e.g. ad libitum): domestic quality potable water ad libitum
- Acclimation period: 11 days
ENVIRONMENTAL CONDITIONS
- Temperature (°C): 20 – 26°C
- Humidity (%): 63% mean daily humidity
- Air changes (per hr): 15 air changes/hour
- Photoperiod (hrs dark / hrs light): 12/12
IN-LIFE DATES: From: 29-06-1989 To: 24-07-1989
Administration / exposure
- Type of coverage:
- occlusive
- Vehicle:
- water
- Details on dermal exposure:
- TEST SITE
- Area of exposure: dorsolumbar region
- % coverage: 10% of body surface, ca. 50 x 50 mm
- Type of wrap if used: treated area was covered with gauze, which was held in place by impermeable dressing encircled firmly around the trunk
REMOVAL OF TEST SUBSTANCE
- Washing (if done): warm water (30-40°C), blotted dry with absorbent paper
- Time after start of exposure: 24 h after start of exposure
TEST MATERIAL
- Amount(s) applied (volume or weight with unit): 2.0 g/kg bw
- For solids, paste formed: yes; moistened with distilled water
VEHICLE
- Amount(s) applied (volume or weight with unit): no data
- Purity: no data - Duration of exposure:
- 24 h
- Doses:
- 2000 mg/kg bw
- No. of animals per sex per dose:
- 5
- Control animals:
- not required
- Details on study design:
- - Duration of observation period following administration: 14 days
- Frequency of observations and weighing: observations twice daily, weighing on day 1, 8, 15
- Necropsy of survivors performed: yes
- Other examinations performed: clinical signs (nature, severity, approximate time of
onset and duration of each toxic sign - daily examination), dermal irritation (daily examination), body weight (day 1, 8, 15)
Results and discussion
Effect levels
- Sex:
- male/female
- Dose descriptor:
- LD50
- Effect level:
- > 2 000 mg/kg bw
- Based on:
- act. ingr.
- Mortality:
- none observed
- Clinical signs:
- other: none observed
- Gross pathology:
- Terminal autopsy findings were normal.
- Other findings:
- Sites of application of the test substance showed no irritation reactions or other dermal changes.
Applicant's summary and conclusion
- Interpretation of results:
- not classified
- Remarks:
- Migrated information Criteria used for interpretation of results: other: CLP, EU GHS (Regulation (EC) No 1272/2008)
- Conclusions:
- The acute lethal dermal dose to rats of Aluminium dicetyl phosphate was found to be greater than 2000 mg/kg bodyweight.
- Executive summary:
In an acute dermal toxicity study according to OECD guideline 402 performed as limit test, groups of young adult Crl:CDR(SD) BR rats (5 male, 5 female) were dermally exposed to Aluminium dicetyl phosphate moistened with distilled water for 24 hours to 10% of body surface area at a dose of 2000 mg/kg bw. Animals then were observed for 14 days.
Dermal LD50 Males and Females > 2000 mg/kg bw
No mortality occurred in this limit test.
No clinical signs of toxicity were observed throughout the observation period.
The skin at the application site showed no changes.
No test substance related gross pathological changes were found in any animals.
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