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EC number: 203-219-1 | CAS number: 104-61-0
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Toxicity to aquatic algae and cyanobacteria
Administrative data
Link to relevant study record(s)
Description of key information
OECD 201, EU Method C3, GLP, key study, validity 2:
72h-ErC10 = 23.2 mg/L.
72h-ErC50 = 63.5 mg/L.
Key value for chemical safety assessment
- EC50 for freshwater algae:
- 63.5 mg/L
- EC10 or NOEC for freshwater algae:
- 23.2 mg/L
Additional information
One valid key study is available to assess the toxicity of γ-nonalactone to the growth of the unicellular green alga Pseudokirchneriella subcapitata.
This study was performed according to EU method C3 and OECD guideline 201 with GLP statement.Triplicate algal cultures, with an initial cell density of 1.3 x 10^4/mL were exposed to the test substance dissolved in algal nutrient medium at nominal concentrations of 0.954, 3.05, 9.77, 31.3 and 100 mg/L, for 72 hours.
At the start of the test, the measured levels of the test substance in samples of the test cultures ranged between 66 and 101% of their nominal values. At 0.954 to 9.77 mg/L, the measured concentrations decreased during the test, with measured values between 19 and 48% of nominal at 72 hours (between 29 and 48% of their starting values). At the higher concentrations of 31.3 and 100 mg/L, the measured levels were maintained between 64 and 93% during the 72h exposure period, with measured levels between 98 and 108% of their starting concentrations at study termination. The test substance at 0.954 and 100 mg/L, that had been incubated without algal cells, gave higher measured levels than samples incubated in the presence of algal cells. These results indicated that the presence of agal cells affected the stability of the test substance. The overall mean measured levels of the test substance were 0.524, 2.16, 7.62, 23.0 and 75.1 mg/L.
Cell numbers were counted daily to monitor growth. Abnormally low cell counts were observed at a measured concentration of 0.524 mg/L. Although the reason for the low counts was not identified, it was not considered to be treatment-related as cell counts at measured concentrations of 2.16 and 7.62 mg/L were comparable to that of the control and provided sufficient information to enable the calculation of a NOEC. Therefore, cell counts at 0.524 mg/L were not included in the statistical analysis of the study data. This had not impact on either the integrity or validity of the study.
All validity criteria were fulfilled.
After 72h of exposure to the test substance, the ErC10 and ErC50 were 23.2 mg/L and 63.5 mg/L, respectively. The NOEC for growth rate was 7.62 mg/L.
In conclusion, the 72h-ErC50 at 63.5 mg/L and the 72h-ErC10 at 23.2 mg/L were chosen for the chemical safety assessment.
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