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Diss Factsheets
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EC number: 224-207-2 | CAS number: 4246-51-9
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Acute Toxicity: inhalation
Administrative data
- Endpoint:
- acute toxicity: inhalation
- Type of information:
- experimental study
- Adequacy of study:
- disregarded due to major methodological deficiencies
- Reliability:
- 3 (not reliable)
- Rationale for reliability incl. deficiencies:
- significant methodological deficiencies
- Remarks:
- test concentration unknown and co-exposure via inhalation, oral and dermal route.
Data source
Reference
- Reference Type:
- publication
- Title:
- Range-Finding Toxicity Data: List VII
- Author:
- Smyth HF, Carpenter CP, Weil CS, Pozzani UC, Striegel JA, Nycum JS
- Year:
- 1 969
- Bibliographic source:
- Am. Ind. Hyg. Assoc. J. 30: 470-476
Materials and methods
- Principles of method if other than guideline:
- Groups of six male or female albino rats where wholy body exposed to a flowing stream of vapor-ladened air. The vapor-air mixture was generated by passing 2.5 litres/minute of dried air at room temperature through a fritted glass disc immersed to a depth of at least one inch in approx. 50 mL of the test substance contained in a gas-washing bottle. Inhalations were continued for time periods in a logarithmic series with a ratio of two extending from one-fourth to eight hours, until the inhalation period killing about half the number of rats within 14 days is defined.
- GLP compliance:
- no
- Test type:
- other: Inhalation Hazard Test
Test material
- Reference substance name:
- 3,3'-oxybis(ethyleneoxy)bis(propylamine)
- EC Number:
- 224-207-2
- EC Name:
- 3,3'-oxybis(ethyleneoxy)bis(propylamine)
- Cas Number:
- 4246-51-9
- Molecular formula:
- C10H24N2O3
- IUPAC Name:
- 3,3'-[oxybis(ethane-2,1-diyloxy)]dipropan-1-amine
Constituent 1
Test animals
- Species:
- rat
- Strain:
- not specified
- Sex:
- not specified
- Details on test animals or test system and environmental conditions:
- No data
Administration / exposure
- Route of administration:
- inhalation: vapour
- Vehicle:
- air
- Details on inhalation exposure:
- Groups of six male or female albino rats where whole body exposed to a flowing stream of vapor-ladened air. The vapor-air mixture was generated by passing 2.5 litres/minute of dried air at room temperature through a fritted glass disc immersed to a depth of at least one inch in approx. 50 mL of the test substance contained in a gas-washing bottle. Inhalations were continued for time periods in a logarithmic series with a ratio of two extending from one-fourth to eight hours, until the inhalation period killing about half the number of rats within 14 days is defined.
- Analytical verification of test atmosphere concentrations:
- no
- Duration of exposure:
- 4 h
- Concentrations:
- No vapor concentration given in the report. As the whole body was exposed oral and dermal uptake might have also occurred in addition to inhalation. Thus, no reliable vapor concntration can be derived.
- No. of animals per sex per dose:
- 6 males or females
- Control animals:
- no
- Details on study design:
- - Duration of observation period following administration: 14 days
Results and discussion
Effect levels
- Dose descriptor:
- LC0
- Effect level:
- other: unknown exposure concentration
- Based on:
- test mat.
- Exp. duration:
- 4 h
- Remarks on result:
- other: No mortality. Mortality after 8-hour exposure. Co-exposure via inhalation, oral and dermal route.
- Mortality:
- No mortality after 4 hours exposure in an atmosphere saturated with the test substance at room temperature. Mortality after 8 hours.
Applicant's summary and conclusion
- Interpretation of results:
- study cannot be used for classification
- Conclusions:
- A 4 hours exposure to a flowing stream of vapor-ladened air with the test substance resulted in no mortality, whereas after 8 h exposure mortality occurred.
- Executive summary:
In an acute inhalation toxicity study with whole body exposure (Smyth et al., 1969), six albino rats were exposed to a vapour atmosphere of the test substance for a series of time periods ranging from 15 minutes up to 8 hours and observed for 14 days. A 4 hours exposure to a flowing stream of vapor-ladened air with the test substance resulted in no mortality, whereas after 8 h exposure mortality occurred. This study is not valid and therefore disregarded because the vapor concentration is unknown and co-exposure via inhalation, oral and dermal route occurred.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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