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Diss Factsheets
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EC number: 200-872-4 | CAS number: 75-46-7
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Toxicity to reproduction: other studies
Administrative data
- Endpoint:
- toxicity to reproduction: other studies
- Type of information:
- experimental study
- Adequacy of study:
- supporting study
- Reliability:
- 2 (reliable with restrictions)
Cross-reference
- Reason / purpose for cross-reference:
- reference to same study
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 977
- Report date:
- 1977
Materials and methods
- Principles of method if other than guideline:
- A group of 20 male and 20 female rats were exposed 6 hours/day for 90 days to 0 or 10000 ppm FKW 23 (also known as HFC-23). The following parameters were assessed: feces, food and water consumption, body weight gain, haematology, clinical biochemistry, urinalysis, sight, hearing, and dentition. Macroscopic and histologic pathologic examinations were performed, including the reproductive organs.
- GLP compliance:
- no
- Type of method:
- in vivo
Test material
- Reference substance name:
- Trifluoromethane
- EC Number:
- 200-872-4
- EC Name:
- Trifluoromethane
- Cas Number:
- 75-46-7
- Molecular formula:
- CHF3
- IUPAC Name:
- trifluoromethane
- Details on test material:
- -Purity: not reported
Constituent 1
Test animals
- Species:
- rat
- Strain:
- Sprague-Dawley
- Sex:
- male/female
Administration / exposure
- Route of administration:
- inhalation
- Type of inhalation exposure (if applicable):
- whole body
- Vehicle:
- air
- Analytical verification of doses or concentrations:
- yes
- Duration of treatment / exposure:
- 90 days
- Frequency of treatment:
- 6 hours/day
Doses / concentrationsopen allclose all
- Remarks:
- Doses / Concentrations:
10000 ppm
Basis:
nominal conc.
- Remarks:
- Doses / Concentrations:
0 ppm
Basis:
nominal conc.
- No. of animals per sex per dose:
- 20 male and 20 female/concentration
- Control animals:
- yes, concurrent vehicle
Results and discussion
Effect levels
open allclose all
- Dose descriptor:
- LOAEL
- Effect level:
- > 10 000 ppm
- Sex:
- male/female
- Basis for effect level:
- other: No adverse findings were noted at the highest concentration tested.
- Dose descriptor:
- NOAEL
- Effect level:
- 10 000 ppm
- Sex:
- male/female
- Basis for effect level:
- other: No adverse findings were noted at the highest concentration tested.
Any other information on results incl. tables
Gonads: No pathological findings were noted on the macroscopic examination. Absolute weights were within the normal range.
Microscopic findings in the testicle included: bilateral diffuse atrophy of the canaliculi (one control animal) and bilateral localized atrophy of the canaliculi (15 control animals and 10 test animals) and dyszoospermia (one control animal).
No microscopic findings were noted in the ovaries.
Prostate/Uterus: No macroscopic findings were noted in the prostate and uterus. One control animals had a localized atrophy in the the prostate. No microscopic findings were noted in the uterus.
Spermatocyst/mamma: No macroscopic or microscopic findings were noted.
Applicant's summary and conclusion
- Conclusions:
- The NOAEL for effects on reproductive organs was 10000 ppm, which was the highest concentration tested.
- Executive summary:
In a 90-day inhalation study in the rat, no adverse effects were noted following exposure in the reproductive organ weights or pathology findings.
The objective of this study was to assess the potential subchronic toxicity of the test substance in rats. Two groups of young adult male and female Sprague Dawley rats (20/sex/group) were administered by 0 or 10000 ppm via inhalation, 6 hrs/day, for approximately 90 days. Body weights, food consumption, and detailed clinical observations were evaluated weekly until sacrifice. The animals were
examined daily after dosing for acute clinical signs of systemic toxicity. Hematology endpoints were evaluated at necropsy. Clinical biochemistry endpoints were evaluated before the first exposure, after 7 test days, as well as after 6 and 13 weeks of treatment. Urinalysis examinations were conducted after 13 weeks of treatment. At scheduled necropsy, the rats were sacrificed and given a gross and microscopic pathological examination. No adverse histopathological or weight changes were observed in reproductive organs at any dose level tested.
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