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Diss Factsheets
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EC number: 202-854-1 | CAS number: 100-46-9
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Direct observations: clinical cases, poisoning incidents and other
Administrative data
- Endpoint:
- direct observations: clinical cases, poisoning incidents and other
- Type of information:
- other: case report
- Adequacy of study:
- other information
- Reliability:
- 4 (not assignable)
- Rationale for reliability incl. deficiencies:
- other: No OECD guideline or GLP defined. Several substances tested.
Data source
Reference
- Reference Type:
- publication
- Title:
- Unnamed
- Year:
- 1 984
Materials and methods
- Study type:
- other: Patch test
- Endpoint addressed:
- skin sensitisation
- Principles of method if other than guideline:
- Method: other: testing in concentrations of 0.1 % and 1.0 % in ethanol (70 %), 10 control persons. During a period of one year, a48-year-old chemist was doing some experimental work to produce game-tocides for the prevention of cross pollination in the agricultural industry. he was working with some intermediate products including epichlorhydrin, benzylamine and benzyl-1-amino-3 chloro-2-hydroxy-propane. Shortly after contact with these materials, he developed a dermatitis of both hands and face. After stopping his work, the dermatitis subsided within a few days. he had an atopic constitution with a history of hay fever. Intracutaneous tests to some inhalants including house-dust, grass polen and animal dender were positive. reactions to patch tests with the ICDRG series, including epoxy resin, showed weak reaktion to formaldehyde. patch tests to epichlorhydrine 0.01% and 0.1% in acetone were negative. However, the reactions to benzylamine and benzyl-1-amino-3 chloro-2-hydroxypropane were positive. Both materials dissolved in ethanol 70% were tested in concentrations of 0.1% and 1%. 10 control persons showed negative reactions to these chemicals.Although benzylamine is known as a strong irritant, the reactions to benzylamine and benzyl-1-amino-3 chloro-2-hydroxypropane may be considered as allergic reactions. The positive reactions are probably a manifestion of cross-sensitivity.
- GLP compliance:
- not specified
Test material
- Reference substance name:
- Benzylamine
- EC Number:
- 202-854-1
- EC Name:
- Benzylamine
- Cas Number:
- 100-46-9
- Molecular formula:
- C7H9N
- IUPAC Name:
- 1-phenylmethanamine
- Details on test material:
- - Name of test material: Benzylamine
Constituent 1
Results and discussion
Any other information on results incl. tables
Case report: During a period of one year, a 48-year-old chemist was doing some experimental work to produce game-tocides for the prevention of cross pollination in the agricultural industry. he was working with some intermediate products including epichlorhydrin, benzylamine and benzyl-1-amino-3 chloro-2-hydroxy-propane. Shortly after contact with these materials, he developed a dermatitis of both hands and face. After stopping his work, the dermatitis subsided within a few days. he had an atopic constitution with a history of hay fever. Intracutaneous tests to some inhalants including house-dust, grass polen and animal dender were positive. reactions to patch tests with the ICDRG series, including epoxy resin, showed weak reaktion to formaldehyde. patch tests to epichlorhydrine 0.01% and 0.1% in acetone were negative. However, the reactions to benzylamine and benzyl-1-amino-3 chloro-2-hydroxypropane were positive. Both materials dissolved in ethanol 70% were tested in concentrations of 0.1% and 1%. 10 control persons showed negative reactions to these chemicals.Although benzylamine is known as a strong irritant, the reactions to benzylamine and benzyl-1-amino-3 chloro-2-hydroxypropane may be considered as allergic reactions. The positive reactions are probably a manifestion of cross-sensitivity.
Applicant's summary and conclusion
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.